Minor ailments Flashcards
L15, 16, 17, 17A (164 cards)
L15
What is an allergy and What is an allergen?
An allergy is an immune system reaction to a harmless substance, classified as a hypersensitivity disorder.
An allergen is a substance that triggers an allergic reaction.
L15 Allergies
Name risk factors for allergies.
Heredity, gender, race, age, environmental factors (pollution, allergen levels, dietary changes).
L15 Allergies
Define atopy.
A genetic predisposition to produce IgE antibodies in response to allergens, affecting the nose, eyes, skin, and lungs.
L15 Allergies
List common allergens and examples.
Proteins (e.g., foreign serum, vaccines)
Plant pollens (e.g., rye grass, ragweed)
Foods (e.g., nuts, seafood)
Drugs (e.g., penicillin)
Insect products (e.g., bee venom)
L15 Allergies
What are the actions of histamine on H1 receptors?
Vasodilation (erythema)
Increased capillary permeability (oedema)
Smooth muscle contraction (bronchoconstriction, GI motility)
Stimulation of sensory nerves (itch)
Increased gland secretions (nasal, salivary)
L15 Allergies
What is allergic rhinitis?
Inflammation of the nasal lining causing sneezing, nasal discharge, and blockage, affecting 1 in 5 people in the UK
L15 Allergies
Differentiate between types of allergic rhinitis.
Seasonal (e.g., hay fever): Symptoms occur with outdoor allergens (e.g., pollen).
Perennial: Year-round symptoms caused by indoor allergens (e.g., dust mites).
Occupational: Work-related allergens (e.g., wood dust).
L15 Allergies
Name non-pharmacological strategies for managing allergic rhinitis.
Allergen avoidance (e.g., keeping windows closed)
Using wrap-around sunglasses
Regular cleaning to minimize allergens
L15 Allergies
What are pharmacological treatments for allergic rhinitis?
H1 receptor antagonists (antihistamines)
Mast cell stabilisers
Intranasal corticosteroids
Local vasoconstrictors
L15 Allergies
Differentiate between 1st and 2nd generation antihistamines.
1st Generation: Cross blood-brain barrier, cause sedation (e.g., chlorphenamine).
2nd Generation: More selective, less sedation (e.g., loratadine).
Q: What is the preferred generation for allergic rhinitis treatment?
A: 2nd generation due to reduced side effects and dosing frequency.
L15 Allergies
What are the roles of mast cell stabilisers in eye drops?
Prevent histamine release, used for itchy and runny eyes.
L15 Allergies
List examples of intranasal corticosteroids.
Beclometasone, budesonide, fluticasone, mometasone.
L15 Allergies
When should allergic rhinitis patients be referred?
Symptoms persist despite treatment
Sleep disruption
Nasal obstruction that doesn’t clear
Red flags (e.g., orbital cellulitis, recurrent nosebleeds)
L15: Allergies
What type of hypersensitivity reaction is responsible for most allergic responses?
a) Type I (Immediate)
b) Type II (Cytotoxic)
c) Type III (Immune complex-mediated)
d) Type IV (Delayed-type)
Answer: a) Type I (Immediate)
L15: Allergies
Which antibody is mainly involved in allergic reactions?
a) IgA
b) IgG
c) IgE
d) IgM
Answer: c) IgE
L15: Allergies
Which of the following is NOT a typical allergen?
a) Plant pollen
b) Bee venom
c) Animal dander
d) Insulin
Answer: d) Insulin
L15: Allergies
What is “Atopy”?
a) Acquired immunity to allergens
b) Genetic predisposition to produce IgE antibodies
c) Inflammatory response caused by viruses
d) A severe form of eczema
Answer: b) Genetic predisposition to produce IgE antibodies
L15: Allergies
Which symptom is MOST associated with allergic rhinitis?
a) Vomiting
b) Sneezing
c) Diarrhoea
d) Wheezing
Answer: b) Sneezing
L15: Allergies
The “Triple Response of Lewis” describes the skin’s reaction to:
a) Bacterial infection
b) Viral invasion
c) Mechanical injury and histamine release
d) Fungal infection
Answer: c) Mechanical injury and histamine release
L15: Allergies
Which is the correct order of the “Triple Response of Lewis”?
a) Flare → Red Line → Wheal
b) Wheal → Flare → Red Line
c) Red Line → Flare → Wheal
d) Flare → Wheal → Red Line
Answer: c) Red Line → Flare → Wheal
L15: Allergies
Which of the following is a 2nd generation antihistamine?
a) Chlorphenamine
b) Diphenhydramine
c) Cetirizine
d) Promethazine
Answer: c) Cetirizine
L15: Allergies
First-generation antihistamines are more likely to cause which side effect?
a) Hypertension
b) Drowsiness
c) Increased appetite
d) Liver damage
Answer: b) Drowsiness
L15: Allergies
What is rhinitis medicamentosa caused by?
a) Allergens
b) Prolonged use of nasal vasoconstrictors
c) Viral infections
d) Bacterial overgrowth in nasal mucosa
Answer: b) Prolonged use of nasal vasoconstrictors
L15: Allergies
Intranasal corticosteroids like fluticasone are used because they: a) Provide immediate relief within minutes
b) Reduce local inflammation with minimal systemic absorption
c) Cure the allergy permanently
d) Have strong antibacterial properties
Answer: b) Reduce local inflammation with minimal systemic absorption