Migraine Prevention Flashcards
1
Q
Groups used for migraine prevention
A
Anticonvulsants Antidepressants Antiinflammatory B-Adrenoreceptor Antagonists Calcium channel blockers Serotonin receptor Antagonists \+ Others
2
Q
Anticonvulsant
A
Valproate, most videly used A.C
3
Q
Adverse effects - valproate
A
Sedation, tremor and weight gain
4
Q
Antidepressants - Groups that can be used
A
- SSRIs
- TCAs
- MAOIs
5
Q
SSRIs
- Name
- Adverse
A
- Fluoxetine
- Anxiety
Insomnia
Tremor
Anorexia
Sexual Dysfunction
6
Q
TCAs
- Name
- Adverse
A
- Amitriptyline
- Drowsines
Tremor
Anticholinergic effects (dry mouth, blurred vision, urinary retention)
7
Q
MAOIs
- Name
- Adverse
A
- Penelizine
- Hypertensive crisis
- if taken with tyramine foods
- if taken with sympathomimetic amine drugs
8
Q
M.O.A Antidepressants
A
Inhibition of serotonin reuptake -> Down regulation of postsynaptic serotonin receptos and compensatory increase in firing rate of serotonin neurons
9
Q
NSAIDs
A
Aspirin Naproxen Fenoprofen - Used for prevention and treatment* - Continuosly or intermittend basis to prevent predictable headaches
10
Q
M.O.A - NSAIDs
A
Blocks thromboxane synthesis and platelet aggregation -> decreased release of serotonin
11
Q
B-ADRENORECEPTOS ANTAGONISTS
A
Propanolol Timolol - M.O.A uncertain - May block vasodilation - May reduce platelet aggregation
12
Q
CALCIUM CHANNEL BLOCKERS
A
Verapamil Nimodipine - Less effective then other groups - M.O.A uncertain - May prevent vasoconstriction phase
13
Q
SEROTONIN RECEPTOR ANTAGONIST
A
Methysergide - DISCONTINUED*
- Too toxic
14
Q
Other drugs for prevention
A
Gabapentine - Moderate prevention og migrane, few adverse effect - M.O.A uncertain in migraine Botulinum - Recently approved for prevention - M.O.A uncertain in migrain
