Midterm Flashcards
The skin is divided into what two layers?
-The dermis and epidermis
What is just deep to the dermis and allows it to move freely over internal organs?
-The hypodermiS
What are the layers of the epidermis from deep to superficial?
-Basale, Spinosum, Granulosum, lucidum, corneum
What layer of the epidermis houses active keratinocytes?
-The Stratum Basale
Which layer of the epidermis helps the skin withstand friction and shear force?
-Stratum Spinosum
What layer of the epidermis helps the skin prevent water loss?
-The stratum Granulosum
What is contained in the stratum granulosum that prevents water loss?
-Intercellular space comprised of lipid rich material
What layer of the epidermis provides protection from the environment?
-Stratum lucidum
In what areas of the body in the stratum lucidum visible?
-The palms and bottoms of feet
What layer of the epidermis do keratinocytes become corneocytes?
-The stratum Conreum
What layer of the epidermis forms an acid mantle to make the skin more resistant to infection?
-The stratum corneum
Where are melanocytes located?
-Between the straum basale and the stratum spinosum
What type of cells are located in the stratum spinosum and provide an immune response?
-Langerhan cells
What type of cells are located in the stratum basale and detect light touch and tactile sensation?
-Merkel cells
Where does blood flow run in the dermis?
-Just deep to the basement membrane, to be able to supply the epidermis; allowing nutrition to the active keratinocytes
What are the name of the shunts of blood flow that run through the dermis?
-ateriovenous anastmoses
what does the dermis contain to help carry out excess fluid?
-lymphocytes
Where do nerve running through the dermis become free nerve endings?
-Just before the epidermal junction
What is the more superficial layer of the dermis?
-The papillary dermis
What do fibroblasts in the papillary dermis create?
-Elastin and type I collagen
The collagen and elastin made in the papillary dermis are responsible for giving what characteristics to skin?
-Turgor and toughness
What do the firbroblasts in the papillary dermis create that helps aid wound closure?
-Hyaluronic acid
What is the deep layer of the dermis that is located over the subcutaneous fat?
-The reticular Dermis
What is found in the reticular dermis that detects light touch and vibration
-Meisner’s Corspuscle
What is the term for skin loss only on the epidermis?
-Erosion
What type of wounds are erosion wounds?
-1st degree burns and pressure sores
Partial thickness wounds involved what layers?
-The epidermis and papillary dermis (demonstrate bleeding)
What type of wounds are partial thickness wounds?
-2nd degree burns and pressure sores
What wounds involve the dermis, epidermis and hypodermis?
-Full thickness wounds
What is the first phase of skin healing?
-Hemostasis
How long does hemostasis last?
-less than 1 hour
What is hemostasis directed by?
-platelet aggregation
What occurs during hemostasis?
-The wound stops bleeding and scab begins to form
Clinical signs of hemostasis are similar to the inflammation stage, but what is the factor that distinguishes between the two?
-clot formatoin
What is the inflammation stage of wound healing also known as?
-scavenger or neogenesis
What does the inflammation stage of wound care mainly invole?
-cleaning the wound
What begins immediately after the injury to get rid of necrotic tissue?
-autolytic dedridement
What does the proliferation stage of wound healing entail?
-injured tissue being replaced by healthy cells undergoing mitosis
What is needed to provide nutrients to the wound and remove waste and deris?
-Angiogenesis
What is granulation tisse characterized by?
-Beefy Red appearance
What is the final stage of wound healing that begins after wound closure?
-Maturation/remodeling phase
What occurs in the maturation stage?
-A aggregation of cells that increases the strength of the wound
When a wound heals, how much strength does it retain from the original skin?
-80%
What is the term for the recurrence of wounds in the same area due to the decreased in tensile strength?
-Recidivism
What are the 3 classifications of wound response?
- Healing by primary intenetion
- Healing by delayed primary intention
- Healing by secondary intention
What type of healing will you typically see after surgury?
-primary intention (miminal scaring)
What is the example of a wound healing by primary intention?
-Those that have been surgically closed and are free from bacteria or pathogens
Wounds the heal by primary intention typically heal by when?
-2 weeks
What are wounds healing by delayed primary intention characterized by?
-wounds that have some sort of problem on the inside that prevent the edges from approximating; can be debris
What can result due to a delayed primary intention wound?
-A granuloma
How do delayed primary intention wounds normally resolve?
-Surgically
What is the usual wound healing process for non-surgical wounds?
-Secondary intention (progress through all wound stages)
Wounds seen in the clinic will be what two types of wounds?
-Delayed primary intention or sedondary
Cells communicate in the matrix to provide a better environment for what?
-wound healing
What breaks up the wound matrix to enhance the surrounding wound bed allowing for epithelial migration?
-Plasminogen activators and Mixed metalloproteinases (MMPs)
The majority of the drainage that leaves wounds consists of what?
-Proteins
What is the ECM of the skin comprised of?
-Collagen, elastin, proteoglycans and GAGs
What type of wounds occur with inadequate healing and may take months or years to close?
-Chronic wounds
What do chronic wounds typically occur because of?
- Foreign debris
- bacterial disruptions
- disease processes (circulatory disorders)
What are the most common chronic wounds?
-Venous insufficiency wounds
What 7 factors can impead healing?
-Infection, medications, comobities, cancer/radiation, autoimmune disorders, stress, lack of sleep
What can be applied to wounds that are being delayed by infection?
-antimicrobials
Fungal infections most commonly occur where?
-in moist environments under dressings
How can corticosteroids delay wound healing?
- allows for a lag time for inflammatory cells and fibroblasts to occupy the area
What can be given to those with prolonged steroid use the allow for better wound healing?
-ZMAC (zinc, magnesium, Vitamin A, Vitamin C)
What effects to NSAIDs have on wound healing?
-Decrease platelet aggregation, decrease tensile strength, and decrease granulation formation during the proliferation stage
How does diabetes delay wound healing?
-it increase glucose levels and impairs leukocyte function
How does arterial insufficiency delay wound healing?
-limits the ability to remove waste and provide nutrients
What is a large indicator of wound healing?
-cardiac function
What type of cells are particularly effected by ionizing radiation therapy and causes decreased tensile strength of the tissue and delayed healing?
-Fibroblasts
Why does chemotherapy cause poor wound healing?
-it kills good wound healing cells as well as cancer cells
What cancer treatment can cause decrease blood flow and sensation to the extremites and may lead to further tissue degeneration?
-CIPN
What cancer treatment may cause nutrional deficits and cause poor healing?
-Chemoside
Stress causes the release of what that will impair the response to injury?
-epi and norepi
How does smoking impair healing?
-it causes vasoconstriction and decreases the healing response
What can lead to insulin resistance and high glucose levels that can inhibit healing in all phases?
-alcohol consumption
What is the normal what blood cell count?
-4.5-11
What may lead to increased WBC count?
-infection or trauma
What does a low WBC count mean?
-decrease immune response to bacteria
What is the normal levels of hemoglobin?
-12-18 g/dL
Increased of decrease levels of hemoglobin will cause what?
-The inability of the wound to progress
What is the normal level of hematocrit?
-36-50%
What is increased hematocrit a sign of?
-thrombi/emboli
What is normal prothrombin time?
-2.5 seconds
What does increased prothrombin time cause?
-easy bleeding
What does decrease prothrombin time cuase?
-increased clotting
What is the normal HbA1C range?
-less than or equal to 5.7 percent
increase HbA1C will cause what?
-Delayed wound healing
What is the average glucose levels?
-less than 100 mg/dL
What dictates the type of wound healing?
-Tissue loss
What is the name for the Red Yellow and Black Classification system?
-Marion Lab Scale
What is the Marion Lab scale used to describe?
-the wound surface that correlates with the specific therapy needs
What are Red wounds described to be?
-Healthy, cleaning, healing and granulating
What is a yellow wound indicative of?
-A possible infection, or presense of necrotic tissue
What are black wounds characterized as?
-Necrotic or dead
What is the most widely known wound classification system used for pressure ulcers?
-National Pressure Ulcer Advisory Panel Pressure Ulcer Staging System
What does the NPUAP used to describe?
-The severity of the wound in order to dictate treatment protocols for reimbursement with regard to treatment products
What is the wagner scale used to classify?
-ulcers
What was the wagner scale originally used to diagnose and treat?
-the dysvascular foot
How does the wagnar scale describe a wound?
-The depth of the injury and presence of infection on a 0-6 scale
What is a grade 0 ulcer on the wagner scale?
-A pre or postulcerative site
How is a grade 1 ulcer on the wagner scale described?
-Superficial wounds through the epidermis or also the dermis, but no subcutaneous involvement
How is a grade 2 ulcer on the wagner scale desribed?
-penetrates through then tendon and capsule but the done and joint is not effected; full thickness wound
What is a grade 3 ulcer on the wagner scale?
-ulcer that affects joint and bone with abscess or osteomyelitis
What is a grade 4 on the wagner scale?
-forefoot gangrene within a digit
What is a grade 5 on the wagnar scale?
-Whole foot gangrene, requires amputation proximal to the digit
What is the University Texas system used to classify?
-Diabetic foot ulcers when a diabetic nephropathy is present
What 4 things does the UT scale grade?
-(A) wound depth; (B) infection, (C) Ischemia, (D) infection
What is step 1 in the wound care process?
-General assessment (regular PT exam)
What is step 2 in the wound care process?
-Diagnosis
What is step 3 of the wound care process?
-Prognosis and goal
What is step 4 of the wound care process?
-Re-evaluation
What things are important to ask the patient regarding a wound?
-onset, appearance, signs and symptoms, medication, and psycho-social history
What is part A of the diagnosis proccess of wound assessment?
-an in depth examination of testing for related factors and co-morbities, and focused wound examination