miRNA roles

Question 1

miR-127

Answer 1

hypermethylation and silencing inhibits its ability to silence BCL6 oncogene activity

Question 2

miR-143-145

Answer 2

downregulation in colorectal cancer allows EMT and proliferation

Question 3

miR-34a

Answer 3

dysregulation in breast cancer stops its ability to inhibit EMT gene such as Nanog and allows expansion of CSCs

Question 4

miR-155

Answer 4

oncogenic miRNA that inhibits TSGs and SOCS proteins

Question 5

miR-17-92

Answer 5

oncogenic miRNAs upregulated by MYCN that inhibit nuclear receptors and lead to decreased differentiation of sympathetic nervous system differentiation in neuroblastoma

Question 6

let-7 and LIM28B

Answer 6

• let-7 is a tumour suppressor miRNA that inhibits pathways such as RAS
• LIM28B is upregulated by MYCN and alters let-7 processing
• inhibits let-7 activity and drives tumour progression