MKSAP Cardiology Flashcards
What are the indications for repair of mitral regurgitation?
Severe MR in
- symptomatic patients w/ EF >30%
- asymptomatic patients with EF 30-60% and/or LVESD >40 mm
- new onset afib
- pulmonary artery sys pressure >50 mmHg
What are the indications for repair of aortic regurgitation?
Severe AR in
- asymptomatic pts w/ LV dilation (LV end-systolic dimension >50 mm) or EF <50%
- pts undergoing cardiac surgery w/ ascending aorta diameter >45 mm
- increase in pulmonary systolic pressure by 25 mmHg or to >60 mmHg during stress echo
- symptomatic patients
What anti-coagulant is preferred in pregnancy and mechanical valve prosthesis?
Warfarin 5 mg or less can be used in first trimester. If higher dose needed can use UFH or LMWH. During second and third trimesters warfarin is preferred.
What is the MOA of Ranolazine and when is it used? What drugs should be avoided? What should be monitored?
- Inhibits the late sodium current which decreases sodium dependent calcium currents -> reduced wall tension & myocardial O2 consumption
- Stable angina
- Avoid w/ strong CYP inhibitors like ketoconazole, clarithromycin, ritonavir. With moderate inhibitors like verapamil and diltiazem decrease dose by 50% (max dose 500 mg bid)
- QTc
What valve disorders are associated with Noonan syndrome? Turner syndrome? Down syndrome?
- Pulmonary stenosis w/ dysplastic valve; HOCM, VSD, ASD
- Bicuspid aortic valve, aortic coarctation, aortic aneurysm
- ASD, VSD
What complication of an ablation procedure can present 1-4 weeks later w/ TIA after food intake or sudden onset neurologic sx?
Atrioesophageal fistula
Can also present w/ fever, chest pain, seizures, hematemesis, and endocarditis
What is low flow, low-gradient aortic stenosis and what is the management?
AS w/ low stroke volume (reduced EF) and low aortic gradient (<30 mmHg), in setting of small aortic valve area
Need dobutamine echo to distinguish between pseudostenosis (which can occur in severe LV dysfunction) vs anatomically severe AS
What are cannon A waves associated with?
Complete heart block, pulmonary HTN, and VT
What murmurs increase with standing and valsava? These murmurs decrease with squatting and leg raise. What murmurs increase w/ handgrip?
HOCM and mitral valve prolapse; for HOCM, LV chamber size decreases so degree of obstruction increases
MR, VSD, and AR increase w/ handgrip b/c increased CO and peripheral resistance
Who should be screened for AAA? What is the surveillance frequency?
Adult males age 65-75 who have smoked 100 cigarettes in their lifetime
Aneurysms <4 cm monitor every 2-3 years
4.1-5.4 cm monitor every 6-12 months
What drugs are contraindicated in severe aortic stenosis? Name 3.
Calcium channel blockers, beta blockers, nitrates
What imparts the highest risk for MI? What is the goal reduction of cholesterol for primary prevention?
- Elevated cholesterol levels
2. 50% reduction in LDL in high risk patients, 30-50% reduction in moderate risk patients
What are the criteria for metabolic syndrome?
At least 3 of the following: central obesity (>35 inches in women, >40 inches in men), hyperglycemia (fasting BG >100), low HDL (<40 in men, <50 in women), high TGs (>150), elevated BP (>130/85)
What baseline EKG findings makes an exercise EKG not useful? Name 4. What baseline TTE findings makes a stress echo not useful?
- LVH, LBBB, paced rhythm, pre-excitation, >1 mm ST segment depression
- Baseline wall motion abnormalities
What are contraindications to doing a dobutamine echo stress test? Name 5.
Severe baseline HTN, unstable angina, severe tachyarrhythmias, HOCM, severe AS, and large aortic aneurysm
What are contraindications to vasodilator nuclear perfusion stress tests? (Adenosine, dipyridamole). Name 4.
Active bronchospastic airway disease (wheezing), theophylline use, sick sinus syndrome, hypotension, and high degree AV block
Need to hold caffeine 12-24 hours before test
Name 3 different types of stress tests that can be performed with dobutamine.
Echo, nuclear perfusion, and cardiac MRI
What type of stress test is preferred in LBBB?
Vasodilator-induced stress b/c of the potential for false-positive septal perfusion abnormalities w/ dobutamine
For what murmurs should a TTE be obtained?
Systolic murmur 3/6 or higher, late or holosystolic murmur, diastolic or continuous murmur, or murmur w/ accompanying symptoms
What are the ECG findings of STEMI?
ST elevation of 1 mm or more in 2 or more contiguous leads, except V2-V3 where it should be >1.5 mm in women or >2 mm in men
Posterior MI presents w/ 2 mm ST segment depression in V1-V4
What are contraindications to prasugrel use and when should the dose be modified? What is one known side effect of ticagrelor?
- History of stroke and those age >75 y.o.
- Dose adjusted for weight <60 kg
- Dyspnea
Which medication is indicated in all patients receiving thrombolytic therapy for STEMI?
Clopidogrel
What do the TIMI and GRACE scores predict? Using these scores when should urgent revasc vs. delayed revasc be performed?
- TIMI - 14 day death, recurrent MI, and urgent revascularization rates
GRACE - 6 month mortality and MI risk - High risk (TIMI 5-7 or GRACE 141-372) get revasc within 24 hours; intermediate risk (TIMI 3-4 or GRACE 109-140) get revasc within 25-72 hours; low risk (TIMI 0-2 or GRACE 1-108) can have stress testing
How long should patients with NSTEMI that are medically treated receive anticoagulation?
At least 48 hours, and it is generally continued until discharge
Name 2 prescription drugs that can cause coronary vasospasm?
5-FU, bromocriptine
What 2 post-MI complications present w/ abrupt pulmonary edema or hypotension and a loud holosystolic murmur and thrill? What is the management?
- VSD (less severe pulmonary edema, step up in oxygen in right ventricle compared to right atrium)
Papillary muscle rupture (typically seen in inferior wall MI) - IABP, nitroprusside (afterload reduction), diuretics, surgery
What are the max doses of carvedilol and bisoprolol in HF?
Carvedilol 50 mg bid if weight >85 kg, otherwise 25 mg bid
Bisoprolol 10 mg daily
What are the indications for ICD?
EF 35% or less with NYHA class II-III, or EF 30% or less with NYHA class I 40 days after MI, 90 days after CABG or PCI
What prophylaxis should some heart failure recipients take for the first 6 months?
CMV prophylaxis for those who received heart from CMV positive donor
What are the indications for surgery in infective endocarditis? Name 4.
Infection lasting >5-7 days while on appropriate abx; symptomatic HF; left sided involvement with Staph aureus, fungal infections, or highly resistant organisms; heart block, annular or aortic abscess, or destructive penetrating lesions; prosthetic valve infection; recurrent emboli; large vegetations (>10 mm) after 1 or more clinical or silent embolic events
What valve area and gradient are found in severe mitral stenosis? What is the next step in management if sx of mitral stenosis and echo findings do not correspond?
- Valve area <1.5 cm^2, gradient >5-10 mmHg
2. Obtain stress echo b/c valve gradient may become elevated only with exercise
In what CV conditions is pregnancy contraindicated? Name 5.
Aortic stenosis, coarctation of aorta, EF <40% + NYHA class III or IV symptoms, hx of peripartum CM, unrepaired cyanotic heart disease, severe pulmonary HTN, Marfan syndrome w/ unrepaired aorta
When is C-section preferred? Name 3 conditions.
Severe decompensated CV disease, markedly dilated aorta, or in women receiving warfarin therapy
What drug should be given to those w/ peripartum cardiomyopathy with EF <35% besides GDMT?
Anti-coagulation with heparin or warfarin during late pregnancy and for at least 8 weeks post-partum
What are the indications for aortic repair in pregnant women w/ Marfan syndrome?
Aortic diameter >4.5 cm, or <4.5 cm + rapid dilatation of the aorta of personal/family history of aortic dissection
What medication is used to reduce the risk for doxorubicin cardiotoxicity?
Dexrazoxane
Which tyrosine kinase inhibitor is most frequently associated with cardiotoxicity?
Sunitinib -> HTN and HFrEF
What are contraindications to nitrates? Name 3.
HOCM, severe AS, or PDE-5 inhibitor use
What are the indications for thoracic endovascular aortic repair?
Descending aortic aneurysm diameter >6 cm, ascending aortic aneurysm >5 cm, rapid growth (>0.5 cm/year), or end organ damage
What are some drugs that can lead to pericardial effusion? Name 5.
Minoxidil
Sulfa drugs, hydralazine, isoniazide, phenytoin, procainamide, methyldopa
What ABI is diagnostic of PAD? Resting ABI above what number indicates noncompressible, calcified arteries? What TBI is diagnostic of PAD? What decrease of postexercise ankle pressure or ABI is diagnostic of PAD?
- 0.90 or less
- > 1.40
- 0.70 or less, or great toe systolic pressure <40 mmHg
- Decrease of ankle pressure >30 mmHg, or >20% decrease in ABI post-exercise
What are the preferred medications for thoracic aortic aneurysms?
Beta blockers
Beta blockers + losartan in patients with Marfan syndrome
How often should U/S be repeated for TAA? What imaging is used to evaluate rapid expansion of TAA or aortic dimension >5.5 cm?
- Yearly if <4.5 cm, every 6 months if >4.5 cm
2. CTA or MRA
When is surgery (over endovascular repair) indicated for TAA?
Involvement of major aortic vessels (renal arteries)
What is the diagnostic criteria for POTS? What are treatment options?
Increase in HR of 30 beats/min or more, or an increase of HR >120/min within 10 minutes of standing
Behavioral modification, compression stockings, exercise training, increased fluid intake, beta blockers, fludocortisone, SSRIs, midodrine, pyridostigmine