Missed Items

Question 1

This immunosuppressant therapy binds to the immunophilin FK-506 binding protein (FKBP) in the cytoplasm, forming a complex that binds and inhibits mTOR. Inhibition of mTOR signaling blocks interleukin-2 signal transduction and prevents cell cycle progression and lymphocyte proliferation.

Answer 1

Sirolimus

*inhibits IL2

Question 2

A chelating agent

First line Tx for arsenic poisoning

Answer 2

Dimercaprol (British anti-Lewisite)

Question 3

What kind of poisoning impairs cellular respiration and presents with abdominal pain, vomiting, diarrhea, hypotension and garlic odor on the breath? Insecticides and contaminated water are common sources of the poison.

Answer 3

Arsenic

*also causes QT elongation, hyperkeratosis, stocking-glove neuropathy

Question 4

Hallmark of this disease is autoantibodies against POSTsynaptic nicotinic acetylcholine receptors.

Answer 4

Myasthenia gravis

Question 5

Ehlers-Danlos is a group of hereditary disorders involving defective synthesis of . . .

Answer 5

Collagen

Question 6

Autoimmune disease resulting in decreased functional acetylcholine receptors on the postsynaptic terminal of the neuromuscular junction. Overall decrease in the end-plate potential resulting in decreased formation of muscular action potentials.

Answer 6

Myasthenia gravis

Question 7

Defects in fibillin-1 gene cause this classic autosomal dominant syndrome

Answer 7

Marfan

Question 8

An elderly pt with easy fatigability, constipation, back pain, elevated serum protein and azotemia raise suspicion for this malignancy

Answer 8

Multiple myeloma

Question 9

Large eosinophilic casts composed of Bence-Jones proteins due to excess excretion of free light chains seen in tubular lumen casts

Answer 9

Multiple Myeloma kidney nephropathy

Question 10

Pancytopenia
Bone marrow replaced by fat cells and marrow stroma
No splenomegaly on PE

Answer 10

Aplastic anemia

Question 11

What is Kehr’s sign?

Answer 11

Referred pain to the shoulder from irritation of C3,4,5

Question 12

Auer rods indicate differentiation of which cell line?

Answer 12

Myeloid

Question 13

What do Auer rods stain positive for?

Answer 13

Myeloperoxidase

Question 14

Name 3 Extrapyramidal side effects of antipsychotics

Answer 14

Acute dystonic reaction
Akathisia
Drug-induced parkinsonism

Question 15

Extrapyramidal SE of antipsychotics:

Sudden-onset, sustained muscle contractions

Answer 15

Acute dystonic reaction

Question 16

Extrapyramidal SE of antipsychotics:

Subjective restlessness with inability to sit still

Answer 16

Akathisia

Question 17

Extrapyramidal SE of antipsychotics:

Tremor, rigidity, bradykinesia, masked facies

Answer 17

Drug-induced parkinsonism

Question 18

Antipsychotic SEs:

Involuntary movements after chronic use

Answer 18

Tardive dyskinesia

Question 19

Antipsychotic SEs:

Fever, rigidity, mental status changes, autonomic instability

Answer 19

Neuroleptic malignant syndrome

Question 20

Nitrogen mustard-based chemotherapy that causes hemorrhagic cystitis

Answer 20

Cyclophosphamide and its analog Ifosfamide

Question 21

Cyclophosphamide and Ifosfamide cause the kidneys to metabolize this uroepithhelial toxin

Answer 21

Acrolein

Question 22

A sulfhydryl compound that binds and inactivates the toxic metabolites of the chemotherapy drugs in urine. (For example it binds Acrolein)

Answer 22

Mesna (2-mercaptoethanesulfonate)

Question 23

What is the name of the test that uses light microscopy to see if a sample is positive for Varicella Zoster Virus?

Answer 23

Tzanck smear

Question 24

Intranuclear inclusions in keratinocytes and multinucleated giant cells are positive for this test

Answer 24

Tzanck smear - Varicella Zoster Virus