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phcy 503 > Mini Exam 3 > Flashcards

Mini Exam 3 Flashcards

1
Q

estradiol brand name

A

Estrace

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2
Q

estradiol drug class

A

Estrogen derivative

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3
Q

estradiol indication

A

breast cancer, metastatic; hypoestrogenism (female); osteoporosis prevention (female); prostate cancer, advanced; menopausal symptoms

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4
Q

estradiol target

A

estrogen receptor

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5
Q

estradiol target family and location

A

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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6
Q

estradiol target normal role

A

as a homodimeric nuclear receptor, in the un-bound state, monomers of the receptor are sequestered in the cytoplasm by large chaperone protein complexes. upon binding of a ligand the receptor undergoes a conformational change which results in dissociation of the receptor from its chaperone proteins, nuclear localization, dimerization, DNA binding, and association with co-transcription factor, ultimately resulting in upregulation of genes involved in the development and maintenance of primary and secondary sex characteristics in biologic females

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7
Q

estradiol pharmacologic activity

A

agonist

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8
Q

conjugated equine estrogens brand name

A

Premarin

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9
Q

conjugated equine estrogens drug class

A

estrogen derivative

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10
Q

conjugated equine estrogens indication

A

metastatic breast cancer, female hypoestrogenism, female osteoporosis prevention, advanced prostate cancer, menopausal symptoms

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11
Q

conjugated equine estrogens target

A

estrogen receptor

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12
Q

conjugated equine estrogens target family and location

A

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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13
Q

conjugated equine estrogens pharmacologic activity

A

agonist

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14
Q

ethinyl estradiol/ etonogestrel brand name

A

EluRyng; NuvaRing

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15
Q

ethinyl estradiol/ etonogestrel drug class

A

contraceptive; estrogen and progestin combination

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16
Q

ethinyl estradiol/ etonogestrel indication

A

contraception

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17
Q

etonogestrel target

A

progesterone and estrogen receptor

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18
Q

etonogestrel target family and location

A

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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19
Q

etonogestrel pharmacologic activity

A

agonist

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20
Q

norgestimate brand name

A

Sprintec, Esarylla

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21
Q

norgetimate drug class

A

contraceptive; estrogen and progestin combination

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22
Q

norgestimate indication

A

contraception

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23
Q

norgestimate target

A

progesterone and estrogen receptor

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24
Q

norgestimate target family and location

A

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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25
Q

norgestimate pharmacologic activity

A

agonist

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26
Q

drospirenone brand name

A

Yasmin, Jasmiel

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27
Q

drospirenone drug class

A

contraceptive; estrogen and progestin combination

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28
Q

drospirenone indicaion

A

contraception

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29
Q

drospirenone target

A

progesterone and estrogen receptor

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30
Q

drospirenone target family and location

A

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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31
Q

drospirenone pharmacologic activity

A

agonist

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32
Q

norethindrone/ ferrous fumarate brand name

A

Lo Loestrin Fe

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33
Q

norethindrone class

A

contraceptive; estrogen and progestin combination

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34
Q

norethindrone indication

A

contraception

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35
Q

norethindrone target

A

progesterone and estrogen receptor

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36
Q

norethindrone target family and location

A

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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37
Q

norethindrone pharmacologic activity

A

agonist

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38
Q

levonorgestrel brand name

A

N/A

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39
Q

levonorgestrel class

A

contraceptive; progestin

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40
Q

levonorgestrel indication

A

emergency contraception

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41
Q

levonorgestrel target

A

progesterone receptor

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42
Q

levonorgestrel target family and location

A

steroid nuclear receptor expressed in various tissue types

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43
Q

raloxifene brand name

A

Evista

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44
Q

raloxifene class

A

selective estrogen receptor modulator (SERM)

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45
Q

raloxifene indication

A

prevention and treatment of bone loss after menopause

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46
Q

raloxifene target

A

estrogen receptor

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47
Q

raloxifene target family and location

A

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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48
Q

raloxifene pharmacologic activity

A

agonist/antagonist

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49
Q

raloxifene MOA

A

it acts like an estrogen agonist in the bone to prevent bone loss and has estrogen antagonist activity to block some estrogen effects in the breast and uterine tissues. raloxifene decreases bone resorption, increasing bone mineral density and decreasing fracture incidence

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50
Q

testosterone brand name

A

Androderm

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51
Q

testosterone class

A

Androgen

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52
Q

testosterone indication

A

delayed puberty; hypogonadism

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53
Q

testosterone target

A

androgen receptor

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54
Q

testosterone target family and location

A

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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55
Q

testosterone pharmacologic activity

A

agonist

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56
Q

bicalutamide brand name

A

Casodex

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57
Q

bicalutamide class

A

antineoplastic agent, antiandrogen

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58
Q

bicalutamide indication

A

metastatic prostate cancer

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59
Q

bicalutamide target

A

androgen receptor

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60
Q

bicalutamide target family and location

A

homodimeric ligand activated nuclear receptor expressed in various tissue types including reproductive tissue

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61
Q

bicalutamide pharmacologic activity

A

reversible, orthosteric antagonist

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62
Q

levothyroxine brand name

A

Synthroid

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63
Q

insulin aspart brand

64
Q

insulin aspart class

A

insulin, rapid-acting

65
Q

insulin aspart indication

66
Q

insulin aspart target

A

insulin receptor

67
Q

insulin aspart target family and location

A

receptor tyrosine kinase expressed on the surface of muscle, adipose and liver cells

68
Q

insulin aspart pharmacologic activity

69
Q

insulin lispro brand

70
Q

insulin lispro class

A

insulin, rapid-acting

71
Q

insulin lispro indication

72
Q

insulin lispro target

A

insulin receptor

73
Q

insulin lispro target family and location

A

receptor tyrosine kinase expressed on the surface of muscle, adipose and liver cells

74
Q

insulin lispro pharmacologic activity

75
Q

insulin glargine brand

76
Q

insulin glargine class

A

long-acting insulin

77
Q

insulin glargine indication

78
Q

insulin glargine target

A

insulin receptor

79
Q

insulin glargine target family and location

A

receptor tyrosine kinase expressed on the surface of muscle, adipose and liver cells

80
Q

insulin glargine pharmacologic activity

81
Q

liraglutide brand

A

Victoza, Saxenda

82
Q

liraglutide class

A

antidiabetic agent, glucagon-like peptide-1 receptor agonist

83
Q

liraglutide indication

A

T2DM, chronic weight management

84
Q

liraglutide target

A

GLP-1 receptor

85
Q

liraglutide target family and location

A

GPCR on pancreatic beta cells

86
Q

liraglutide pharmacologic activity

87
Q

exenatide brand

A

Byetta, Bydureon

88
Q

exenatide class

A

antidiabetic agent, glucagon-like peptide-1 receptor agonist

89
Q

exenatide indication

90
Q

exenatide target

A

GLP-1 receptor

91
Q

exenatide target family and location

A

GPCR on pancreatic beta cells

92
Q

exenatide pharmacologic activity

93
Q

sitagliptin brand

94
Q

sitagliptin class

A

antidiabetic agent, DPP-4

95
Q

sitagliptin indication

96
Q

sitagliptin target

97
Q

sitagliptin target family and location

A

homodimeric peptidase on the surface of most cell types

98
Q

sitagliptin pharmacologic activity

A

reversible, competitive inhibitor

99
Q

pioglitazone brand

100
Q

pioglitazone drug class

A

antidiabetic agent; thiazolidinedione

101
Q

pioglitazone indication

102
Q

pioglitazone target

103
Q

pioglitazone target family and location

A

heterodimeric nuclear receptor in adipocytes

104
Q

pioglitazone pharmacologic activity

105
Q

glimepiride brand

106
Q

glimepiride class

A

antidiabetic agent, sulfonylurea

107
Q

glimepiride indication

108
Q

glimepiride target

A

ATP-sensitive K+ channel

109
Q

glimepiride target family and location

A

ion channel expressed on pancreatic beta cells

110
Q

glimepiride pharmacologic activity

A

reversible, allosteric blocker

111
Q

glyburide brand

A

Diabeta, Glynase

112
Q

glyburide class

A

antidiabetic agent, sulfonylurea

113
Q

glyburide indication

114
Q

glyburide target

A

ATP sensitive K+ channel

115
Q

glyburide target family and location

A

ion channel expressed on pancreatic beta cells

116
Q

glyburide pharmacologic activity

A

reversible, allosteric blocker

117
Q

glipizide brand

A

Glucotrol, Glucotrol XL

118
Q

glipizide drug class

A

antidiabetic agent, sulfonylurea

119
Q

glipizide indication

120
Q

glipizide target

A

ATP sensitive K+ channel

121
Q

glipizide target family and location

A

ion channel expressed on pancreatic beta cells

122
Q

glipizide pharmacologic activity

A

reversible, allosteric blocker

123
Q

canagliflozin brand

124
Q

canagliflozin drug class

A

antidiabetic agent, SGLT2

125
Q

canagliflozin indication

126
Q

canagliflozin target

127
Q

canagliflozin target family and location

A

transporter expressed on epithelical cells of the proximal tubule in the nephron

128
Q

canagliflozin pharmacologic activity

A

reversible inhibitor

129
Q

metformin brand

A

Glucophage, Glumetza, Riomet

130
Q

metformin class

A

antidiabetic agent, biguanide

131
Q

metformin indication

132
Q

metformin target

133
Q

metformin target family and location

A

heterotrimeric kinase expressed in cells

134
Q

metformin pharmacologic activity

135
Q

heparin brand

136
Q

heparin class

A

anticoagulant

137
Q

heparin indication

A

coagulation disorder

138
Q

heparin target

A

antithrombin III

139
Q

heparin target family and location

A

glycoprotein located in plasma

140
Q

heparin pharmacologic activity

141
Q

enoxaparin brand

142
Q

enoxaparin class

A

anticoagulant; anticoagulant, LMWH

143
Q

enoxaparin indication

A

anticoagulation: ACS, DVT, venous thromboembolism, phophylaxis

144
Q

enoxaparin target

A

antithombin III

145
Q

enoxaparin target family and location

A

glycoprotein located in plasma

146
Q

enoxaparin pharmacologic activity

147
Q

apixaban brand

148
Q

apixaban class

A

anticoagulant; anticoagulant, factor Xa Inhibitor; DOAC

149
Q

apixaban indication

A

anticoagulation:: DVT, Nonvalvular atrial fibrillation, post-op venous thromboprophylaxis following hip or knee replacement surgery, PE

150
Q

apixaban target

151
Q

apixaban target family and location

A

lydrolase enzyme in plasma

152
Q

apixaban pharmacologic activity

A

reversible inhibitor

153
Q

dabigatran brand

154
Q

dabigatran class

A

anticoagulant; direct thrombin inhibitor; DOAC

155
Q

dabigatran indication

A

anticoagulation; DVT and PE treatment prevention, nonvalvular atrial fibrillaiton, and venous thromboembolism phorphylaxis in tota hip arthroplasty

phcy 503 (2 decks)

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