Midterm Flashcards
Tetrodoxin (TTX)
- blocks Na+ channels
- highly toxic, lethal
- blocks APs
Bromocriptine
- DA D2
- full agonist
- antiparkinsonian
9-THC
- CB1 AN
- full agonist
Morphine
- μ opiate
- full agonist
Nicotine
- nicotinic ACh
- full agonist
Varenicline (Chantix)
- nicotinic ACh
- partial agonist
- smoking cessation
Haloperidol
- DA D2 competitive antagonist
- antipsychotic
Clozapine
- DA competitive antagonist
- antipsychotic
Propranolol (Inderal)
- β adrenergic competitive antagonist
- treat high bp
Scopolamine
- muscarinic (ACh) competitive antagonist
- antiparkinsonian
- high doses - hallucinogenic
Atropine
- muscarinic (ACh) competitive antagonist
- antiparkinsonian
- high doses - hallucinogenic
FG7142
- benzodiazepine site
- inverse agonist/negative allosteric modulator
- opposite effects of benzodiazepines
Rimonabant
- CB1 inverse agonist
- appetite suppressant
Pimavanserin
- 5-HT2A inverse agonist
- treat hallucinations in PD
Picrotoxin
- GABAA noncompetitive antagonist
Valium
- positive allosteric modulator
- facilitates GABAA receptor function
- antianxiety agent and anticonvulsant
Alpha-Methyl Tyrosine
- blocks CA synthesis by inhibiting TH (rate limiting step)
Alpha-Methyl DOPA (Aldomet)
- blocks CA synthesis because it is a substrate for the LAAD enzyme, leading to the synthesis of ‘fake transmitters’
- treatment for high bp
L-DOPA
- precursor
- increases CA synthesis (especially DA)
- treat PD
Tyrosine
- not effective as a medication, although a precursor
- under normal nutritional conditions the enzyme TH is saturated, so additional tyrosine will not increase the reaction time
Reserpine
- block storage of MA and deplete MA
- VMAT 1&2 (aka inhibit VMAT)
- decreases 3-MT, increases DOPAC & HVA
- antipsychotic
- can produce parkinsonianism and depression
Tetrabenazine
- block storage of MA and deplete MA
- VMAT-2 (aka inhibit VMAT)
- can produce parkinsonianism and depression
- analogs used for imaging DA terminals
Amphetamine
- dexedrine, benzedrine, methedrine
- stimulate release of MA
- treat ADHD
- major stimulant
- Ca independent
- CA uptake inhibitor
- affects 5-HT uptake at higher doses
Methylphenidate (Ritalin)
- stimulate CA release
- major stimulant
- treat ADHD
- Ca independent
- CA uptake inhibitor
Phenylephrine
- α agonist
Clonidine
- α2 agonist
Phentolamine
- α antagonist
Yohimbine
- α2 antagonist
Isoproternol
- β agonist
Tropolone
- COMT inhibitor
- inhibit CA metabolism
Phenelzine (Nardil)
- MAO inhibitor, nonspecific
- inhibit CA metabolism
Moclobemide
- MAO-A inhibitor (NE)
- inhibit CA metabolism
Deprenyl
- MAO-B inhibitor (DA)
- inhibits CA metabolism
- low doses - affects DA more; high doses - affects 5-HT
- antiparkinsonian drug
Cocaine
- CA uptake inhibitor
- affects 5-HT uptake
GBR 12909
- DA uptake inhibitor
Bupropion (Welbutrin, Zyban)
- DA/NE uptake inhibitor
Desipramine
- NE uptake inhibitor
PCPA
- inhibits TrypH, blocks 5-HT synthesis
P-Chloroamphetamine
- potent at release of 5-HT
Mianserin
- 5-HT2 family antagonist
Clozapine
- atypical antispsychotic
- block muscarinic receptors
Risperidol
- atypical antipsychotic
- block muscarinic receptors
