midterm Flashcards
what is research
process of investigation
involves examination of subject from diff points of view
reaserch is a goal directed process that is (), (). and ()
organized, objective reliable (reproducible)
research IS NOT
proving the efficacy of effectiveness of a treatmetn
besides being scientific and medical research, research can also be () () ()
questionnaires, surveys, studies that study (how people interact, habits)
why research 3
starting point for all medical progress
helped us understand avoiding risky behavirous to prevent disease
undersatn early diagnosis and appropriate treatment can prevent
reaserch literacy is the ability to waht
find, understand, critically evaluate research evidence for application in professional practice
reaserch capacity is the ability to
conduct research
method mean
systematic procedure for carrying out an acitivity
2 importance of research methods
to select therapeutic procedure for ur patient
to systematically compare effectivemess of new procedures
() () () are fundamental to any profession
experimental design, research methods, statistical analysis
ebm eveidence based medicine is the integration of 3 things
individual clinical expertise
best available external clinical evidence
patients values and expectations
from bottom up name the diff studies based on least reliable to most
least: background info/expert opionin UNFILTERED INFO: case-series case-controlled studies cohort studies RCT FILITERD INFO: critically approved individual articles (article synopses) critically appraised topics (evidence syntheses) systematic reviews BEST
definition of ebm
the conscientious/careful explicit and judicious use of current best evidence in making decisions about the care of individual patients
5 steps to provide e-b care
1.ask an answerable question
2. searching for best evidence
3. critically aprasing the evidence
4 integrate the evidtence with our expertise and patients biology and values
5 evaluate our performance
the 5 A’s for ebm
asking, acquiring, appraising, alpplying assesing
problems with ebm
lack of skills (literature searches, critical analysis)
time consuming
evidence may be lacking
rct results may not be generalizable
potential of abuse by health care purchasers
the first step in developing a research strategy is to
study previously published research literature
issues with complimentary research
interrater/inter examiner reliability funding blinding is an issue philosophical aspects (chi or subluxation) limited number of researchers available
what are included in clinical research process for a lets say drug to get from animals to humans
pre-clinical testing investigational new drug application (IND) phase 1, 2, 3 licensing approval post marketing studies
what is phase 1 for
assess safety
phase 2
test for effecetiveness
phase 3
large scale testing
what is used in pre clinical testing
animals
what part of clinical research process does chiro and accu not use
IND