Midterm Flashcards
1
Q
Tetrodoxin (TTX)
A
- blocks Na+ channels
- highly toxic, lethal
- blocks APs
2
Q
Bromocriptine
A
- DA D2
- full agonist
- antiparkinsonian
3
Q
9-THC
A
- CB1 AN
- full agonist
4
Q
Morphine
A
- μ opiate
- full agonist
5
Q
Nicotine
A
- nicotinic ACh
- full agonist
6
Q
Varenicline (Chantix)
A
- nicotinic ACh
- partial agonist
- smoking cessation
7
Q
Haloperidol
A
- DA D2 competitive antagonist
- antipsychotic
8
Q
Clozapine
A
- DA competitive antagonist
- antipsychotic
9
Q
Propranolol (Inderal)
A
- β adrenergic competitive antagonist
- treat high bp
10
Q
Scopolamine
A
- muscarinic (ACh) competitive antagonist
- antiparkinsonian
- high doses - hallucinogenic
11
Q
Atropine
A
- muscarinic (ACh) competitive antagonist
- antiparkinsonian
- high doses - hallucinogenic
12
Q
FG7142
A
- benzodiazepine site
- inverse agonist/negative allosteric modulator
- opposite effects of benzodiazepines
13
Q
Rimonabant
A
- CB1 inverse agonist
- appetite suppressant
14
Q
Pimavanserin
A
- 5-HT2A inverse agonist
- treat hallucinations in PD
15
Q
Picrotoxin
A
- GABAA noncompetitive antagonist
16
Q
Valium
A
- positive allosteric modulator
- facilitates GABAA receptor function
- antianxiety agent and anticonvulsant
17
Q
Alpha-Methyl Tyrosine
A
- blocks CA synthesis by inhibiting TH (rate limiting step)
18
Q
Alpha-Methyl DOPA (Aldomet)
A
- blocks CA synthesis because it is a substrate for the LAAD enzyme, leading to the synthesis of ‘fake transmitters’
- treatment for high bp
19
Q
L-DOPA
A
- precursor
- increases CA synthesis (especially DA)
- treat PD
20
Q
Tyrosine
A
- not effective as a medication, although a precursor
- under normal nutritional conditions the enzyme TH is saturated, so additional tyrosine will not increase the reaction time
21
Q
Reserpine
A
- block storage of MA and deplete MA
- VMAT 1&2 (aka inhibit VMAT)
- decreases 3-MT, increases DOPAC & HVA
- antipsychotic
- can produce parkinsonianism and depression
22
Q
Tetrabenazine
A
- block storage of MA and deplete MA
- VMAT-2 (aka inhibit VMAT)
- can produce parkinsonianism and depression
- analogs used for imaging DA terminals
23
Q
Amphetamine
A
- dexedrine, benzedrine, methedrine
- stimulate release of MA
- treat ADHD
- major stimulant
- Ca independent
- CA uptake inhibitor
- affects 5-HT uptake at higher doses
24
Q
Methylphenidate (Ritalin)
A
- stimulate CA release
- major stimulant
- treat ADHD
- Ca independent
- CA uptake inhibitor
25
Phenylephrine
- α agonist
26
Clonidine
- α2 agonist
27
Phentolamine
- α antagonist
28
Yohimbine
- α2 antagonist
29
Isoproternol
- β agonist
30
Tropolone
- COMT inhibitor
| - inhibit CA metabolism
31
Phenelzine (Nardil)
- MAO inhibitor, nonspecific
| - inhibit CA metabolism
32
Moclobemide
- MAO-A inhibitor (NE)
| - inhibit CA metabolism
33
Deprenyl
- MAO-B inhibitor (DA)
- inhibits CA metabolism
- low doses - affects DA more; high doses - affects 5-HT
- antiparkinsonian drug
34
Cocaine
- CA uptake inhibitor
| - affects 5-HT uptake
35
GBR 12909
- DA uptake inhibitor
36
Bupropion (Welbutrin, Zyban)
- DA/NE uptake inhibitor
37
Desipramine
- NE uptake inhibitor
38
PCPA
- inhibits TrypH, blocks 5-HT synthesis
39
P-Chloroamphetamine
- potent at release of 5-HT
40
Mianserin
- 5-HT2 family antagonist
41
Clozapine
- atypical antispsychotic
| - block muscarinic receptors
42
Risperidol
- atypical antipsychotic
| - block muscarinic receptors
