Mild Asthma in Preschoolers, Children & Adolescents Flashcards
Definition of Asthma Severity
Is based on the level of treatment needed to maintain asthma control.
Severity can only be accurately determined when asthma is well controlled and adherence and correct inhaler technique have been accounted for
Age cut off for spirometry
6 years or older
Criteria for day time symptoms and need for reliever
less than or equal to 2 days a week
Definition of mild exacerbation
does not require
> systemic steroids,
an emergency department (ED) visit,
hospitalization.
Should you prescribe SABA only PRN for Very Mild/ Mild Asthma + Higher risk of exacerbation?
No
Young people considered at higher risk for exacerbation AND who need to be assessed for risk of exacerbation [beyond asthma severity]
are those who:
(1) Have any history of a previous severe
asthma exacerbation (i.e., requiring use of systemic steroids, or an
ED visit, or hospitalization);
(2) Have poorly controlled asthma;
(3) Over-use SABA (i.e., use more than two SABA
inhalers over a 1-year period); or
(4) Currently smoke. Passive exposure
to smoke and the inhalation of other substances (e.g., vaping,
cannabis)
Treatment of Asthma
1] Asthma Action Plan
2] Asthma Trigger Identification
3] Environmental Modifications Discussion
4] Treatment by Age + Severity
Very Mild Asthma, treatment required:
PRN SABA
Mild Asthma, treatment required:
Low-dose ICS (or LTRA) + PRN SABA or
PRN budesonide/formoterol
Moderate Asthma, treatment required:
Low-dose ICS + a second controller + PRN
SABA or
moderate doses of ICS +/− a second
controller
+ PRN SABA or
low-to-moderate-dose budesonide/
formoterol + PRN budesonide/formoterol
Severe Asthma, treatment required:
High-dose ICS + a second controller or
systemic
steroids for 50% of the previous year even if severe asthma is not controlled with this treatment
Preschooler [1 to 5 years] Doses Low
Beclomethasone
dipropionate HFA
(QVAR)…………………………….100
Budesonide*
(Pulmicort)………………………n/a
Ciclesonide*
(Alvesco)………………………..100
Fluticasone furoate*
(Arnuity)………………………….n/a
Fluticasone propionate
(Flovent, Aermony)………..<200
Mometasone furoate*
(Asthmanex)……………………n/a
Preschooler [1 to 5 years] Doses Medium
Beclomethasone
dipropionate HFA
(QVAR)…………………………….200
Budesonide*
(Pulmicort)………………………n/a
Ciclesonide*
(Alvesco)…………………………200
Fluticasone furoate*
(Arnuity)………………………….n/a
Fluticasone propionate
(Flovent, Aermony)…………………200-250
Mometasone furoate*
(Asthmanex)……………………n/a
Children [6 to 11 years] Doses Low
Beclomethasone
dipropionate HFA
(QVAR)………………………….≤200
Budesonide*
(Pulmicort)……………………≤400
Ciclesonide*
(Alvesco)……………………….≤200
Fluticasone furoate*
(Arnuity)………………………….n/a
Fluticasone propionate
(Flovent, Aermony)……………………..≤200
Mometasone furoate*
(Asthmanex)……………………100
Children [6 to 11 years] Doses Medium
Beclomethasone
dipropionate HFA
(QVAR)…………………..201 - 400
Budesonide*
(Pulmicort)……………..401 - 800
Ciclesonide*
(Alvesco)…………………201 - 400
Fluticasone furoate*
(Arnuity)………………………….n/a
Fluticasone propionate
(Flovent, Aermony)…201 - 400
Mometasone furoate*
(Asthmanex)…….≥200 to <400
Children [6 to 11 years] Doses High
Beclomethasone
dipropionate HFA
(QVAR)…………………………>400
Budesonide*
(Pulmicort)……………………>800
Ciclesonide*
(Alvesco)……………………….>400
Fluticasone furoate*
(Arnuity)…………………………n/a
Fluticasone propionate
(Flovent, Aermony)………..>400
Mometasone furoate*
(Asthmanex)………………….≥400
Adolescents & Adults [12 years and over] Doses Low
Beclomethasone
dipropionate HFA
(QVAR)………………………..≤200
Budesonide*
(Pulmicort)……………………≤400
Ciclesonide*
(Alvesco)……………………….≤200
Fluticasone furoate*
(Arnuity)……………………….100
Fluticasone propionate
(Flovent, Aermony)..≤250, 110
Mometasone furoate*
(Asthmanex)…………..100 - 200
Adolescents & Adults [12 years and over] Doses Medium
Beclomethasone
dipropionate HFA
(QVAR)……………………201 - 500
Budesonide*
(Pulmicort)……………..401 - 800
Ciclesonide*
(Alvesco)………………..201 - 400
Fluticasone furoate*
(Arnuity)……………………….n/a
Fluticasone propionate
(Flovent, Aermony)…………..251 – 500, 226
Mometasone furoate*
(Asthmanex)………..> 200 - 400
Adolescents & Adults [12 years and over] Doses High
Beclomethasone
dipropionate HFA
(QVAR)……………………….500 (max 800)
Budesonide*
(Pulmicort)…………………..> 800 (max 2,400)
Ciclesonide*
(Alvesco)……………………….>400 (max 800)
Fluticasone furoate*
(Arnuity)……………………….200 (max 200)
Fluticasone propionate
(Flovent, Aermony)……………………..>500 (max 2000)
Mometasone furoate*
(Asthmanex)…………………>400 (max 800)
Once daily dosing inhalers
Budesonide*
(Pulmicort)
Ciclesonide*
(Alvesco)
Fluticasone furoate*
(Arnuity)
Mometasone furoate*
(Asthmanex)
Low dose QVAR Preschoolers
Indication for
Beclomethasone
dipropionate HFA
(QVAR)
100
Medium dose QVAR in Preschoolers
Indication for
Beclomethasone
dipropionate HFA
(QVAR)
200
Low dose QVAR in Children, Adolescents and Adults
Indication for
Beclomethasone
dipropionate HFA
(QVAR)
≤200
Medium dose QVAR in Children
Indication for
Beclomethasone
dipropionate HFA
(QVAR)
201 - 400
High dose QVAR in Children
Indication for
Beclomethasone
dipropionate HFA
(QVAR)
> 400
Medium dose QVAR in Adolescents and Adults
Indication for
Beclomethasone
dipropionate HFA
(QVAR)
201 - 500
High dose QVAR in Adolescents and Adults
Indication for
Beclomethasone
dipropionate HFA
(QVAR)
500 - 800
Low dose Pulmicort in Children, Adolescents and Adults
Indication for Budesonide*
(Pulmicort)
≤400
Medium dose Pulmicort in Children, Adolescents and Adults
Indication for Budesonide*
(Pulmicort)
401–800
High dose Pulmicort in Children, Adolescents and Adults
Indication for Budesonide*
(Pulmicort)
> 800 to 2400
Low dose Alvesco in Preschoolers
Indication for Ciclesonide*
(Alvesco)
100
Medium dose Alvesco in Preschoolers
Indication for Ciclesonide*
(Alvesco)
200
Low dose Alvesco in Preschoolers, Adolescents and Adults
Indication for Ciclesonide*
(Alvesco)
≤200
Medium dose Alvesco in Preschoolers, Adolescents and Adults
Indication for Ciclesonide*
(Alvesco)
201–400
High dose Alvesco in Adolescents and Adults
Indication for Ciclesonide*
(Alvesco)
> 400 to 800
Low dose Arnuity in Adolescents and Adults
Indication for Fluticasone furoate*
(Arnuity)
100
High dose Arnuity in Adolescents and Adults
Indication for Fluticasone furoate*
(Arnuity)
200 [Max]
Low dose Flovent/ Aermony in Preschoolers
Indication for Fluticasone propionate
(Flovent, Aermony)
<200
Medium dose Flovent/ Aermony in Preschoolers
Indication for Fluticasone propionate
(Flovent, Aermony)
200 - 250
Low dose Flovent/ Aermony in Children
Indication for Fluticasone propionate
(Flovent, Aermony)
≤200
Medium dose Flovent/ Aermony in Children
Indication for Fluticasone propionate
(Flovent, Aermony)
201 - 400
High dose Flovent/ Aermony in Children
Indication for Fluticasone propionate
(Flovent, Aermony)
> 400
Low dose Flovent/ Aermony in Adolescents and Adults
Indication for Fluticasone propionate
(Flovent, Aermony)
≤250, 110
Medium dose Flovent/ Aermony in Adolescents and Adults
Indication for Fluticasone propionate
(Flovent, Aermony)
251–500, 226
High dose Flovent/ Aermony in Adolescents and Adults
Indication for Fluticasone propionate
(Flovent, Aermony)
> 500 to 2000
Low Asthmanex dose in Children
Indication for Mometasone furoate*
(Asthmanex)
100
Medium Dose Asthmanex in Children
Indication for Mometasone furoate*
(Asthmanex)
≥200 to <400
High Dose Asthmanex in Children
Indication for Mometasone furoate*
(Asthmanex)
≥400
Low Dose Asthmanex in Adolescents and Adults
Indication for Mometasone furoate*
(Asthmanex)
100−200
Medium Dose Asthmanex in Adolescents and Adults
Indication for Mometasone furoate*
(Asthmanex)
> 200–400
High Dose Asthmanex in Adolescents and Adults
Indication for Mometasone furoate*
(Asthmanex)
> 400 to 800
In well controlled asthma in preschoolers, children and adolescents
Daytime Symptoms
≤2 days per week
In well controlled asthma in preschoolers, children and adolescents
Nighttime Symptoms
< 1 night per week and mild
In well controlled asthma in preschoolers, children and adolescents
Physical Activity
Normal
In well controlled asthma in preschoolers, children and adolescents
Exacerbations
Mild & Infrequent [i.e. does not negatively impact quality of life]
In well controlled asthma in preschoolers, children and adolescents
Absence from work or school due to asthma
None
In well controlled asthma in preschoolers, children and adolescents
Need for a reliever [SABA or bud/form]
≤2 doses per week
In well controlled asthma in preschoolers, children and adolescents
FEV1 OR PEF
≥90% of personal best
In well controlled asthma in preschoolers, children and adolescents
PEF diurnal variation
<10% to15%
Age range with small decrease in growth rate with ICS daily use
[no - low impact longer-term max 1cm to 2cm decrease in final height]
5 - 15 years
Age range in which bud/form is NOT recommended
<12 y/o
Rationale for prescribing ICS dosing everytime SABA is taken
Harm mitigation in adults ≥18 years old.
Asthma Secondline Option
Daily leukotriene receptor antagonist
(LTRA) as an option for individuals of any age
Side Effects of Leukotriene receptor antagonist
(LTRA)
Neuropsychiatric side
effects, most commonly irritability, aggressiveness, anxiety, and
sleep disturbance
bud/form puffer approved for PRN use
200/6 mcg in adolescents
PRN bud/form SIG
1 puff PRN to a maximum of
6 puffs on one occasion, or 8 puffs per day