Mixed Flashcards
Cessation of smoking for at least __ weeks BEFORE and until _ days after surgery to reduce perioperative complications
8 weeks; 10 days
Pulsus paradoxus
Decrease in systolic pressure > 20 in inspiration
-Seen in conditions with increase in intrathoracic pressure
(COPD, Asthma, Tamponade, Pericardial dse
Causes of peripheral cyanosis?
Reduced cardiac output
Cold exposure
Redistribution of blood flow from extremities
Obstruction - arterial and venous
What level of CO2 would predispose to impending respiratory failure?
Normal or increasing
Characterize the 2 different types of asthma
Type I Brittle - persistent decline, OCS requiring, need for continuous Beta agonist infusion
Type II Brittle- may have precipitous, unpredictable falls
in lung function which may result in death? (HPIM
Causes of Loffler Syndrome?
“HAS”
Hookworm
Ascaris
Schistosomiasis
What is the suspected offending agent in a
patient presenting with symptoms similar to
pulmonary alveolar proteinosis and chest CT
demonstrates that characteristic crazy paving
pattern? (HPIM 20th ed. C283 P1979)
Silica
PaO2 will start to decrease in COPD px when FEV1 decreases to what percent? PaCO2 will increase when FEV1 decreases to what percent
O2 - 50%
CO2- 25%
Indication to NIPPV for COPD?
PaCO2 > 45 with absence of contraindications
What is the characteristic of pleural effusion seen
1 week post CABG? (HPIM 20th ed. C288 P2008,
Left sided and bloody
(with findings of eosinophils)
Weeks after post op
-Left sided, yellowish, with lymphocytes
Examples of drugs causing exudative pleural effusion?
DAN-B
Dasatinib
Amiodarone
Nitrofurantoin
Bromocriptine
Indications for NIPPV for Hypoventilation
PACO2 >= 45%
O2 sats <= 88% for consecutive 5 mins
FEV1 pred <= 50%
Inspiratory pressure < 60
Sniff pressure < 40
Risk factors for CA MRSA
Summer months
Young
Concurrent influenza
Erythematous rash
Gross hemoptysis
Cavitary infiltrate
Neutropenia
Critical risk factors for VAP development
-colonization
-Aspiration
-compromised immune response
SOFA scoring components
PFR
MAP
TB
Crea
UO
Plt
Which phase of ARDS is associated with rapid
recovery and liberation from mechanical ventilation?
Proliferative phase
What are non-B graded recommendation for ARDS
-Low tidal volume (A)
-Recruitment maneuvers (C) - indeterminate evidence
-Inhaled vasodilators (C)
-High frequency ventilation (D)
-Surfactant (D)
-Steroids (D)
Most common cause of transudative pleural effusion
Cirrhosis
MC cause of exudative PF?
Pneumonia
2nd malignancy
MC cause exudative PF
- Pneumonia
- Malignancy
Differentials for PF Glucose < 60
Bacterial infection
Malignancy
RA
DOC for Type 2 Brittle Asthma
SC epinephrine
DOC for Aspirin induced asthma
Inhaled corticosteroids
Anti leukotrienes can also be effective
Direct causes of ARDS
PAP-DT
Pneumonia
Aspiration
Pulmonary contusion
Drowning
Toxic inhalational injury
Close contact definition (2 or more)
Less than 1 meter
Exposure more than 15 mins
Poorly ventilated area
Formula for ROX INDEX
Sats/fio2 div RR
ROX index cutoffs
<2.8 at 2 hrs
<3.47 at 6 hrs
<3.85 at 12 hrs
Only agents in high risk CAP
S. Aureus
Pseudomonas aerginosa
What percentage of homogeneous deficiency of alpha 1 anti tryptase is homogeneous deficiency likely?
<20%
Percentage level when alpha tryptase deficiency should be treated?
<11%
CAT cut off that differentiates COPD functional capacity?
10
> = 10 means B or D
Differentials for platypnea
Left atrial myxoma
Hepatopulmonary disease
Definition of massive hemoptysis
400 mL in 24 hours OR 100-150 mL expectorated at one time
Atypical pathogen more common in VAP than CAP?
Legionella
According to HPIM, what is the target O2 sat in asthma?
> 90%
Describe dyspnea of EIA
occurs at end of exercise and continues until 30 mins after
prevented by B2 agonist and anti leukotrienes and ICS
Duration of witholding
-SABA
-ICS + LABA
-4 hrs
-24 hrs
Suspect this disease entity if suspecting asthma but refractory to conventional treatment
Allergic bronchopulmonary aspergillosis
MC cancer associated with asbestosis
Lung CA
Threshold for taking ABG
< 92%
Next step if pleural effusion shows negative cytology for malignancy?
Thoracoscopy
Most cases of chronic mediastinitis are due to which underlying disease?
TB
Parameters for failed SBT
HR > 140 or 20% inc/dec from baseline
RR > 35 for > 5 mins
O2 < 90%
SBP < 90 or > 180
Diaphoresis or increased anxiety
RR/TV > 105
Evidence grade C and D for ARDS
Grade C
-Inhaled vasodilators
-Recruitment maneuver
Grade D
-Steroids
-High frequency vent
-Surfactant
Good response with prone positioning
PF ratio > 20 of baseline
PaO2 > 10 of baseline
What antibiotics to add to CAP if with active or prior influenza infection during the past 2 weeks
Cover for MRSA
Linezolid 600 mg IV q12
Vancomycin 15 mg/kg IV q8-12
Diagnostic thresholds for endotracheal aspirate and protected brush specimen method?
Endotracheal -10^6
Protected specimen - 10^3
Repeat CXR sched for hospitalized CAP patients
After 4-6weeks
Treatment duration for
- bacteremic
- Mycoplasma Chlamydia
- LegionellA
-28 days
- 10-14
-14-21
Timeline regarding pneumonia progression
1 wk: resolution of fever
4 wks: chest pain and sputum production (4=pain)
6 weeks: cough and breathlessness
3 months: fatigue
6 months almost no symptoms
CURB 65 components and implications
Confusion
Urea >7 mmol/L
RR >= 30
BP <=90/60
Age 65
Positive sputum microscopy on the 2nd and 5th month of PTB treatment, what to do next?
2nd - do Gene Xpert then continue while waiting
5th - treatment failure. Stop meds. Refer to PMDT
Post bronchodilator spirometry med and time interval
SABA 400 mcg 10-15 mins
SAMA 160 mcg 30-45 mins
FEV1/FVC <0.7
Alpha 1 antitrypsin deficiency percentage defect
<20%
Indications for long time oxygen therapy in COPD
<= 88% O2 sat confirmed 2x over 3 week period
PaO2 <= 55 2x over 3 week period
PaO2 55-60 or 88% sar if with pulmo htn, polycythemia, edema
Parameters for clearance for air travel
O2sat >95%
6 MW > 84%
Next step of treatment if on max LABA LAMA ICS on COPD
Roflumilast if FEV1 <50 and with hx of exacerbation year before
Macrolide if prior smoker (erythromycin 250 mg BID OR Azithromycin 250 mg daily/500 mg 3 days a week)
Candidates for LVRS in COPD
Upper lobe emphysema with low post rehab exercise capacity
No benefit from LRVS in what subsept of population
FEV1 <20% and FeNO <20%
Diffusely distributed emphysema on CT
Indications for catheter related thrombolysis
If with extensive femoral, iliofemoral and Ue DVT
2 parenteral direct thrombin inhibitors
Argatroban
Bivalirudib
Acute isolated distal DVT management
If with symptoms = anticoagulation
If no symptoms and high bleeding risk = serial monitoring 2 weeks
Preferred access for thrombolysis
Peripheral over catheter