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Pharm Ana LAB > (Midterm) POST-LAB > Flashcards

(Midterm) POST-LAB Flashcards

1
Q

Materials of Preparation and Standardization of 0.1 N AgNO3

A

● Silver Nitrate - Titrant
● NaCl - Precipitant/ Analyte
● Acetic acid- Reagents
● Methanol- Reagents
● Eosin Y- Indicator

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2
Q

Procedure of Preparation and Standardization of 0.1 N AgNO3

A
  1. Weigh Analyte
  2. Dissolve in water
  3. Add Acetic acid - Reagents
  4. Add Methanol- Reagents
  5. Add Indicator- Eosin Y
  6. Titrate with Titrant until end point
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2
Q

Reasons for Important Steps in Preparation and Standardization of 0.1 N AgNO3

A

● Heating to 110°C
● Kept in Amber-colored bottles
● Acetic acid and Methanol

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3
Q
  • Photosensitive
  • Expose to light= metallic silver
    = Clear-> Grayish black
A

Kept in Amber-colored bottles

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3
Q
  • Achieve the highest purity
  • evaporate volatile contaminants like water,
    or other volatile organic compound
A

Heating to 110°C

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4
Q

● Appearance of turbidity or precipitation
● Use of internal indicator
● Instrumental methods, i.e. potentiometric or
amperometric

A

Determination of End Point

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5
Q

● Type of Titration: Direct Precipitation
Titration
● Chemical Reaction: NaCl + AgNO3 ->
AgCl+NaNO3
● USP Specs/Requirements: 99%-100.5%
● Titer value: 5.844mg/ml
● Endpoint: Precipitation

A

Assay of Sodium Chloride in NaCl Injection

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6
Q

Assay of Sodium Chloride in NaCl Injection

● Type of Titration:____________
● Chemical Reaction:_________________
● USP Specs/Requirements: ____________
● Titer value: _______________
● Endpoint: _______________

A

● Direct Precipitation Titration
● NaCl + AgNO3 -> AgCl+NaNO3
● 99%-100.5%
● 5.844mg/ml
● Precipitation

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7
Q

metal ion combines with a molecule which can donate electrons.

A

Complex

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8
Q

combining molecules containing two or more groups that donate electrons

A

Chelate

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9
Q

EDTA means

A

Ethylene diamine tetra acetic acid

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10
Q

provides groups for attachment to metal ions

A

Ligand

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11
Q

Materials of Preparation and Standardization of 0.05 M Na EDTA

A

● Na EDTA powder: Titrant
● CaCO3: Primary standard/analyte
● Dil. HCl: Reagent
● NaOH TS: Reagent
● Hydroxynaphthol blue: Indicator

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12
Q

Preparation and Standardization of 0.05 M Na EDTA

● Na EDTA powder: _____________
● CaCO3: _____________
● Dil. HCl: __________________
● NaOH TS: ______________
● Hydroxynaphthol blue: ______________

A

● Titrant
● Primary standard/analyte
● Reagent
● Reagent
● Indicator

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13
Q

Preparation and Standardization of 0.1 N AgNO3

● Silver Nitrate - ___________
● NaCl - _____________
● Acetic acid- _____________
● Methanol- ______________
● Eosin Y- ________________

A

● Titrant
● Precipitant/ Analyte
● Reagents
● Reagents
● Indicator

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14
Q

Procedure of Preparation and Standardization of 0.05 M Na EDTA

A
  1. Weigh analyte
  2. Add water
  3. Add HCl: Diluted HCl or 3N HCl
  4. Dilute to mark with water
  5. Add 12mL of titrant
  6. Add NaOH TS
  7. Add a pinch of Indicator
  8. Titrate with titrant until endpoint
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15
Q

Reasons for Important Steps in Preparation and Standardization of 0.05 M Na EDTA

A

● Using of distilled water then adding Hydrochloric acid
● NaOH TS

16
Q

has low solubility, because of its ionic bond

A

CaCO3

17
Q

Why do you need to add water before HCl?

A
  • Avoid the loss of purity
  • neutralizer
  • avoid formation of crumps
18
Q

Neutralization for excess HCl

A

NaOH TS

18
Q

Materials of Assay of Calcium Carbonate Tablets

A

● CaCO3 tablets
● 3N HCl
● 0.05M EDTA
● Hydroxynaphthol blue
● NaOH solution

19
Q

widely used oxidizing titrant

A

Potassium permanganate

20
Q

Assay of Calcium CarbonateTablets

  • End point: ______________
  • Type of titration: ________________
  • Titer value: ___________
  • USP Spec: _____________
A
  • Blue solution
  • Direct Complexometric Titration
  • 5.004
  • 98.5 - 100.5
21
Q
  • Acts as self indicator
  • Very strong oxidizing agent
  • End point: Distinct pink color
A

Potassium permanganate

22
Q

Solutions of oxidizing agents should never
be titrated from Mohr burets, since the
oxidizing agent attacks the rubber and the
KMnO4 titer decreases.

A

Permanganate Methods

23
Q

the best standard to use in the standardization of potassium
permanganate =analyte for primary standard

A

Sodium oxalate

24
Q

must be added to prevent the formation of manganese dioxide

A

Sufficient sulfuric acid

25
Q

analyte for primary standard

A

Sodium oxalate

26
Q

Direct Titration Method
● Concentration is expressed in %w/v
● USP Requirement: 2.5 – 3.5% w/v of H2O2
● In this assay, H2O2 acts as reducing agent
but chemically it is an oxidizing agent.

A

ASSAY OF HYDROGEN PEROXIDE SOLUTION

27
Q

Procedure of Preparation and Standardization of 0.1 N Iodine VS

A
  1. Weigh the analyte/primary standard
  2. Add 1N NaOH then add water
  3. Add methyl orange TS
  4. Add diluted HCl until a yellow color is
    change into pink
  5. Add NaHCO3 then add water
  6. Add indicator
  7. Titrate with titrant until endpoint
27
Q

ASSAY OF HYDROGEN PEROXIDE SOLUTION

  • Titration Method:
  • Concentration:
  • USP Requirement:
  • In this assay, H2O2 acts as _____________
    but chemically it is an _____________
A
  • Direct Titration Method
  • expressed in %w/v
  • 2.5 – 3.5% w/v of H2O2
  • reducing agent, oxidizing agent
28
Q

Materials of Preparation and Standardization of 0.1 N IodineVS

A

● Iodine crystals
● KI
● Sodium hydroxide
● Arsenic trioxide (As2O3) – primary standard: Amphoteric
● Dil. HCl
● Sodium bicarbonate
● Starch TS - indicator

29
Q

Reasons for Important Steps of Preparation and Standardization of 0.1 N IodineVS

A
  • Preparation of volumetric solution
    ● Addition of potassium iodide (KI)
  • Standardization of volumetric solution
    ● Addition of NaOH
    ● Addition of HCl
    ● Addition of sodium carbonate
30
Q

Endpoint of Preparation and Standardization of 0.1 N Iodine VS

A

Permanent Bluish black or Black

31
Q
  • Complexation reaction
  • Improve solubility
A

Addition of potassium iodide (KI)

32
Q
  • To dissolve As2O3
  • To maintain the basic environment during
    titration
  • Reduction reaction = gaining electron
A

Addition of NaOH

33
Q
  • To prevent hydrolysis from basic environment
  • To stabilize the solution
A

Addition of HCl

34
Q

Materials of Assay of Ascorbic Acid

A

● Ascorbic acid (RM)
● Sulfuric acid
● Starch TS - indicator
● 0.1N Iodine solution VS
● End point: Permanent Deep-blue or Black
solution
● USP Requirements: 99% - 100.5%

35
Q
  • To neutralize solution
  • Oxidation reaction= Loses electrons
A

Addition of sodium carbonate

36
Q

Assay of Ascorbic Acid

● Ascorbic acid (RM)
● Sulfuric acid
● Starch TS - indicator
● 0.1N Iodine solution VS
● End point: Permanent Deep-blue or Black
solution
● USP Requirements: 99% - 100.5%

A

● Ascorbic acid (RM)
● Sulfuric acid
● Starch TS: ____________
● 0.1N Iodine solution VS
● End point: _______________
● USP Requirements: _________________

Pharm Ana LAB (2 decks)

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