Midterms Flashcards
FC in FC fragment?
Fragment crystallizable
Glycoproteins found in the serum portion of the blood?
Immunoglobulins
Humoral branch of immune response?
Immunoglobulins
Fab?
Antigen Binding Fragment
L chains found in the urine of patients with multiple myeloma?
Bence-Jones Proteins
Two main types of L chains
Kappa (2) & Lambda (22)
A unique amino acid sequence that is common to all immunoglobulin molecules
A heavy chain that determines Ig class.
Isotype
Variation in constant region of both HC & LC.
Present in some individuals but not in others.
Allotype
Variation in variable region of both HC & LC.
Unique to a specific antibody molecule.
Idiotype
Region for flexibility which contains proline?
Hinge region
Extra heavy chain?
CH4
Heavy chain of IgG? IgA? IgM? IgD? IgE?
Gamma Alpha Mu Delta Epsilon
Good polymer?
IgM
Smallest, coating antibody, associated with secondary immune response?
IgG
Provide immunity for newborns?
IgG
IgG best compliment fixer?
IgG3
1st to be produced after antigenic stimulation
IgM
Major antibody for secretions
IgA
IgA type for serum? For secretions?
IgA1, IgA2
Ig for immunoregulation & found on surface of B cells
IgD
Ig that has affinity to basophils and mast cells
IgE
Reduction of Antibody (2)
2-mercaptoethanol
Dithiothreitol
Cut monomer into 3 parts exactly at the hinge region
Papain
Cut monomer below hinge region into 2 parts
Pepsin
Unrelated cytokines?
- Endogenous pyrogens?
- T cell growth factor?
- Stimulates B cells?
Interleukins
- IL1
- IL2
- IL6
Interfere in viral replication. Proteins produced by virally infected cells and protect neighboring cells. Which type is: -non specific? -consists of? -specific? -consists of?
Interferons Type 1 -Alpha (leukocytes) -Beta (fibroblast) Type 2 -Gamma (t cells)
Cytotoxic activity against tumor cells and virally infected cells.
Which type is produced by macrophages?
By CD41 & CD8 cells?
Tumor Necrosis Factors
TNF alpha
TNF beta
Enhances motility and promote migrations of WBC
Also known as chemotaxin
Chemokines
Released by platelets during coagulation
Betalysin
A set of proteins that play a role in cytolytic destruction of cellular antigens by specific antibody
Complement system
Order of discovery
C123456789
Order of activation via classical pathway
C142356789
Membrane attack complex (MAC)?
Final MAC?
56789
9
Heaviest because of its tri-molecular complex?
Components of complex?
What attaches these complexes together?
C1
Q, R, S
Calcium
Which complement proteins are not synthesized in the liver?
C1 (intestinal epithelial cell) Factor D (adipose)
Specific pathway which is initiated by IgG & IgM? Recognition unit? Activation unit? MAC? Electrolyte?
Classical pathway
C1
C4, C2, C3
C5-C9
C3 convertase?
C4b2a
C5 convertase?
C4b2a3b
Non-specific pathway/bypass pathway which is initiated by igA & activates factor D?
What is properdin pathway?
Electrolyte?
Alternative pathway
Stabilizer of C3 convertase
Magnesium
Pathway with no C1, mannose instead
Recognition unit?
Electrolyte?
Activation unit?
Lecitin pathway
MASP -1-2-3 complex
C5 convertase (C3b4b2a)
Inhibitors of MAC
Homologous Restriction Factor
MIRL/CD59?
Membrane Inhibitor of Reactive Lysis
