MISC

Question 1

Causes of Infectious mononucleosis (glandular fever)

Answer 1

• Epstein-Barr virus (HHV-4) - MC
• Less frequent causes include cytomegalovirus and HHV-6

Question 2

Who does infectious mononucleosis most common in

Answer 2

adolescents and young adults

Question 3

Classic triad of features in infectious mononucleosis

Answer 3

sore throat, pyrexia and lymphadenopathy persisting over 1 week

Question 4

features of infectious mononucleosis

Answer 4

• sore throat
• pyrexia
• lymphadenopathy
• malaise, headache
• splenomegaly
• a maculopapular, pruritic rash develops in around 99% of patients who take ampicillin/amoxicillin whilst they have infectious mononucleosis

Question 5

Diagnosis of infectious mononucleosis

Answer 5

• heterophil antibody test (Monospot test)
• deranged LFTs
• lymphocytosis - atypical lymphocytes
• haemolytic anaemia

Question 6

How is infectious mononucleosis managed

Answer 6

• Supportive: self-limiting and usually resolves after 2-4 weeks
• avoid playing contact sports for 4 weeks after having glandular fever to reduce the risk of splenic rupture

Question 7

Complications of infectious mononucleosis

Answer 7

• splenic rupture
• haemolytic anaemia
• chronic fatigue