MIDTERM EXAM REVIEW Flashcards
Bleeding time is used to evaluate the activity of:
Platelets
Which of the following test results is normal in a patient with classic Von willebrand’s disease?
Platelet count
No bleeding is observed in deficiency of which of the following factors?
XII (12)
Hemolytic Uremic syndrome is asscoiated with:
E. coli
Coagulation factors affected by Coumarin Drugs:
II, VII, IX, and X
Thrombotic thrombocytopenic purpura is characterized by
Increased platelet aggregation
A protein that plays a vital role in both coagulation and platelet aggregation
I
The defect characterizing Gray’s syndrome
Alpha Granule
Factor XIII is activated by which factor?
IIa
Factor V is a cofactor to factor X to activate factor II (T or F)
True
What clotting factors are inhibited by Protein S?
V and VIII
What is the second phase of secondary hemostasis?
Activation of factor X
Several hours after birth, a baby boy develops petechiae and a hemorrhagic diathesis. Platelet count is 18,000/uL. What is likely the explanation?
Isoimmune Neonatal Thrombocytopenia
When performing platelet aggregation studies, which is most likely associated with Bernard Soulier Syndrome?
Normal to Epinephrine, Decreased to Ristocetin
Which of the ff is a characteristic of acute idiopathic thrombocytopenic purpura?
Spontaneous remission within a few weeks
Factor XIII is a serine protease (T or F)
False
Which of the ff inhibitors inhibit Factor IIa?
Both (Protein C and Antithrombin III)
Which of the ff is correct regarding acquired thrombotic thrombocytopenic purpura?
Autoimmune Disease
TAFI target protein
Fibrin
Which step requires calcium?
Factor XIII activation
Giant Platelet is associated with which condition
Bernard Soulier Syndrome
Platelet abnormality will affect both bleeding time and clotting time (T or F)
True
Which of the ff is associated with post transfusion purpura?
Immune mediated thrombocytopenia/Alloantibodies
Thiazide diuretics results to
Decreased Platelet Production
Which of the ff factors is used only in the extrinsic coagualtion pathway?
VII
Hereditary hemorrhagic telangectasia is a disorder of?
Connective tissue
Which of the ff coagulation factors is considered to be labile?
V
What role does Vitamin K play in the Prothrombin group?
Carboxylates the factors to allow calcium binding
Factor I deficiency will affect APTT and PT (T or F)
True
Aspirin prevents platelet aggregation by inhibitng the action of which enzyme?
Cyclooxygenase
Which statement regarding protein C is correct?
Activity is enhanced by Protein S
Thrombocytopenia may be associated with
Hypersplenism
The APTT is sensitive to a deficiency of which clotting factor?
None
Which of the ff factors will activate factor XI?
Haegman factor
Lumi-aggregation measures?
Aggregation and ATP release
APTT is used to?
Both (Monitor Heparin Therapy, Evaluate the Common Pathway)
Neurologic findings may be commonly assoicated with which of the ff disorders?
TTP
True of TTP and DIC
ATPP prolonged in DIC
Which of the ff tests is most likely to be abnormal in patients taking Aspirin?
Bleeding time
Platelet aggregation response for Glannzmann’s Thrombasthenia:
Normal to Ristocetin, Decreased to Epinephrine
Thrombin-Thrombomodulin complex is necessary for the actiavtion of
Protein C
Scott Syndrome will affect which of the ff?
Secondary Hemostatis
