Mitocondria Flashcards

1
Q

Membrana externa

A

40% lípidos (similares a REL)
60% proteínas (transportadoras, oxidasas, cinasas)
Parecida membrana externa de bacteria

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1
Q

Funciones

A

-Bioenergía
-Síntesis de lípidos, proteínas y grupos hemo
-Regula Calcio
-Apoptosis
-Producción de especies reactivas de oxígeno (ROS)

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2
Q

Membrana Interna

A

20% lípidos
80% proteínas (transportadora, respiración celular)
(-) colesterol
MUCHA cardiolipina (bacterias)

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3
Q

Bioenergética

A
  1. Acetil-CoA entra a Krebs–> genera NADH
  2. Electrones de NADH –> cadena transportadora de electrones
  3. Gradiente de protones –> genera ATP
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4
Q

Resultado de la Bioenergética

A

O2 acepta electrones —> H2O
Se pueden generar ROS (especies reactivas de oxígeno)

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5
Q

Apoptosis

A
  1. Estímulos pro-apoptoticos –> activan Bax y Bak
  2. Bax y Bak forman poros en la mitocondria
  3. Liberación de Citocromo C
  4. Citocromo C libera induce factores apoptoticos
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6
Q

Fusión

A

Dinaminas separan mitocondria con GTPasas

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7
Q

Fisión

A

Dinaminas ensamblan mitocondria con GTPasas

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8
Q

ADN mitocondrial

A

13 mRNA
22 tRNA
2 rRNA

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9
Q

Efecto cuello de botella

A

Mutación en mitocondria

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10
Q

Bax y Bak función:

A

Hacen porinas en membrana mitocondrial y se libera citocromo C

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