Migraine Control

Question 1

Pizotifen is a drug that taken to treat headaches such as migraine and recurrent throbbing headaches. What is the mechanism of action of this drug?

Answer 1

• acts as serotonin antagonist at the 5-HT2A and 5HT2C receptors
• acts as an antihistamine as well as some anticholinergic activity

Question 2

Pizotifen is a drug that taken to treat headaches such as migraine and recurrent throbbing headaches. It is though that it acts as a serotonin antagonist at the 5-HT2A and 5HT2C receptors and acts as an antihistamine as well as some anticholinergic activity. How is inhibiting the
5-HT2A and 5HT2C serotonin receptors effective in reducing headaches/migraines?

Answer 2

• reduces cranial vasoconstriction

- reduces serotonin-enhanced platelet function and aggregation