Midterm AUC, Distribution

Question 1

Pharmaceutical Factors:

Answer 1

Particle size
Salt form
Crystal forms
Water of hydration
Nature of Excipients & Adjuvants
Degree of Ionization

Question 2

In vivo Bioavailability Principles:

Answer 2

• no unnecessary human research
• normal adult population & standardized conditions
• not critically ill (unless w/ potential benefit to the patient by attending physician)