Mitochondria Flashcards
True or False: most scientists believe that the mitochondria evolved from the ER.
False. The dominant theory is that an early cell engulfed a prokaryote that became the mitochondria.
How many membranes does the mitochondria have?
Two. An inner and outer.
The mitochondria has porins for transporting molecules. Are they on the inner or outer membrane?
The outer. It is permeable to ions and small molecules, while the inner is impermeable.
What are cristae?
They are folds in the inner membrane that increase surface area.
Where does the citric acid cycle occur in the mitochondria?
The mitochondria matrix.
True or False: there are ribosomes in the mitochondria.
True. They are used to translate mitochondrial DNA.
What is the typical result of defects in the mitochondrial network?
The progression of numerous neurodegenerative diseases (e.g., Parkinson’s, Alzheimer’s)
What is the mitochondrial network structured from?
A network of tubules that are mobile and can fuse with one another.
Explain the difference between mitochondrial fission and fusion.
Fission is a breakdown of one into two, and fusion is the combination of two into one.
True or False: matrix-destined proteins possess unique targeting presequence.
True
What is the function of cytosolic chaperones in mitochondrial import?
Its job is to recognize proteins to be imported into the mitochondria
True or False: matrix-destined proteins enter the mitochondria completely folded.
False. In order to pass into the porin, they must be partially unfolded.
What is the name of the complex used to recognize a matrix protein’s N-terminal presequence at the surface of the mitochondria?
The TOM complex
Where is the matrix protein passed after it has been recognized by the TOM complex at the surface of the mitochondria?
To the TIM23 complex in the inner membrane.
True or False: the TOM complex and the TIM23 complex are physically connected.
True. This allows for the protein to translocate across the outer and inner membrane sequentially.