MITOSIS Flashcards
“Where a cell exists, there must have been a pre-existing cell, just as the animal arise only from an animal.”— name and year
Rudolf Virchow, 1855
Omnis cellula e cellula
every cell from a cell
The continuity of life based on the reproduction of cells
cell division
Functions of cell division
- asexual reproduction
- growth and development
- tissue renewal
example of asexual reproduction
amoeba, a single-celled eukaryote
example of growth and development
sand dollar embryo
example of tissue renewal
bone marrow cells
the cell division process is an integral part of—
cell cycle
the life of a cell from the time it is first formed during division of a parent cell until its own division into two daughter cells
cell cycle
why do biologists use the words sister/daughter in relation to cells
there is no relation
crucial function of cell division
passing identical genetic material to cellular offspring
reproduction of cell involves…
distribution of identical genetic material-DNA-to two daughter cells
a cell’s DNA, it’s genetic information is called
genome
in a typical human cell, what is the length of DNA, and about how many times is it greater than its diameter?
2 meters; 250,000 times greater
greek words and their meanings of “chromosomes” and the reason behind it
chroma - “color”
soma- “body”
reason: they take up certain dyes used in microscopy.
building material of chromosomes
chromatin
a eukaryotic chromosome consists of ________ associated with many ______.
one very long, linear DNA; proteins
the units of information that specify an organism’s inherited traits
genes
true or false: The DNA molecule carries several hundred to a few thousand genes.
true
functions of associated proteins of the chromosomes
maintains the structure and help control the activity of the genes
what are somatic cells?
all body cells except the reproductive cells
the nuclei of a human somatic cells contains how many chromosomes?
46
these cells have half as many chromosomes as somatic cells
gametes (reproductive cells)
how many chromosomes (somatic) are there in a
- cabbage plants
- chimpanzees
- elephants
- hedgehogs
- alga
respectively; 18 48 56 90 148
when a cell is not dividing, each chromosome is in the form of..
a long, thin chromatin fiber
after DNA replication, the chromosomes…
condense
each duplicated chromosome consists of ____ which are joined ___
two sister chromatids; copies of the original chromosome.
protein complexes that attaches two identical DNA all along their length _____ - this attachment is called __
cohesins; sister chromatid cohesion
a region made up of repetitive sequence in the chromosomal DNA where the chromatid is attached most closely to its sister chromatids
centromere
other bound proteins condense the DNA, giving the duplicated chromosome a
narrow “waist”
the portion of a chromatid to either side of centromere is referred to as an
arm of the chromatid
the division of the genetic material in the nucleus
mitosis
division of the cytoplasm
cytokinesis
meiosis occurs only in
special cells in the ovaries or testes (gonads)
this process fuses two gametes together and returns 23 chromosomes into 46 again
fertilization
He developed dyes that allowed him to observe the behavior of chromosomes during mitosis and cytokinesis and what year did he develop this
Walther Flemming, 1882
what terms did Flemming coin?
mitosis, chromatin
shortest part of the cell cycle that includes mitosis and cytokinesis
mitotic (M) phase
the mitotic phase alternates with a much longer stage called _______ which often accounts for about 90% of the cycle
interphase
Interphase can be divided into 3 phases namely
G1 phase (“first gap”), S phase (“synthesis”), G2 phase (“second gap”)
a cell grows by producing…
proteins and cytoplasmic organelles like mitochondria and ER
duplication of chromosomes, crucial for eventual division, occurs entirely in what phase?
S phase
matching type (G1, S, G2 or M phase)
- grows more as it completes preparations for cell division
- divides
- continues to grow as it copies its chromosomes
- a cell grows
- G2
- M
- S
- G1
M phase would occupy how many hours?
1 hour or less
S phase would occupy how many hours?
10-12 hours/half of the cycle
G2 phase would occupy how many hours?
4-6 hours
The phase that is the most variable in length in different types of cells
G1 phase
G1 phase would occupy how many hours?
5-6 hours
stages of mitosis:
prophase, prometaphase, metaphase, anaphase, telophase
consists of fibers made of microtubules and associated proteins; many of the events of mitosis depend on this
mitotic spindle
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the chromatin fibers become more tightly coiled, condensing into discrete chromosomes observable with a light microscope
prophase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the centrosomes are now at opposite poles of the cell
metaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the nuclear envelope fragments
prometaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the centrosomes move away from each other, propelled partly by the lengthening microtubules between them.
prophase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- a nuclear envelope encloses the nucleus.
G2 phase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- nucleoli reappers
telophase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- shortest stage of mitosis, lasting only a few minutes
anaphase
a plane that is equidistant between the spindle’s two poles; where the chromosomes’ centromeres lie
metaphase plate
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the chromosomes have arrived at the metaphase plate
metaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the cell elongates as the nonkinetochore microtubules lengthen
anaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the chromosomes become less condensed
telophase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- a kinetochore has now formed at the centromere of each chromatid
prometaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the nucleus contains one or more nucleoli
G2 phase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the chromosomes have become even more condensed
prometaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- by the end of this, the two ends of the cell have equivalent and complete collections of chromosomes
anaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- any remaining spindle microtubules are depolymerized
telophase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the nucleoli disappear
prophase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- for each chromosome, the kinetochores of the sister chromatids are attached to kinetochore microtubules coming from opposite poles.
metaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- mitosis is now complete
telophase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- it begins when the cohesion proteins are cleaved. this allows the two sister chromatids of each pair to part suddenly. each chromatid thus becomes an independent chromosome
anaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- chromosomes, duplicated during the S phase, cannot be seen individually bc they have not yet condensed.
G2 phase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- some of the microtubules attach to the kinetochores, becoming “kinetochore microtubules”which jerk the chromosomes back and forth
prometaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- two centrosomes have formed by duplication of a single centrosome.
G2 phase
regions in animal cells that organize the microtubules of the spindle. each of this contains two ______
centrosomes; centrioles
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- nonkinetochore microtubules interact with those from the opposite pole of the spindle lengthening the cell.
prometaphase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- each duplicated chromosome appears as two identical sister chromatids joined at their centromeres
and in some species, all along their arms by cohesion
prophase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- two daughter nuclei form in the cell. Nipuclear envelopes arise from the fragments of the parent’s cell’s nuclear envelope and other portions of the endomembrane system
telophase
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the mitotic spindle begins to form. It is composed of the centrosomes and the microtubules that extend from them.
prophase
the radial arrays of shorter microtubules that extend from the centrosomes are called
asters (stars)
G2 PHASE, PROPHASE, PROMETAPHASE, METAPHASE, ANAPHASE, or TELOPHASE:
- the two new daughter cells begin moving toward opposite ends of the cell as their kinetochore microtubules shorten. Bc these microtubules are attached at the centromere region, the centromeres are pulled ahead of the arms
anaphase
the spindle microtubules elongate (polymerize) by ___
incorporating more subunits of the protein tubulin
a subcellular region containing material that functions throughout the cell cycle to organize the cell’s microtubules ( also a type of microtubule-organizing center)
centrosome
the spindle includes the
centrosomes, spindle microtubules, asters
a structure made up of proteins that have assembled on specific sections of DNA at each centromere.
kinetochore
true or false: the chromosomes’ two kinetochores face in the same direction
false; should be opposite
cohesins holding together the sister chromatids of each chromosome are cleaved by an enzyme called
separase