Midterm Flashcards
Human Chorionic Gonadotropin (hCG)
- Secreted into maternal circulation after implantation (5-7 days after fertilization)
- Doubles every 29-53 hours (or 2-3 days) for 30 days after implantation
- Serial hCG testing every 3 days
- Not useful in determining gestational age
- Urine test becomes positive around missed menses
- Serum test becomes positive around 9 days after conception (more sensitive; quantitative or qualitative)
Basic lab tests done during pregnancy
- hCG
- US
Lab tests done during the initial obstetrical visit
(around 10 weeks, ideally)
- CBC
- ABO-rh
- Ab screen
- Rubella
- Syphilis
- Hep B
Lab tests done for at-risk pregnancies
- HIV
- Varicella
- Thyroid
- DM
- others if symptomatic
Lab tests done at standard obstetrical visits
- Urine chemistry at every visit
- Glucose screening, CBC, and Ab screen at 24-28 weeks
- CBC, Ab screen, and GBS probe at 36 weeks
When/how pregnancy can be diagnosed
- Serum hCG after implantation, about 9 days after conception
- Urine hCG after first missed menses
- TVUS at 5-6 weeks
- Transabdominal US at 7-8 weeks
- Fetal heart tones at 10-13 weeks
Indications for US in pregnancy
- Irregular menses
- Unknown LMP
- Patients who conceive while on hormonal contraception
- When physical findings differ from EDD based on LMP
Naegle’s Rule
- To calculate EDD
- LMP minus 3 months plus 7 days
> LMP = 6/16
> 6/16 - 3 months = 3/16 + 7 days = 3/23
> EDD = 3/23
Why is an accurate due date important?
- To know what medications are safe and appropriate
- To determine if the fetus is growing appropriately
- To determine eligibility for an out-of-hospital birth (don’t want to deliver a preemie at home)
- To determine IUGR (intrauterine growth restriction)
- To determine the appropriate timing for tests and procedures
> TAB
> Amniocentesis
> 1st or 2nd trimester genetic tests (Down’s or chromosomal testing)
DDx for early bleeding
- Not always pathological; most often maternal source
- Spontaneous abortion/miscarriage
- Ectopic pregnancy (most serious to r/o)
- Placental bleeding/abruption/hematoma
- Trophoblastic disease
- Vaginitis, cervicitis, trauma, cancer, warts, polyps, fibroids
- Cervical ectropion
- Physiologic or implantation bleeding
Nausea and vomiting - mechanism
- B-hCG slows peristalsis
- Progesterone slows peristalsis and decreases HCl in stomach
- N/V contribute to placental growth b/c low energy intake stimulates placental growth in early pregnancy
Nausea and vomiting - diet treatment
- Dry crackers before getting out of bed
- Foods high in B vitamins (kale, brewer’s yeast, blackstrap molasses, wheat germ)
- Light protein snack at bedtime
- Small frequent meals every 1-2 hours; avoid full stomach
- Eat easily digested foods
- Fluids are better between meals to avoid diluting HCl
- Avoid food sensitivities
- Almonds
- Yogurt or kefir with added cinnamon
- Barley or oat broth
- Hard candies
- 1 tsp apple cider vinegar with 8oz warm water - first thing in the morning or with meals
Nausea and vomiting - lifestyle treatment
- Not opening eyes before getting out of bed
- Fresh air
Nausea and vomiting - botanical treatment
- Zingiber (ginger)
- Dioscorea villosa (wild yam)
- Tea of raspberry leaf, peppermint, black horehound, catnip, and/or meadowsweet
- Cardamom
- Umboshi paste
Nausea and vomiting - supplment treatments
- Vitamin B6
- Vitamin K
- Vitamin C
Nausea and vomiting - other treatments
- Homeopathy
- Acupuncture/acupressure
- Reflexology
- Hypnosis
Hyperemesis gravidarum - mechanism
- Hormonal changes
- Psychological and social stresses
- Thyroid issues
Hyperemesis gravidarum - treatment
- Homeopathy
- Drainage
- Counseling
- Liver and support (silybum)
- Acupuncture
Heartburn - mechanism
- Progesterone relaxes the cardiac sphincter
- Progesterone decreases gastric motility (including esophageal peristalsis)
- Stomach is displaced up and to the right
- Increased intragastric pressure and decreased intraesophageal pressure
Heartburn - treatment
- Relaxed meals eaten slowly and chewed fully
- Avoid trigger foods (coffee, chocolate, alcohol, fats)
- Avoid cold foods and drinks, carbonated drinks, processed foods, sugar, and cigarettes
- Pat of butter at start of meal
- Increase raw foods
- 1 Tbsp apple cider vinegar 3 hrs after eating
- Good posture, wear loose-fitting clothing
- Raw almonds, yogurt, dry popcorn
- Papaya or digestive enzymes, liquid calcium magnesium
- Antacids, antisecretory antihistamines
Dyspepsia, flatulence, eructations - diet treatments
- Consume 4+ fruits and vegetables/day, steamed instead of boiled
- Avoid gas-forming foods
- Avoid carbs and proteins in same meal
- Yogurt, kefir, probiotics
Dyspepsia, flatulence, eructations - lifestyle treatments
- Exercise
- Abdominal massage