Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm test 3 > misc cardio > Flashcards

misc cardio Flashcards

1
Q

Name the drug class and possible adverse effect of Ticlopidine

A

ADP Receptor Inhibitor (1st)

Neutropenia, thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Is Clopidogrel expensive?

A

No there is a generic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What should you advise patients when taking clopidogrel with other meds?

A

Potential PPI interaction that causes reduces efficacy (increased clot risk!)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Prasugrel is a ____ generation ADP receptor inhibitor. Name an advantage and a con.

A

No PPI reactions, but $$$$$.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Ticagrelor is what sort of drug? Why is good for emergency surgery? What is another advantage?

A

ADP receptor inhibitors
Works faster and lasts shorter
No PPI reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Compared to clopidogrel, is ticagrelor have quicker or slower reversibilty?

A

quicker reversibility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Unfractioned heparin is _______ derived and a strong organic ______.

A

porcine derived

acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Heparin inhibits Factors __a, __a and __a, and activates _____ III. How can it be administered?

A

9, 10, 12
antithrombin
IV and SQ (NOT PO)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Is unfractioned heparin safe to use during pregnancy?

A

yes, it does not cross the placenta.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the antidote for unfractioned heparin? Dose?

A

IV protamine, 1mg for 100units of H

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the standard dosing regimen for unfractioned heparin?

A

80u/kg bolus + 18u/kg/kr for maintenance and titrate upon a PPT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How do you monitor unfractioned heparin? why do you have to monitor it? how often do you monitor it?

A

PPT
unpredictable pharmokinetics
Test 6 hours after initiation or rate change.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What do you have to monitor while on unfractioned heparin?

A

platelets

Heparin Induced Thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is Lovenox?

A

Low molecular weight heparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How do you monitor LMWH?

A

Obtain anti-factor Xa levels 3-5 hours post SQ injection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is therapeutic for LMWH?

A

0.6-1u/mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the antidote for LMWH?

A

IV protamine (only blocks 60% of anti Xa activity).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Why is LMWH easier to manage?

A

Standard dose!

19
Q

Is HIT still a concern with LMWH?

A

It is less of a concern. But if a patient has a hx of HIT, do not try LMWH.

20
Q

What are the heprinoids?

A

Fondaparinux, Danaparoid, Hirufins, Argatroban

21
Q

How does Nesiritide work?

A

It is the peptide (human B-type natruretic) that senses stretch of the heart and makes you pee.

22
Q

Why would you use Nesiritide?

A

For acute decompensated CHF with dyspnea at rest

23
Q

What is dopamine? Which receptors does it work on?

A

Acts as a adrenergic agonist

Renal dopaminergic receptors, beta 1 and alpha 1 receptors

24
Q

If stimulated, what will the renal dopaminergic receptors cause?

A

increased renal blood flow secondary to VASODILATION

… increased urinary output as a result

25
Q

If stimulated, what do the alpha and beta receptors do?

A

Alpha 1 – vasoconstriction - increase BP

Beta - increase HR, force of contraction

26
Q

Dopamine effects are ________ dependent.

A

Dose dependent

27
Q

___mcg/kg/min for renal, beta 1 and alpha?

A

Renal 2-5 mcg/kg/min
Beta-1 5-10
Alpha-1 >10

28
Q

What are the two D’s?

A

Dopamine and Dobutamine

29
Q

What is the B for in dobutamine?, what is it indicated for?

A

Beta 1- agonist, CHF

30
Q

How is DA administered?

A

IV

31
Q

How do the GPIIB and IIIA Antagonists work? How are they administered?

A

block the final common pathway to platelet aggregation

IV

32
Q

Are the GP antagonists more or less potent than ASA (COX path) and Clopidogrel (ADP path)?

A

MORE

33
Q

What are some uses for the GP antagonists?

A

acute coronary syndromes

ajduncts in PCTA

34
Q

What are some examples of GP antagonists?

A

Reopro, Integrilin, Aggrasta

35
Q

What does TPA stand for? How do they work?

A

tissue plasminogen activators

they dissolve clots via plasmin

36
Q

What is plasmin?

A

endogenous fibrinolytic enzymeq

37
Q

What is the atomic bomb of anticoagulation?

A

TPA

38
Q

T or F, TPA has the ability to dissolve both normal and pathologic clots

A

T

39
Q

What is TPA an alternative of?

A

angioplasty

40
Q

How is TPA administered? When should it be given?

A

IV

Give ASAP. within 4hr of CP is ideal

41
Q

What are the contraindications of TPA?

A
  1. ICH
  2. intercranial trauma
  3. brain tumor
  4. major abdominal or thorax surgery
  5. major bleeding (GI)
42
Q

What are the precautions when using TPA?

A

pregnancy
recent surgery
HTN (>180s, >100d)
advanced age

43
Q

What are some examples of TPAs?

A

Alteplase, reteplase, tenecteplase, streptokinase

44
Q

What is different about streptokinase?

A

it is bacterial – more likely to pose allergic rxn

Pharm test 3 (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions