Minerals Flashcards
Where do all minerals come from?
The Earth’s crust
What are minerals?
Inorganic elements that originate in the Earth, that cannot be made by living organisms.
Can minerals be made by humans and other living organisms?
No
For humans to absorb and use minerals they must first be bound to _________ ________ (containing carbon).
Organic compounds
Organic = a chemical structure containing _________.
Carbon
Inorganic = a chemical structure without _________.
Carbon
Where might inorganic materials be present?
In the water we drink
Inorganic materials are difficult to breakdown. We have to excrete them and our bodies treat them as toxins. True or false?
True
The electrons in inorganic materials spin counter clockwise (in the opposite direction) to those in the cells in our bodies, so they’re out of sync with us. This is why they’re not good for us. True or false?
True
Where do plants obtain minerals?
From the soil.
Where do animals obtain minerals?
From the soil and plants they eat.
The mineral levels in plants are only as good as the soil they’re grown in. True or false?
True
What amount of our body weight is made up of minerals?
4 - 5%
Where in the body are minerals found?
In all body tissues
Which 2 minerals make up the majority of the mineral content of our bodies (around 75%)?
Calcium and phosphorus
What are macro minerals?
Minerals that we need a lot of.
What are micro minerals?
Minerals that we only need in small amounts.
List 5 macro minerals.
- Calcium (Ca)
- Sodium (Na)
- Phosphorus (P)
- Magnesium (Mg)
- Potassium (K)
- Chloride (Cl)
- Sulphur (S)
List 5 trace minerals.
- Iron (Fe)
- Zinc (Zn)
- Iodine (I)
- Selenium (Se)
- Manganese (Mn)
- Molybdenum (Mo)
- Copper (Cu)
- Chromium (Cr)
- Boron (B)
- Fluoride (F)
- Silicon (Si)
What are trace minerals?
Minerals that we need in very small amounts.
What dosage of Zinc do we need each day to function?
15 mg
What dosage of chromium do we need each day to function?
25 - 35 mcg
Which mineral do we need to balance blood sugar and maintain insulin sensitivity?
Chromium
How do macro minerals exist in the body (in what form)?
In an ionic state (as cations or anions)
What are cations (in relation to minerals)?
Positively charged mineral ions
What are anions (in relation to minerals)?
Negatively charged mineral ions
Name 4 macro minerals that exist in the body as cations (positively charged ions).
- Sodium (Na+)
- Calcium (Ca2+)
- Potassium (K+)
- Magnesium (Mg2+)
Name 3 macro minerals that exist in the body as anions (negatively charged ions).
- Chlorine (as chloride) (Cl-)
- Sulphur (as sulphate) (S-)
- Phosphorus (as phosphate) (P-)
Ionic minerals never exist in the body on their own, they like to form bonds with others (cations bond with anions). True or false?
True
Give 3 examples of classic cation-anion bonded minerals in the body.
- Potassium Chloride
- Magnesium Sulphate
- Calcium Phosphate
What are phosphoproteins?
Amino acids that are bonded to phosphates/phosphorus.
Give an example of a phosphoprotein.
Casein
What are phospholipids?
Lipids / fats that are bonded to phosphates/phosphorus.
Give an example of a phospholipid.
Cell membranes
What are metalloenzymes?
Enzymes that contain a metal ion at their core.
Alcohol dehydrogenase is an example of a metalloenzyme that contains _____ at its core.
Zinc
Which mineral is required to make the enzyme that breaks down alcohol and aldehydes in the body?
Zinc
What is a metalloprotein?
A mineral bonded to a protein.
Give an example of a metalloprotein molecule.
Haemoglobin - Iron bound to a protein
Most minerals are absorbed in their ionic state, in the ______ __________.
Small intestine
Most minerals are absorbed in their ionic state, in the small intestine. Name a mineral that is the exception to this rule.
Iron
Minerals must be released from the organic compounds they’re bound to (i.e, food) in order to be used in the body. This process relies on _______ ______.
Stomach acid (digestive secretions)
What happens to unabsorbed minerals?
They’re excreted in the faeces
List 3 key functions of minerals.
- Nerve & muscle function
- Thyroid health
- Supporting immune health
- Building tissues (bone, teeth etc)
- Components of enzymes
- Production of ATP
Define ‘bioavailability’.
The amount of a substance that we’re able to utilise to active effect.
Several factors can affect mineral bioavailability. List 3 of them.
- Existing mineral status in the body
- Substances present in food (can enhance or inhibit availability)
- Other minerals present in food (competing with each other)
List 3 things that can lead to mineral depletion in the body.
- Chronic stress
- Poor dietary choices / food processing
- Excessive exercise
- Excess alcohol, sugar, caffeine
Give an example of a mineral needed in higher quantities during pregnancy and why.
Calcium. To build the skeleton of the baby.
Give an example of a substance that can enhance the bioavailability of iron.
Vitamin C
Give an example of something that can inhibit the bioavailability of iron, zinc and/or calcium
Phytates
Give some examples of foods that contain phytates.
Beans, grains, lentils, nuts and seeds
What are phytates?
Storage forms of phosphorus
Many minerals compete with other minerals for absorption, as they use the same pathways to get into the cell. Give 2 examples of competing minerals.
- Iron reduces Zinc absorption
2. Zinc reduces copper absorption
What is a ligand?
A molecule that binds to another molecule.
Minerals in supplements are rarely found as pure minerals - they’re found to carrier molecules called ______. Each carrier has unique characteristics that facilitate absorption.
Ligands
List 3 challenges when it comes to mineral supplementation.
- Tolerability
- Bioavailability
- Chemical reactivity
List 3 common organic mineral carriers (ligands).
Citrate, glycinate, ascorbate, gluconate
List 3 common inorganic mineral carriers (ligands).
Oxide, carbonate, sulphide, chloride
In the mineral carrier gluconate, what molecule/substance is used to bind to the mineral (to increase bioavailability and tolerability)?
Glucose
In the mineral carrier glycinate, what is used to bind to the mineral (to increase bioavailability and tolerability)?
The amino acid glycine
________ is the most abundant mineral in the body, accounting for 2% of bodyweight and 39% of the body’s mineral content.
Calcium
99% of Ca in the body is found in mineralised connective tissues, i.e, _______ and _______. The remaining 1% is found in extra-cellular fluid, muscles and other tissues.
Bones and teeth
Which 3 hormones work together to tightly regulate calcium levels in the body?
- Parathyroid hormone
- Vitamin D
- Calcitonin
Parathyroid hormone, vitamin D and calcitonin tightly regulate the levels of which macro mineral in the body?
Calcium
Which hormone up-regulates osteoclasts to increase blood calcium levels?
Parathyroid hormone.
Which hormone/vitamin up-regulates calcium absorption in the GIT when calcium levels are low?
Vitamin D
Which hormone draws calcium back out of the blood and into the bone, by blocking the action of parathyroid hormone?
Calcitonin
Calcium is found mostly in vegetable and dairy foods. However, vegetable sources have the highest bioavailability. True or false?
True
List 5 key food sources of calcium.
- Dark green leafy greens (i.e, kale, rocket)
- Seeds (i.e, sesame seeds)
- Nuts (i.e, almonds)
- Beans (i.e, edamame)
- Herbs/spices (i.e, sage, coriander)
- Sardines (incl bones)
- Dairy (i.e, full fat cows milk)
Vegetable foods have 2 x the bioavailability of calcium of dairy foods. True or false?
True
List 3 key functions of calcium in the body.
- Bone health
- Nerve cell signalling
- Muscle contraction
- Blood clotting
- Making neurotransmitters
Which 2 minerals bind together to build bones?
Calcium and phosphorus
During which lifestage(s) is high calcium intake most important?
Childhood and adolescence (when bones are growing)
Calcium binds to the _________ framework in bone, increasing its density.
Collagen
Which mineral is involved in nerve signalling?
Calcium
Which mineral plays a role in regulating cardiac muscle function and mediates vasoconstriction?
Calcium
Why is using calcium supplements considered controversial?
Because there are links to cardiovascular events, especially when linked to Mg deficiency (calcium contracts, magnesium relaxes).
An excess of which mineral can cause increased heart activity and arrhythmias?
Calcium
List 2 lifestyle factors that increase calcium levels in our body / give us healthy bones
- Sunshine - making plenty of vitamin D
2. Exercise - build muscle and bone density
Why do blood banks add calcium binding factors to blood?
To prevent the blood from clotting in the bag.
Ca ions are used to activate certain clotting factors.
Which mineral is an essential co-factor in the conversion of tryptophan to serotonin?
Calcium
Calcium is absorbed by all parts of the small intestine, but especially in the ___________ where conditions are more acidic.
Duodenum
Ca is absorbed both actively and passively. Active absorption is controlled by _________ in the form of calcitriol.
Vitamin D
Passive absorption of calcium occurs without vitamin D, when Ca is consumed. True or false?
True
What percentage of calcium remains unabsorbed and passes out in the faeces?
50 - 70%
Why is calcium deficiency (blood levels) incredibly rare?
Because blood levels are typically maintained, even with inadequate dietary intake, at the expense of bones.
Is loss of bone mineral density symptomatic or asymptomatic?
Asymptomatic
List 3 factors that inhibit absorption of calcium.
- Low vitamin D status
- Low stomach acid (Hcl dissolves calcium salts)
- GI dysfunction
- High intake of phytates / oxalates
List 3 factors that increase excretion of calcium.
- Menopause (low oestrogen)
- High caffeine intake
- Some medications
What are oxalates?
Tiny reactive molecules that bind to cations and form crystal compounds that then make the mineral unavailable.
List 3 foods that are high in oxalates.
- Spinach
- Swiss chard
- Beetroot
- Rhubarb
The supplementation of which mineral can present a risk of kidney stones and soft tissue calcification, especially when vitamins D and K are deficient?
Calcium.
Which of these is in organic form (well tolerated and absorbed), and which is in inorganic form (not well tolerated/absorbed):
Calcium carbonate
Calcium citrate
Calcium carbonate = inorganic (cheap & nasty)
Calcium citrate = organic (good)
Bone health and calcium homeostasis is controlled by __________.
Hormones.
Which 3 minerals compete with calcium for absorption?
Magnesium, Iron, Phosphorus
Calcium excess can only really be achieved via excessive supplementation or excessive consumption of dairy. True or false?
True
What is a cation?
A positively charged ion
What is the second most common cation found in the body after potassium?
Magnesium
Which mineral serves many body functions and is a co-factor in at least 300 enzymatic reactions?
Magnesium
The body contains approximately __ g of magnesium.
25g
It’s estimated that up to 80% of the body’s biochemistry relies on magnesium in some way. True or false?
True
Where is magnesium found in the body?
60% in bones
39% in cells and muscles
1% in blood serum
Haemoglobin (in blood) and chlorophyll (in plants) are almost identical in structure, with haemoglobin having 4 iron atoms at its core and chlorophyll having 4 _____ atoms at its core.
Magnesium
Magnesium is found in all ______ coloured plants, because it’s at the core of the chlorophyll molecule.
Green
Least 5 food sources of magnesium.
- Green leafy veggies (swiss chard, spinach)
- Pumpkin seeds
- Flax seeds
- Soy beans (and other green beans)
- Amaranth & buckwheat
- Cacao
In energy production, which mineral is needed to convert ADP to ATP?
Magnesium
________ is a mineral co-factor involved in the modulation of glucose transport; specifically it is needed for the activation of tyrosine kinase enzymes. Therefore it is essential for glucose metabolism and insulin sensitivity.
Magnesium
List 4 roles of magnesium within the body.
- Energy production - turning ADP to ATP
- Glucose metabolism and insulin sensitivity
- Nerve cell signalling
- Blood thinning
- Forming bony matrix and tooth enamel
- Muscle relaxing
- Sleep and calming
__________ is nature’s ‘relax’ mineral.
Magnesium
_______ opposes calcium when it comes to blood clotting. Ca promotes clotting, ___ inhibits it.
Magnesium Mg
Which mineral is used as a co-factor for GABA synthesis and in the serotonin-melatonin pathway?
Magnesium
Where is most magnesium absorbed?
In the distal small intestine (ileum)
Which organ primarily regulates magnesium homeostasis?
The kidneys
Why don’t serum Mg levels accurately reflect Mg status?
Because 99% of magnesium is stored within cells.
________ (especially from high-phytate-containing foods) and _________ may inhibit magnesium absorption.
Phosphate and calcium
_________ and fructose may enhance magnesium absorption.
Protein
What is a phytate?
A storage form of phosphorus, found in some foods.
Magnesium _______ can be very effective at relieving constipation.
Citrate
Magnesium ________ is one of the most effective forms of magnesium for restoring magnesium level in the cells.
Glycinate
Magnesium ______ can be very effective at reducing muscle tension issues and fibromyalgia.
Malate
Magnesium _______ is sometimes used for cardiovascular issues.
Taurate
Magnesium ______ is used in epsom salt baths.
Sulphate
Which type of magnesium is very poorly absorbed orally but has very effective absorption transdermally?
Magnesium sulphate (epsom salts)
What is the therapeutic dose of epsom salt per bath?
500g - 1kg (for 20 mins +)
Why wouldn’t you use high dose magnesium supplements in someone with hypotension?
Because Mg can have a blood pressure lowering effect.
List 5 symptoms of Mg insufficiency
- Fatigue
- Insomnia
- Muscle cramps, twitches, spasms
- Headaches / migraine
- Stress and anxiety
- Palpitations
Name a medication that depletes magnesium in the body.
The OCP
_____ is a co-factor in over 200 metalloenzymes involved in catalytic, structural and regulatory functions.
Zinc
What type of enzymes contain metal ions at their core?
Metalloenzymes
_____ is a co-factor in superoxide dismutase (SOD), a powerful antioxidant required by all cells exposed to oxygen.
Zinc
_____ is a co-factor in alcohol dehydrogenase, an enzyme that helps detoxify / breakdown alcohol in the body.
Zinc
Why does zinc requirement increase with intake of alcohol?
Because zinc is a co-factor in the production of alcohol dehydrogenase; the enzyme that detoxifies the alcohol.
Which mineral is a co-factor in carboxypeptidase, an enzyme involved in the digestion of proteins?
Zinc
____ is the most abundant intracellular trace element (about 2g stored)
Zinc
List 5 food sources of zinc
- Oysters (highest food source by far) & crab
- Sesame seeds
- Unrefined grains - rye, oats, amaranth,
- Legumes - chickpeas
- Red meat - calf’s liver
Which mineral is required for the production of sex hormones, and particularly male health.
Zinc
Which mineral is required for spermatogenesis?
Zinc
Which mineral inhibits 5a-reductase (the enzyme that converts testosterone to the more potent androgen DHT)?
Zinc
Which mineral is required for the conversion of T4 to T3?
Zinc