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Serology > Midterms > Flashcards

Midterms Flashcards

0
Q

FC in FC fragment?

A

Fragment crystallizable

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1
Q

Glycoproteins found in the serum portion of the blood?

A

Immunoglobulins

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3
Q

Humoral branch of immune response?

A

Immunoglobulins

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4
Q

Fab?

A

Antigen Binding Fragment

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5
Q

L chains found in the urine of patients with multiple myeloma?

A

Bence-Jones Proteins

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6
Q

Two main types of L chains

A

Kappa (2) & Lambda (22)

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7
Q

A unique amino acid sequence that is common to all immunoglobulin molecules
A heavy chain that determines Ig class.

A

Isotype

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8
Q

Variation in constant region of both HC & LC.

Present in some individuals but not in others.

A

Allotype

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9
Q

Variation in variable region of both HC & LC.

Unique to a specific antibody molecule.

A

Idiotype

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10
Q

Region for flexibility which contains proline?

A

Hinge region

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11
Q

Extra heavy chain?

A

CH4

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12
Q 
Heavy chain of IgG?
IgA?
IgM?
IgD?
IgE?
A 
Gamma
Alpha
Mu
Delta
Epsilon
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13
Q

Good polymer?

A

IgM

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14
Q

Smallest, coating antibody, associated with secondary immune response?

A

IgG

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15
Q

Provide immunity for newborns?

A

IgG

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16
Q

IgG best compliment fixer?

A

IgG3

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17
Q

1st to be produced after antigenic stimulation

A

IgM

18
Q

Major antibody for secretions

A

IgA

19
Q

IgA type for serum? For secretions?

A

IgA1, IgA2

20
Q

Ig for immunoregulation & found on surface of B cells

A

IgD

21
Q

Ig that has affinity to basophils and mast cells

A

IgE

22
Q

Reduction of Antibody (2)

A

2-mercaptoethanol

Dithiothreitol

23
Q

Cut monomer into 3 parts exactly at the hinge region

A

Papain

24
Q

Cut monomer below hinge region into 2 parts

A

Pepsin

25
Q

Unrelated cytokines?

  • Endogenous pyrogens?
  • T cell growth factor?
  • Stimulates B cells?
A

Interleukins

  • IL1
  • IL2
  • IL6
26
Q 
Interfere in viral replication.
Proteins produced by virally infected cells and protect neighboring cells.
Which type is:
-non specific?
-consists of?
-specific?
-consists of?
A 
Interferons
Type 1
-Alpha (leukocytes)
-Beta (fibroblast)
Type 2
-Gamma (t cells)
27
Q

Cytotoxic activity against tumor cells and virally infected cells.
Which type is produced by macrophages?
By CD41 & CD8 cells?

A

Tumor Necrosis Factors
TNF alpha
TNF beta

28
Q

Enhances motility and promote migrations of WBC

Also known as chemotaxin

A

Chemokines

29
Q

Released by platelets during coagulation

A

Betalysin

30
Q

A set of proteins that play a role in cytolytic destruction of cellular antigens by specific antibody

A

Complement system

31
Q

Order of discovery

A

C123456789

32
Q

Order of activation via classical pathway

A

C142356789

33
Q

Membrane attack complex (MAC)?

Final MAC?

A

56789

9

34
Q

Heaviest because of its tri-molecular complex?
Components of complex?
What attaches these complexes together?

A

C1
Q, R, S
Calcium

35
Q

Which complement proteins are not synthesized in the liver?

A 
C1 (intestinal epithelial cell)
Factor D (adipose)
36
Q 
Specific pathway which is initiated by IgG & IgM?
Recognition unit?
Activation unit?
MAC?
Electrolyte?
A

Classical pathway
C1
C4, C2, C3
C5-C9

37
Q

C3 convertase?

A

C4b2a

38
Q

C5 convertase?

A

C4b2a3b

39
Q

Non-specific pathway/bypass pathway which is initiated by igA & activates factor D?
What is properdin pathway?
Electrolyte?

A

Alternative pathway
Stabilizer of C3 convertase
Magnesium

40
Q

Pathway with no C1, mannose instead
Recognition unit?
Electrolyte?
Activation unit?

A

Lecitin pathway
MASP -1-2-3 complex
C5 convertase (C3b4b2a)

41
Q

Inhibitors of MAC

A

Homologous Restriction Factor

42
Q

MIRL/CD59?

A

Membrane Inhibitor of Reactive Lysis

Serology (1 decks)

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