Mitochondria

Question 1

What are the roles of these molecules in the mitochondria?
Polgammma:
MtSSb:
Twinkle:
Dloop:

Answer 1

Pol-y: proofreading pol, with exonuclease activity. Synthesized in nuclues

MtSSB: mitochondrial SSB protein

Twinkle: mtDNA helicase

D-loop: d-displacment sire where most of replication and transcription is controlled. Q

Question 2

Is mtDNA transcription more like prokaryotic or eukaryotic transcription?

Answer 2

Transcription is initiated from promoters that are polycistronic. More like prokaryotes.

Question 3

What does mtDNA transcription require?

Answer 3

MtRNApol.

TFAM (transcription activator)

Mitochondrial transcription factor B1/2