Mini Exam 3 Flashcards
estradiol brand name
Estrace
estradiol drug class
Estrogen derivative
estradiol indication
breast cancer, metastatic; hypoestrogenism (female); osteoporosis prevention (female); prostate cancer, advanced; menopausal symptoms
estradiol target
estrogen receptor
estradiol target family and location
homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue
estradiol target normal role
as a homodimeric nuclear receptor, in the un-bound state, monomers of the receptor are sequestered in the cytoplasm by large chaperone protein complexes. upon binding of a ligand the receptor undergoes a conformational change which results in dissociation of the receptor from its chaperone proteins, nuclear localization, dimerization, DNA binding, and association with co-transcription factor, ultimately resulting in upregulation of genes involved in the development and maintenance of primary and secondary sex characteristics in biologic females
estradiol pharmacologic activity
agonist
conjugated equine estrogens brand name
Premarin
conjugated equine estrogens drug class
estrogen derivative
conjugated equine estrogens indication
metastatic breast cancer, female hypoestrogenism, female osteoporosis prevention, advanced prostate cancer, menopausal symptoms
conjugated equine estrogens target
estrogen receptor
conjugated equine estrogens target family and location
homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue
conjugated equine estrogens pharmacologic activity
agonist
ethinyl estradiol/ etonogestrel brand name
EluRyng; NuvaRing
ethinyl estradiol/ etonogestrel drug class
contraceptive; estrogen and progestin combination
ethinyl estradiol/ etonogestrel indication
contraception
etonogestrel target
progesterone and estrogen receptor
etonogestrel target family and location
homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue
etonogestrel pharmacologic activity
agonist
norgestimate brand name
Sprintec, Esarylla
norgetimate drug class
contraceptive; estrogen and progestin combination
norgestimate indication
contraception
norgestimate target
progesterone and estrogen receptor
norgestimate target family and location
homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue
norgestimate pharmacologic activity
agonist
drospirenone brand name
Yasmin, Jasmiel
drospirenone drug class
contraceptive; estrogen and progestin combination
drospirenone indicaion
contraception
drospirenone target
progesterone and estrogen receptor
drospirenone target family and location
homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue
drospirenone pharmacologic activity
agonist
norethindrone/ ferrous fumarate brand name
Lo Loestrin Fe
norethindrone class
contraceptive; estrogen and progestin combination
norethindrone indication
contraception
norethindrone target
progesterone and estrogen receptor
norethindrone target family and location
homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue
norethindrone pharmacologic activity
agonist
levonorgestrel brand name
N/A
levonorgestrel class
contraceptive; progestin
levonorgestrel indication
emergency contraception
levonorgestrel target
progesterone receptor
levonorgestrel target family and location
steroid nuclear receptor expressed in various tissue types
raloxifene brand name
Evista
raloxifene class
selective estrogen receptor modulator (SERM)
raloxifene indication
prevention and treatment of bone loss after menopause
raloxifene target
estrogen receptor
raloxifene target family and location
homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue
raloxifene pharmacologic activity
agonist/antagonist
raloxifene MOA
it acts like an estrogen agonist in the bone to prevent bone loss and has estrogen antagonist activity to block some estrogen effects in the breast and uterine tissues. raloxifene decreases bone resorption, increasing bone mineral density and decreasing fracture incidence
testosterone brand name
Androderm
testosterone class
Androgen
testosterone indication
delayed puberty; hypogonadism
testosterone target
androgen receptor
testosterone target family and location
homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue
testosterone pharmacologic activity
agonist
bicalutamide brand name
Casodex
bicalutamide class
antineoplastic agent, antiandrogen
bicalutamide indication
metastatic prostate cancer
bicalutamide target
androgen receptor
bicalutamide target family and location
homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue
bicalutamide pharmacologic activity
reversible, orthosteric antagonist
levothyroxine brand name
Synthroid