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Neuropsychopharmacology > Midterm > Flashcards

Midterm Flashcards

1
Q

Tetrodoxin (TTX)

A
  • blocks Na+ channels
  • highly toxic, lethal
  • blocks APs
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2
Q

Bromocriptine

A
  • DA D2
  • full agonist
  • antiparkinsonian
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3
Q

9-THC

A
  • CB1 AN

- full agonist

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4
Q

Morphine

A
  • μ opiate

- full agonist

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5
Q

Nicotine

A
  • nicotinic ACh

- full agonist

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6
Q

Varenicline (Chantix)

A
  • nicotinic ACh
  • partial agonist
  • smoking cessation
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7
Q

Haloperidol

A
  • DA D2 competitive antagonist

- antipsychotic

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8
Q

Clozapine

A
  • DA competitive antagonist

- antipsychotic

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9
Q

Propranolol (Inderal)

A
  • β adrenergic competitive antagonist

- treat high bp

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10
Q

Scopolamine

A
  • muscarinic (ACh) competitive antagonist
  • antiparkinsonian
  • high doses - hallucinogenic
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11
Q

Atropine

A
  • muscarinic (ACh) competitive antagonist
  • antiparkinsonian
  • high doses - hallucinogenic
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12
Q

FG7142

A
  • benzodiazepine site
  • inverse agonist/negative allosteric modulator
  • opposite effects of benzodiazepines
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13
Q

Rimonabant

A
  • CB1 inverse agonist

- appetite suppressant

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14
Q

Pimavanserin

A
  • 5-HT2A inverse agonist

- treat hallucinations in PD

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15
Q

Picrotoxin

A
  • GABAA noncompetitive antagonist
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16
Q

Valium

A
  • positive allosteric modulator
  • facilitates GABAA receptor function
  • antianxiety agent and anticonvulsant
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17
Q

Alpha-Methyl Tyrosine

A
  • blocks CA synthesis by inhibiting TH (rate limiting step)
18
Q

Alpha-Methyl DOPA (Aldomet)

A
  • blocks CA synthesis because it is a substrate for the LAAD enzyme, leading to the synthesis of ‘fake transmitters’
  • treatment for high bp
19
Q

L-DOPA

A
  • precursor
  • increases CA synthesis (especially DA)
  • treat PD
20
Q

Tyrosine

A
  • not effective as a medication, although a precursor
  • under normal nutritional conditions the enzyme TH is saturated, so additional tyrosine will not increase the reaction time
21
Q

Reserpine

A
  • block storage of MA and deplete MA
  • VMAT 1&2 (aka inhibit VMAT)
  • decreases 3-MT, increases DOPAC & HVA
  • antipsychotic
  • can produce parkinsonianism and depression
22
Q

Tetrabenazine

A
  • block storage of MA and deplete MA
  • VMAT-2 (aka inhibit VMAT)
  • can produce parkinsonianism and depression
  • analogs used for imaging DA terminals
23
Q

Amphetamine

A
  • dexedrine, benzedrine, methedrine
  • stimulate release of MA
  • treat ADHD
  • major stimulant
  • Ca independent
  • CA uptake inhibitor
  • affects 5-HT uptake at higher doses
24
Q

Methylphenidate (Ritalin)

A
  • stimulate CA release
  • major stimulant
  • treat ADHD
  • Ca independent
  • CA uptake inhibitor
25
Q

Phenylephrine

A
  • α agonist
26
Q

Clonidine

A
  • α2 agonist
27
Q

Phentolamine

A
  • α antagonist
28
Q

Yohimbine

A
  • α2 antagonist
29
Q

Isoproternol

A
  • β agonist
30
Q

Tropolone

A
  • COMT inhibitor

- inhibit CA metabolism

31
Q

Phenelzine (Nardil)

A
  • MAO inhibitor, nonspecific

- inhibit CA metabolism

32
Q

Moclobemide

A
  • MAO-A inhibitor (NE)

- inhibit CA metabolism

33
Q

Deprenyl

A
  • MAO-B inhibitor (DA)
  • inhibits CA metabolism
  • low doses - affects DA more; high doses - affects 5-HT
  • antiparkinsonian drug
34
Q

Cocaine

A
  • CA uptake inhibitor

- affects 5-HT uptake

35
Q

GBR 12909

A
  • DA uptake inhibitor
36
Q

Bupropion (Welbutrin, Zyban)

A
  • DA/NE uptake inhibitor
37
Q

Desipramine

A
  • NE uptake inhibitor
38
Q

PCPA

A
  • inhibits TrypH, blocks 5-HT synthesis
39
Q

P-Chloroamphetamine

A
  • potent at release of 5-HT
40
Q

Mianserin

A
  • 5-HT2 family antagonist
41
Q

Clozapine

A
  • atypical antispsychotic

- block muscarinic receptors

42
Q

Risperidol

A
  • atypical antipsychotic

- block muscarinic receptors

Neuropsychopharmacology (1 decks)

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