Minimizing and controlling flares

Question 1

Impaired skin barrier function due to deficiency of

Answer 1

ceramides (Lipids)

Filaggrin (Protein)

Question 2

Benefits of moisturizers

Answer 2

Improve xerosis
Decreased pruritis
Prevent and reduced AD flares
Decrease need for anti-inflammatory meds. 
Reduce transepidermal water loss

Question 3

Components of moisturizer

Answer 3

emollient
occlusive
humectant

Question 4

Adverse effects steroids

Answer 4

Skin atrophy
Purpura
Telangiectasia
Striae
Focal hypertrichosis
Acneiform or rosacea like eruptions
Impaired wound healing. 
Allergic contact dermatitis
HPA suppresssion.

Question 5

Eg of topical calcineuriin inhibitors (TCI)

Answer 5

tacrolimus

picrolimus

Question 6

Indication for TCI

Answer 6

sensitive areas (eyelids)
AD that does not respond to TCS
Patients who cannot tolerated TCS
Preventative Rx 2-3 x weekly in predictable areas.

Question 7

Side effects TCI

Answer 7

Transient burning
Flushing of face with alcohol
? Skin cancer - no cases after 10 years of use.

Question 8

eg of topical PDE4 inhibitor

Answer 8

Crisaborole topical ointment 2%

Question 9

Top PDE4 Indication

Answer 9

Mild to moderate AD > 2

Question 10

Top PDE4 mechanism of actions

Answer 10

Blocks release inflammatory cytokines from T cells.

Question 11

Application Top PDE4

Answer 11

Affected areas twice daily

Question 12

Top PDE4 side effects

Answer 12

Application site pain
Dermatitis
Pruritis