Migraine Meds Flashcards
1
Q
Name the triptans
A
Sumatriptan
Zolmitriptan
Rizatriptan
Naratriptan
2
Q
What is the mechanism of action of triptans?
A
5-HT agonists
Bind 5-HT receptors –> inhibit release of mediators of inflammation (prostaglandins, histamine, substance P) –> decreased inflammation and prevention of vasodilation
3
Q
At what point will triptans not be effective in treating a migraine?
A
Once cutaneous allodynia has occurred
migraine treatment is a race to prevent cutaneous allodynia
4
Q
Which triptan is longer acting and better for use when recurrence is a problem?
A
Naratriptan
5
Q
What drug has a similar mechanism of action as Triptans and is also used to treat migraines?
A
Dihydroergotamine
5-HT agonist similar to triptans
Also interacts with dopaminergic and adrenergic receptors
