Missed Associations from Rx Questions

Question 1

Thiazide Diuretics: Gout

Answer 1

Thiazide diuretics will waste sodium in the DCT, which in turn will decrease the EXCRETION of Uric Acid in the kidney.

This leads to URIC ACID RETENTION –> Acute Gouty Attack

Question 2

Pathogen that causes osteomyelitis in healthy patients

Answer 2

S. aureus

Question 3

Early HTN with hypokalemia and low RAAS activation

Answer 3

Liddle’s Syndrome

Question 4

What two drugs (that I know of so far) will present with 1st dose hypotension?

Answer 4

ACE-I

Prazocin

Question 5

Alpha-Synuclien deposits are found in what disorders?

Answer 5

Parkinson’s disease (+ NF tangles)

Lewy Body Dementia

Question 6

Aggregated Tau proteins are found in what disorders?

Answer 6

Pick’s Disease

Question 7

Neurofibrillary tangles are associated with what disorders?

Answer 7

Alzheimer’s disease (also associated with beta-amyloid deposits)

Question 8

Dantrolene is the drug administered for what 3 disorder?

Answer 8

Dantrolene is a drug administered for Malignant Hypertension.

You can have pure Malignant Hypertension, which is typically in reaction to a volatile anesthetic (like halothane) –> muscles

Neuroleptic Malignant Hypertension, typically seen in those patients with neuro-degenerative disorders (esp. LBD) and are given neuroleptic agents.

Serotonin Syndrome

Question 9

Mnemonic for Pellagra

Answer 9

Vitamin B3 has 3 Ds
Diarrhea
Dermatitis
Dementia

Question 10

Vitamin B1 Df.:

Answer 10

“Eyes, Lies, and Capsize”

INO
Confusion/confabulation
Ataxia

Commonly seen in alcoholics

Question 11

Mnemonic for TCADs overdose

Answer 11

The 3 C’s:

C: Convulsions
C: Cardiotoxicity
C: Coma

Question 12

Signaling pathway for _____ is the Mnemonic: FLAT ChAMP Can’t Get Going

Answer 12

Works through cAMP second messenger system

F: FSH
L: LH
A: ACTH
T: TSH

C: CRH
h: hCG
A: ADH
M: MSH
P: PTH
calcitonin
GHRH
glucagon

all of the anterior pituitary hormones are cAMP, with the exception of GH

Question 13

In what class are all the ligands for cGMP ®s?

Answer 13

The vasodilator group:

ANP
NO
EDRF

Question 14

Signaling pathway for ____is the Mnemonic:

VETTT CAP

Answer 14

IP3
VETTT CAP : INTRACELLULAR RECEPTORS!!!!
V: Vitamin D
E: Estrogen
T: Testosterone
T: T3
T: T4

C: Cortisol
A: Aldosterone
P: Progesterone

All sex hormones, and adrenal hormones, plus the bone vitamin and the thyroid hormones

Question 15

Which receptor ligands activate intrinsic tyrosine kinase ®?

Answer 15

MAP kinase Pathway Growth Factors:

Insulin
IGF-1
FGF
PDGF
EGF

Question 16

Which receptor ligands activate Receptor - associated tyrosine kinases?

Answer 16

PIG

P: Prolactin
I: Immunomodulators: cytokines, IL-2/ -6/ -8, IFN
G: GH

Question 17

Analgesics + new onset nephropathy symptoms - what is the formal diagnosis?

Answer 17

AIN –> Renal Papillary Necrosis