Miscellaneous

Question 1

Define Grade 3/4 AE

Answer 1

Grade 3: Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization required, disabling, limiting self-care ADL.

Grade 4: Life-threatening consequences, urgent intervention needed.

Question 2

What are the details of our PD-L1 staining protocol?

Answer 2

Ventana platform, if tumours have greater than 25% surface expression of PD-L1 of any intensity, call it positive. Less than 25%, negative.

Question 3

Define RECIST CR, PR, and SD.

Answer 3

Complete Response: Disaappearance of all target lesions.
Partial Response: At least a 30% decrease in the sum of diameters of target lesions.
Progressive Disease: At least a 20% increase in teh sum of diameters of target lesions.
Stable Disease: Neither PR nor PD.

Question 4

Animal evidence for not blocking PD-L2:

Answer 4

• Matsumoto blocked PD-L2 during allergen challenge in mice, saw increased AHR and Th2 cytokines
• Akbari showed a lack of PD-L2 in mice led to increased AHR and inflammation