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HEMA LEC > MIDTERM EXAM REVIEW > Flashcards

MIDTERM EXAM REVIEW Flashcards

1
Q

Bleeding time is used to evaluate the activity of:

A

Platelets

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2
Q

Which of the following test results is normal in a patient with classic Von willebrand’s disease?

A

Platelet count

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3
Q

No bleeding is observed in deficiency of which of the following factors?

A

XII (12)

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4
Q

Hemolytic Uremic syndrome is asscoiated with:

A

E. coli

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5
Q

Coagulation factors affected by Coumarin Drugs:

A

II, VII, IX, and X

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6
Q

Thrombotic thrombocytopenic purpura is characterized by

A

Increased platelet aggregation

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7
Q

A protein that plays a vital role in both coagulation and platelet aggregation

A

I

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8
Q

The defect characterizing Gray’s syndrome

A

Alpha Granule

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9
Q

Factor XIII is activated by which factor?

A

IIa

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10
Q

Factor V is a cofactor to factor X to activate factor II (T or F)

A

True

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11
Q

What clotting factors are inhibited by Protein S?

A

V and VIII

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12
Q

What is the second phase of secondary hemostasis?

A

Activation of factor X

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13
Q

Several hours after birth, a baby boy develops petechiae and a hemorrhagic diathesis. Platelet count is 18,000/uL. What is likely the explanation?

A

Isoimmune Neonatal Thrombocytopenia

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14
Q

When performing platelet aggregation studies, which is most likely associated with Bernard Soulier Syndrome?

A

Normal to Epinephrine, Decreased to Ristocetin

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15
Q

Which of the ff is a characteristic of acute idiopathic thrombocytopenic purpura?

A

Spontaneous remission within a few weeks

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16
Q

Factor XIII is a serine protease (T or F)

A

False

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17
Q

Which of the ff inhibitors inhibit Factor IIa?

A

Both (Protein C and Antithrombin III)

18
Q

Which of the ff is correct regarding acquired thrombotic thrombocytopenic purpura?

A

Autoimmune Disease

19
Q

TAFI target protein

A

Fibrin

20
Q

Which step requires calcium?

A

Factor XIII activation

21
Q

Giant Platelet is associated with which condition

A

Bernard Soulier Syndrome

22
Q

Platelet abnormality will affect both bleeding time and clotting time (T or F)

A

True

23
Q

Which of the ff is associated with post transfusion purpura?

A

Immune mediated thrombocytopenia/Alloantibodies

24
Q

Thiazide diuretics results to

A

Decreased Platelet Production

25
Q

Which of the ff factors is used only in the extrinsic coagualtion pathway?

A

VII

26
Q

Hereditary hemorrhagic telangectasia is a disorder of?

A

Connective tissue

27
Q

Which of the ff coagulation factors is considered to be labile?

A

V

28
Q

What role does Vitamin K play in the Prothrombin group?

A

Carboxylates the factors to allow calcium binding

29
Q

Factor I deficiency will affect APTT and PT (T or F)

A

True

30
Q

Aspirin prevents platelet aggregation by inhibitng the action of which enzyme?

A

Cyclooxygenase

31
Q

Which statement regarding protein C is correct?

A

Activity is enhanced by Protein S

32
Q

Thrombocytopenia may be associated with

A

Hypersplenism

33
Q

The APTT is sensitive to a deficiency of which clotting factor?

A

None

34
Q

Which of the ff factors will activate factor XI?

A

Haegman factor

35
Q

Lumi-aggregation measures?

A

Aggregation and ATP release

36
Q

APTT is used to?

A

Both (Monitor Heparin Therapy, Evaluate the Common Pathway)

37
Q

Neurologic findings may be commonly assoicated with which of the ff disorders?

A

TTP

38
Q

True of TTP and DIC

A

ATPP prolonged in DIC

39
Q

Which of the ff tests is most likely to be abnormal in patients taking Aspirin?

A

Bleeding time

40
Q

Platelet aggregation response for Glannzmann’s Thrombasthenia:

A

Normal to Ristocetin, Decreased to Epinephrine

41
Q

Thrombin-Thrombomodulin complex is necessary for the actiavtion of

A

Protein C

42
Q

Scott Syndrome will affect which of the ff?

A

Secondary Hemostatis

HEMA LEC (1 decks)

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