MIDTERM EXAM REVIEW

Question 1

Bleeding time is used to evaluate the activity of:

Answer 1

Platelets

Question 2

Which of the following test results is normal in a patient with classic Von willebrand’s disease?

Answer 2

Platelet count

Question 3

No bleeding is observed in deficiency of which of the following factors?

Answer 3

XII (12)

Question 4

Hemolytic Uremic syndrome is asscoiated with:

Answer 4

E. coli

Question 5

Coagulation factors affected by Coumarin Drugs:

Answer 5

II, VII, IX, and X

Question 6

Thrombotic thrombocytopenic purpura is characterized by

Answer 6

Increased platelet aggregation

Question 7

A protein that plays a vital role in both coagulation and platelet aggregation

Answer 7

I

Question 8

The defect characterizing Gray’s syndrome

Answer 8

Alpha Granule

Question 9

Factor XIII is activated by which factor?

Answer 9

IIa

Question 10

Factor V is a cofactor to factor X to activate factor II (T or F)

Answer 10

True

Question 11

What clotting factors are inhibited by Protein S?

Answer 11

V and VIII

Question 12

What is the second phase of secondary hemostasis?

Answer 12

Activation of factor X

Question 13

Several hours after birth, a baby boy develops petechiae and a hemorrhagic diathesis. Platelet count is 18,000/uL. What is likely the explanation?

Answer 13

Isoimmune Neonatal Thrombocytopenia

Question 14

When performing platelet aggregation studies, which is most likely associated with Bernard Soulier Syndrome?

Answer 14

Normal to Epinephrine, Decreased to Ristocetin

Question 15

Which of the ff is a characteristic of acute idiopathic thrombocytopenic purpura?

Answer 15

Spontaneous remission within a few weeks

Question 16

Factor XIII is a serine protease (T or F)

Answer 16

False

Question 17

Which of the ff inhibitors inhibit Factor IIa?

Answer 17

Both (Protein C and Antithrombin III)

Question 18

Which of the ff is correct regarding acquired thrombotic thrombocytopenic purpura?

Answer 18

Autoimmune Disease

Question 19

TAFI target protein

Answer 19

Fibrin

Question 20

Which step requires calcium?

Answer 20

Factor XIII activation

Question 21

Giant Platelet is associated with which condition

Answer 21

Bernard Soulier Syndrome

Question 22

Platelet abnormality will affect both bleeding time and clotting time (T or F)

Answer 22

True

Question 23

Which of the ff is associated with post transfusion purpura?

Answer 23

Immune mediated thrombocytopenia/Alloantibodies

Question 24

Thiazide diuretics results to

Answer 24

Decreased Platelet Production

Question 25

Which of the ff factors is used only in the extrinsic coagualtion pathway?

Answer 25

VII

Question 26

Hereditary hemorrhagic telangectasia is a disorder of?

Answer 26

Connective tissue

Question 27

Which of the ff coagulation factors is considered to be labile?

Answer 27

V

Question 28

What role does Vitamin K play in the Prothrombin group?

Answer 28

Carboxylates the factors to allow calcium binding

Question 29

Factor I deficiency will affect APTT and PT (T or F)

Answer 29

True

Question 30

Aspirin prevents platelet aggregation by inhibitng the action of which enzyme?

Answer 30

Cyclooxygenase

Question 31

Which statement regarding protein C is correct?

Answer 31

Activity is enhanced by Protein S

Question 32

Thrombocytopenia may be associated with

Answer 32

Hypersplenism

Question 33

The APTT is sensitive to a deficiency of which clotting factor?

Answer 33

None

Question 34

Which of the ff factors will activate factor XI?

Answer 34

Haegman factor

Question 35

Lumi-aggregation measures?

Answer 35

Aggregation and ATP release

Question 36

APTT is used to?

Answer 36

Both (Monitor Heparin Therapy, Evaluate the Common Pathway)

Question 37

Neurologic findings may be commonly assoicated with which of the ff disorders?

Answer 37

TTP

Question 38

True of TTP and DIC

Answer 38

ATPP prolonged in DIC

Question 39

Which of the ff tests is most likely to be abnormal in patients taking Aspirin?

Answer 39

Bleeding time

Question 40

Platelet aggregation response for Glannzmann's Thrombasthenia:

Answer 40

Normal to Ristocetin, Decreased to Epinephrine

Question 41

Thrombin-Thrombomodulin complex is necessary for the actiavtion of

Answer 41

Protein C

Question 42

Scott Syndrome will affect which of the ff?

Answer 42

Secondary Hemostatis