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Hema Recall > Mixed > Flashcards

Mixed Flashcards

1
Q

Prognostic determinant for MDS and AML

A

MDS - Blast percentage
AML - Cytogenetic abnormalities

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2
Q

Chromosomal involvement in Alkylating agents and Topoisomerase II inhibitors

A

alkylating - 5 & 7
topoisomerase - 11

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3
Q

Minimum amount of iron to correct IDA

A

500 mg

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4
Q

Disease defined by MCHC > 34

A

Hereditary spherocytosis

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5
Q

2 microscopic features of megaloblastic anemia

A

Oval macrocytes
Segmented neutrophils

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6
Q

Cytogenetic abnormality in APL

A

t (15:17)

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7
Q

B-cell makers; T cell markers

A

CD 19, 20, 22, 23
CD5

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8
Q

CLL is associated with cancers and autoimmune infections. What are the associated cancers?

A

SBP

Skin
Breast
Prostate

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9
Q

Define Richter’s transformation

A

Transformation of CLL to DLBCL

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10
Q

RAI and BINET staging

A

RAI
Stage I (Low risk) - Lymphocytosis
Stage II/III (Intermediate) - Lymphocytosis and Lymphadenopathy
Stage IV (High) - Lymphocytosis, thrombocytopenia/anemia

BINET
A - < 3 LAD
B >= LAD
C Hgb < 10 and plt < 100, 000

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11
Q

Target Plt for CNS bleed

A

> 100

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12
Q

Severe thrombocytopenia in ITP

A

plt < 30

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13
Q

Tx of choice for severe ITP

A

Steroids and IVIG

Refractory: Rituximab

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14
Q

Pathogenesis of TTP

A

Decreased ADAMTS13

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15
Q

Mainstay if TTP management

A

Plasmapheresis until Plt normalizes for 2 days

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16
Q

Medication that can be given for aHUS

A

eculizumab

17
Q

When to treat CLL?

A

Symptomatic, meaning

> 6cm splenomegaly
=10 LAD
Autoimmune anemia/thrombocytopenia
Weight loss 10% in 6 months, fever, night sweats > 1 month
Progressive marrow failure

18
Q

Target Hgb and Hct in PV to avoid complications

A

M: Hgb < =140 Hct < 45
F: Hgb < =120 Hct < 42

19
Q

Percentage of blood loss with orthostatic hypotension

A

30%

20
Q

Formula for RPI

A

[Retic count % x (Hgb pt/Hgb normal)] / 2

21
Q

What is the most common cause of non-iatrogenic thrombocytopenia?

A

Infection

21
Q

What is the most common cause of non-iatrogenic thrombocytopenia?

A

Infection

Hema Recall (1 decks)

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