Miller Oncology Lectures Flashcards
Malignant bone lesions seen in age < 5
LCH (Letter-Siwe), LCH (Hand-Schuller-Christian), metastatic rhabdomyosarcom, metastatic neuroblastoma
Malignant bone lesions seen age 5-30
Ewing’s, osteosarcoma

Malignant bone lesions seen age >30
Chondrosarcoma, (BPKLT) metastases, lymphoma, myeloma, chordoma, adamantinoma

Benign bone lesions seen in age <5
Osteomyelitis, osteofibrous dysplasia
Benign bone lesions seen in age 5-30
Osteoid osteoma, osteoblastoma, chondroblastoma, ABC, LCH, osteofibrous dysplasia, NOF
Benign bone lesions seen in age >30
Giant cell, Pagets
t(11;22)
Ewing’s
t(X;18), SSX1-SYT
Synovial sarcoma
Rb and p53
Osteosarcoma
Soft tissue sarcomas that are treated with chemotherapy
Synovial sarcoma and rhabdomyosarcoma. Otherwise, other soft tissue sarcomas are treated with XRT and surgery only.
Sarcomas treated with chemo, surgery, chemo
Ewing’s sarcoma, intramedullary and periosteal osteosarcoma
Tumors treated with ORIF and XRT
Mets (BPKLT), myeloma and lymphoma
Tumors treated with intralesional resection
GCT, ABC, NOF, LCH, osteoblastoma, chondroblastoma
Tumor treated with RFA
osteoid osteoma that has failed NSAIDs
Tumors treated with wide excision and limb salvage
Chondrosarcoma, adamantinoma, chordoma, parosteal osteosarcoma and soft tissue sarcoma
Cardiotoxic chemo drug used for osteosarcoma and Ewing’s sarcoma
Doxorubicin
35 year old patient with history of Ewing’s treated with chemotherapy presents with fatigue, gum bleeding and bruising. What’s his diagnosis?
Post-chemotherapy leukemia, confirm with CBC with peripheral blood smear
Palliative XRT dose for mets
25-30 Gy
Pre-op XRT dose for soft tissue sarcoma, associated complications
50 Gy, perioperative wound healing complications
Post-op XRT dose for soft tissue sarcoma, associated complications
60 Gy, fibrosis, bone necrosis and fracture complications
HO prophylaxis XRT dose
5 Gy
Diaphyseal bone lesions
AEIOUY - Adamantinoma, eosinophilic granuloma, infection, osteoid osteoma/osteoblastoma, “U”-wings sarcoma, fYbrous dysplasia, lYmphoma, mYeloma
Top 2 locations for bony metastases
1) Spine via Batson’s plexus 2) Proximal femur
Enneking’s 4 questions
Location, what’s the tumor doing to the bone, what’s the bone doing to the tumor, what is the matrix of the lesion








































































































