Midterm Flashcards

1
Q

what is cognitive neuroscience

A

study of psychological processes and how they’re implanted in the brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

3 keys to conducting an fMRI study

A
  1. Design a behavioral task that isolates the psychological processes of interest in the brain
  2. Modify the behavioral task so that it’s suitable for an fMRI study
  3. Analyze the behavioral and fMRI data
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ethical considerations of studies

A

informed consent

debriefing (tell purpose of study at the end)

privacy/confidentiality

fraud (making up data)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Four goals of scientific research

A

Describe: observe a behavior, make a prediction

Predict

Determine causes

Explain mechanisms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

3 types of studies

A

descriptive: observational, notice patterns in the world and report them

correlative: notice a pattern a between two different variables and try to determine how they’re related

true experiments: random assignment, manipulate a variable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

within vs between subject design

A

between: groups receive different treatments

within: each subject receives all treatments (makes it harder for 3rd variable to affect results

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

within subjects design limitation

A

carry over effects: effects from one experimental condition carry over to the next

timing/order of treatments matter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

example of confounds

A

clever hans: cues from experimenters affected horse’s reaction

bigfoot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

congruency effect

A

reaction times are faster when the target and distractor are congruent than when they are incongruent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Congruency sequence effect

A

(aka conflict adaptation)

the congruency effect is smaller when the previous trial is incongruent than when congruent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which process drives the CSE?

A
  • Selection for action (botvinick)
    • shift attention toward the relevant target
  • Response inhibition (ridderinkhof)
    • inhibit the response engendered by the distractor
  • Learning and memory confounds (mayr)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

botvinick et al.

A

selection for action (previous theory): ACC focuses attention on stimuli we want to act upon

conflict monitoring (botvinick): ACC activated when conflict is detected, dorsolateral prefrontal cortex (DLPFC) activated, then attention is increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Mayr et al.

A
  • Mayr et al predicted:
    • CSE happens when target and flanker are repeated
    • No CSE when either target or flanker change
  • Found that conflict adaptation occurred only in repetition trials, contradicting the conflict monitoring model
  • CSE comes back when stimulus is repeated in n-2 to n
  • Reduced ACC activity on iI (vs cI) trials reflects repetition priming not conflict monitoring
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

selection for action (attention adaptation) triggered by:

A

perceptual expectation (expectations about what comes next)

conflict monitoring

negative affect (almost pressing wrong button makes you frustrated)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

cI vs iI trials in botvinick et al.

A

cI trials: higher conflict

iI: high selection for action

cI trials had greated ACC response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

learning and memory processes that may influence the CSE include:

A

feature repetitions (mayr et al.)

contingency learning biases (schmidt)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Mayr et al used what kind of task

A

2-AFC flanker task

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

to avoid feature repetitions, some researchers have…

A

employed tasks w/ larger stimulus sets (ex: ullsperger et al.)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

contingency learning confounds/biases

A

Ullsperger: 9-AFC (alternative forced choice)

with larger stimulus sets (to avoid feature repetitions), congruent and incongruent trials are presented equally, even though there are fewer unique congruent stimuli (shown 8x often)

flankers (ex 11 11) appeared w/ congruent target (ex 1) 50% of the time but w/ incongruent targets (22 22, etc.) only 6.25% of the time

lead to CSE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

describe both experiments in mayr et al.

A

experiment 1: standard flanker task, but analyzed trials by whether they were a change or repetition

experiment 2: removed repetition by alternating b/w up/down and left/right arrows

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what does AFC stand for

what do classic experiments use

mayr et al

ullsperger

A

alternative forced choice

classic: 2-AFC (left/right)
mayr: 4-AFC (right/left/up/down)
ullsperger: 9-AFC (9 possible responses)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

how does a contingency learning bias lead to a CSE

A

particpants want to respond fast/accurately, so learn strategy of making response congruent w/ flankers

after congruent trial (strategy worked!), contingency bias increases (faster RT cC trials, slower to cI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

mental rotation confounds

A

Kunde and Wuhr

observed a CSE in a 4-AFC, even in trials w/o exact feature repetition or contigency learning biases)

however, all arrow stimuli were mental rotations of the same arrow stimulus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Prime probe word task (Schmidt and Weissman)

A

avoided feature repetitions, contigency learning, and mental rotation confounds

  • 4-AFC task (left-right vs up-down)
  • Alternated b/w these two tasks every trial (no response repetitions)
  • Presented congruent/incongruent stimuli equally (no contigency learning)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
conclusion of schmidt and weissman
CSE can be observed independent of confounds a control process influences the CSE, but does not reveal which one: selection for action (aka attention adapation) or response inhibition
26
how does prime probe word task of in class experiment differ from schmidt and weissman?
increase time separating the prime (distractor) from the probe (target) from 33 ms to 800 ms
27
logic of class experiment (increasing time b/w distractor and target)
overall congruency effect should vanish however, subjects may still use their memory of what the previous trial was to predict what the next trial will be therefore, should observe a CSE even though there is no overall congruency effect
28
class experiment: selection for action (attention adaptation) theory
after an incongruent trial and w/ long time b/w distractor and target, subjects can shift all attention to the target when it appears if they shift all their attention to the target, there won't be any attention left to identify the distractor thus, there should be **no congruency effect after incongruent trials**
29
class experiment: response inhibition theory
w/ a long time b/w target and distractor, subject inhibit response signaled by the distractor after incongruent trials if they do, there should be a negative (reverse) congruency effect after incongruent trials (faster on iI than iC)
30
CSE graph label
31
p value
probability that null hypothesis is false null hypothesis = no significant difference b/w two groups
32
one tailed t test
test if sample mean is larger or smaller than population mean significant when the difference b/w means are large enough that it's unlikely to occur by chance 5% in one tail
33
two tailed t test
test if sample mean is larger or smaller than population mean 2.5% in each tail instead
34
paired (one-sample) t-test
two sample means come from the same subjects compare subjects to themselves
35
unpaired (two-sample) t-test
the two sample means come from different subjects
36
main effect
dependent variable changes based on the independent variable
37
interaction
the effect of one independent variable on the dependent variable varies based on another independent variable unparallel lines
38
simple effects
limit analysis to one of the independent variables to see the what is driving an interaction only calculated when an interaction is significant
39
clinical applications of fMRI example
pateints with traumatic brain injury (TBI) still had some brain activity when imaged with fMRI
40
basic science and fMRI: movies and brain activity
people shown movies while in fMRI reconstruct movie based on brain activity in the primary visual cortex
41
dogs and fMRI example
do dogs have similar brain activity as humans? using fMRI, found that area of reward in dogs correlates to same area in humans
42
first brain imaging experiment
Angelo Mosso humans lay on seesaw, thought that fi people think hard, blood would rush to head and tip the seesaw
43
Blood Oxygen Level Dependent (BOLD) signal
an *indirect* measure of neural activity increased neural activity → increased blood flow → flow of oxygenated blood (oxy/deoxyhemoglobin ratio increases) → increased BOLD signal
44
typical BOLD signal looks like what
initial undershoot: due to neural area using up oxygen before getting more oxy blood oxy/deoxy ratio increases oxy/deoxy ratio goes below baseline (use up oxy blood)
45
what does conducting an fMRI study involve
put subject in scanner have subjects perform cognitive tasks record the BOLD signal
46
how is BOLD signal recorded
multiple horizontal slices taken, then divided into many small cubes (voxels) high spatial resolution
47
TR
time it takes to get a whole set of slides
48
cognitive subtraction
2 conditions only differ in one respect, parts of brain that are more active is due to that difference
49
assumption of pure insertion
assumption for cognitive subtraction adding new component to a task doesn't change the basic processes that were already in the task (can add w/o changing pre-existing processes)
50
interpreting the bold signal
increased bold signal does not mean more neurons are firing means more metabolic activity is occuring, but could be excitatory or inhibitory activity
51
fMRI vs normal MRI
MRI (structural MRI): used to study brain anatomy fMRI (functional): used to study brain function
52
how does structural MRI work
normally: magnetic fields of proteins initially random in scanner: some protons align radio wave pulse: orients protons and produces signal eventually protons relax back to original orientation
53
diffusion tensor imaging (DTI)
MRI based method for imaging the axon tracts that form the white matter of the brain DTI measures density and motion of water that travels along myelin-covered axons water normally diffuses in all directions (**isotropic**), but diffusion along myelinated axon is limited (**anisotropic**), so water moves only along length of axon bc myelin creastes lipid boundary that influences water movement
54
sports and head injury research
concussions associated w/ chronic traumatic encephalopathy (CTE) tau protein builds up in brain problems w/ memory, concentration, depression
55
3 main parts of the brain
neocortex, limbic, brainstem/cerebellum
56
Layer 1 of the brain
**brain stem**: breathing, swallowing, bladder, HR **cerebellum**: balance, coordination
57
Layer 2: limbic system
**amygdala:** emotion **hippocampus:** memory **cingulate gyrus/cortex:** conflict, emotion, pain
58
layer 3: neocortex
**parietal lobe**: touch **frontal lobe**: higher order thinking, planning, decisions **temporal lobe**: hearing, memory **occipital lobe:** vision
59
anatomical directions
**rostal**: toward nose **caudal**: back of head **ventral**: bottom **dorsal**: top
60
parts of cingulate cortex
61
Parvizi et al.
found that the anterior midcingulate cortex (aMCC) plays an important role eliciting determination and motivation within an individual to face challenges
62
Coleshill et al.
studied unilateral hippocampal electrical stimulation in epilepsy patients; found that that stimulation of the left hippocampus produced recognition memory deficits for words, while right hemisphere was associated with face recognition deficits
63
longer neural signal leads to _____ BOLD response
taller *and* longer BOLD response
64
superposition
fundamental basis for block design individual responses summate to yield a large response → large BOLD response
65
how long is ideal for a block
10-20 seconds allows enough time for the BOLD signal to go back to baseline so we can actually see signal
66
pros of block vs event related design
block: easier to see overall signal event related: easier to see shape per trial
67
block design graph: why is there a dip
undershoots slightly from initial trials signal from initial trials go back to baseline and drag the sum signal down
68
owen et al.
infer cognitive function in vegetative state had patients/controls imagine tennis, then imagine navigation (of living room) tennis and navigation produce different patterns of activity, and patients and controls had similar activation for both tasks
69
faces vs houses experiment
**fusiform face area** (FFA) activated more for faces than houses **parahippocampal place area** (PPA) activated more for houses than faces
70
problems of longer blocks
1. sagging caused by undershoots summing together (dip in graph) 2. lots of noise at low frequences of stimulation, therefore we want a higher frequency (shorter blocks so that noise is a diff frequency than signal)
71
houses and faces experiment: what does alternating showing houses and faces do
prevent practice/habituation effects resulting signal reveals main differences in activity b/w block types maximizes ability to detect differences in activity at the expense of detecting absolute activity
72
what if we wanted to detect absolute activity with block design?
include low-level baseline condition (fixation) b/w our two block types of interest signal reveals activity for each block type and differences in activty b/w the two block types
73
pros and cons of block designs
**pros**: big signals (summed activation), large signal relative to noise is easier to detect **cons**: if subject makes mistake, hard to get rid of just one trial, cant separate activity (male faces vs female faces)
74
slow event related designs
present 1 trial every 16-20 seconds to isolate BOLD signal to each stimulus/trial
75
cued stroop task
double dissociation: ACC activated when there is conflict/incongruent DLPFC activated more by attention (ink color)
76
why would you want to go faster with event-related designs?
subjects get bored
77
linearity assumption
if things add up, you can go faster if not, BOLD responses differ depending on whether going fast or slow degree of sub-linearity referred to as a "**refractory effect**"
78
2 design types of event-related design: rapid unjittered
randomized trial order, spacing b/w trials is consistent can see difference b/w conditions, but not how much it changes relative to baseline since baseline isn't measured
79
2 design types of event-related design: rapid jittered
vary spacing between trials to get more baseline activity measurements
80
wagner et al.: recognition memory
* participants saw 80 word trials in **rapid jittered design** * fixation trials added to create jitter * asked if word is abstract or concrete, then did recognition test late * results: they could predict which words subjects would remember (words w/ more activity)
81
functional connectivity
if activity in two regions is correlated across time, then these regions may be communicating
82
functional connectivity: flanker/ stroop tasks
more connectivity b/w ACC and DLPFC in incongruent trials than congruent trials
83
preprocessing of fMRI data
gets rid of variability in bold signal that is not due to the task
84
5 parts of preprocessing
slice-timing realignment coregistration normalization smoothing
85
slice timing: different way of collected slices in each TR?
- interleaved: all odd or even slices taken first - ascending (1,2,3,4,....): start at bottom of brain - descending (24,23,22,...): start at top of brain
86
slice timing: SPM assumes...
each scan is instantaneous
87
green curve: comes from slice collected latest because it is farther along in the BOLD signal sooner than the blue curve
88
slice timing correction
since later slices are shifted left, need to shift slices **right** to align everything with first slice
89
slice timing only needed if
temporal dynapics of BOLD responses are important (event-related designs) if TR is small enough (\< 3 seconds)
90
realignment
* correct for motion of participants’ head during the scan
91
different types of motion
pitch, roll yaw
92
normalization
* stretch and warp each participant’s brain to match a template brain
93
smoothing
replace the intensity value of a voxel w/ a weighted average of its original value plus the neighboring voxels
94
why do we smooth
to increase signal to noise ratio to increase chance of seeing common activation b/w subjects