Midterm Flashcards

0
Q

Imatinib mechanism of action

A

Inhibit BCR-Abl tyrosine kinase in Philadelphia chromosome positive cancer cells

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1
Q

What do cytostatic cancer drugs do?

A

Target mechanisms involved in growth of cancer cells- as opposed to cytotoxic drugs, which randomly kill all cells.

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2
Q

Under what conditions are a hematopoietic cell transplant made?

A
  1. Recovery requires new marrow/ immune cells

2. Chemo/radiation treatment will destroy the marrow

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3
Q

Sources of hematopoietic stem cells for transplantation

A
  1. Self

2. HLA (human leukocyte antigen) matched donor- twin, relative, other

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4
Q

Types of stem cell transplant conditioning therapy

A
  1. Myeloablative- destroys stem cells

2. Nonmyeloablative- doesn’t kill stem cells

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5
Q

Treatment goals before chemotherapy

A
  1. Reduce infection risk- perio
  2. Stabilize dentition, function
  3. Eliminate trauma, irritation
  4. Reduce bleeding risk
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6
Q

Concerns in treating patients who are undergoing chemo

A
  1. Bleeding problems
  2. Infection control
  3. Wound healing
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7
Q

Preventing spread of infection in chemo patients

A
  1. Prophylactic antibiotics
  2. Dental treatment
    - slow speed hand piece
    - rubber dam
    - high power suction
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8
Q

Precaution against bleeding problems in chemo patients

A

Administer platelets, coagulation agents

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9
Q

Sites most susceptible to oral mucositis

A

Non keratinized mucosa:

  • labial
  • buccal
  • lateral, ventral tongue
  • soft palate, oropharynx
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10
Q

Prevention of oral mucositis

A

Cryotherapy
Palifermin
Low energy laser

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11
Q

Basic care of oral mucositis

A

Bland rinses
Oral hygiene
Prophylactic antifungal and antiviral

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12
Q

Symptom management for oral mucositis

A

Topical anesthetics
Coating agents
Systemic analgesics

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13
Q

Causes of salivary gland dysfunction in cancer patients

A

Radiation
Chemo
Anti cholinergic medications

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14
Q

Dental developmental abnormalities associated with cancer

A
  • agenesis of teeth

- microdontia

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15
Q

Most common causes of renal failure

A

Diabetes
Hypertension
Chronic glomuleronephritis

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16
Q

Signs of uremia

A
Nausea
Vomiting
Headache
Vertigo
Visual changes
Seizures 
Azotemic breath
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17
Q

Electrolyte disturbances in renal failure

A

Metabolic acidosis
Hyperkalemia
PO4+
NA+

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18
Q

Renal failure- cardiovascular disease connection

A

Fluid buildup
Pulmonary edema
Hypertension

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19
Q

Blood disorders and renal failure

A

Anemia- decreased erythropoietin production

Coagulopathy- anticoagulant medication

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20
Q

How does renal failure lead to osteodystrophy?

A

Increased PO4++ retention leads to hyperparathyroidism, causing increased serum ca++, resorted from bone

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21
Q

Three conditions found in osteodystrophy in renal failure patients

A

Osteomalacia
Osteosclerosis
Osteitis fibrosa

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22
Q

Conservative renal failure management

A

Control fluid intake
Remove parathyroid
Medications
Limit protein intake

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23
Q

Two types of dialysis

A

Peritoneal- fluid placed in perotineal cavity to draw toxins, then drained.
Hemodialysis- blood is removed, filtered, and returned

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24
Explain an artervenous fistula for hemodialysis
A large vein and artery are joined to make a larger vessel that can withstand the high pressure and repeated punctures required for hemodialysis
25
Explain a cannula for hemodialysis
Like an external shunt placed in a blood vessel. Left closed for blood flow normally, the opened for access during hemodialysis
26
Symptoms of renal disease patients
Osteomalacia Carotenemia Uremic frost on oral tissues
27
Medical concerns for kidney patients
Avoid nephrotoxic drugs or drugs metabolized in kidneys Watch blood pressure Manage coagulative disorders Schedule procedures 24 hours after dialysis Watch out for the shunt Consider patients Hepatitis + Dialysis may remove drugs from blood
28
Pretreatment screening tests for coagulation disorders
``` Bleeding time Prothrombin time Partial thromboplastin time Hematocrit Hemoglobin ```
29
Shunt precautions
No cramped positions Avoid injections Avoid long sitting times Don't take blood pressure in the shunt arm
30
Surgical management for renal patients
``` Prophylactic antibiotics? Bleeding time Consider extra presurgical dialysis Local hemostasis- avitene Platelet transfusion if needed ```
31
Diabetes secondary problems
``` MI- most common cause of death Retinopathy Cataracts Stroke Amputation Renal failure Neuropathy Ulcers Fungal infections ```
32
Purpose of sulfonylureas
Stimulate production of insulin
33
Function of biguanides
Inhibit hepatic glucose production
34
Function of gamma-glucosidase drugs
Inhibit carbohydrate absorption
35
Function of thiazolidinedione drugs
Enhance insulin sensitivity
36
Signs of mild insulin reaction shock
``` Hunger Weakness Tachycardia Pallor Sweating parasthesia ```
37
Signs of moderate insulin shock
``` Incoherence Uncooperative Belligerence Judgement off Poor orientation ```
38
Signs of severe insulin shock
``` Unconscious Tonic-clonic movement Hypotension Hypothermia Rapid pulse ```
39
Treatment for severe insulin shock
IV glucose Glucagon Epinephrine if unconscious
40
Dental management considerations- patient with insulin controlled diabetes (5items)
- check they've had normal eating/injections that day - have glucose on hand - am appointment better - inform staff about signs of shock - consider antibiotic prophylactic for surgery
41
Dental treatment for uncontrolled diabetic patients
If elevated blood sugar and any other complication, do only emergency treatment and refer
42
Oral problems in diabetes
``` Caries Perio Odontogenic infections Xerostomia Salivary gland problems Poor healing Candida Lesions Dysplasia Mental health problems and not following dr orders ```
43
Symptoms of leukemia (5items)
``` Fatigue and malaise Unintentional weight loss Infections Back and abdominal pain Bleeding and bruising ```
44
Oral signs of leukemia (6 items)
``` Hemorrhage Infections Ulcerations Gingival infiltrates and chloromas Lymphadenopathy Neural symptoms ```
45
Signs of lymphoma
Lymphadenopathy- rubbery, firm, not fixed Malaise, fatigue, low grade fever, night sweats Weight loss Pruritis
46
Risk factors for diabetes to watch out for in screening (7 items)
``` Parent with diabetes History of still births Large babies Obesity >40 Hypertension Lack of regular exercise ```
47
General medical problems associated with hyperthyroidism (5 items)
``` Adverse rxn to epinephrine Cardiac arrhythmia Congestive heart failure Other cardiovascular conditions thyrotoxic crisis precipitated by infections, surgical procedures ```
48
Medical problems associated with hypothyroidism (2 items)
Exaggerated response to CNS depressants, narcotic analgesics, sedatives Myxedemetous coma precip. by CNS depressants, surgery, infection
49
Causes of hyperthyroidism (10 items)
``` Graves' disease Toxic multinodular goiter Toxic adenoma Pituitary disorder Pituitary tumor Subacute thyroiditis- leaks hormone Thyroid hormone use Ectopic thyroid Metastatic thyroid cancer Iatrogenic overdose ```
50
Skin symptoms of hyperthyroidism
``` Warm moist skin Easy blushing Palmar erythema and sweating Pigmentation Fine thin hair Soft nails ```
51
Eyes symptoms of hyperthyroidism
``` Retracted lids, stare Lid lag Jerky eye movement Exophthalmos Ocular neuritis Ocular muscle weakness ```
52
Skeletal, gastrointestinal symptoms of hyperthyroidism
Osteoporosis Weight loss Increased appetite Pernicious anemia
53
Cardiovascular symptoms of hyperthyroidism
``` Palpitations Increased heart rate Arrhythmias Cardiomegaly Congestive heart failure Angina Myocardial infarction ```
54
CNS a symptoms of hyperthyroidism
``` Anxiety restlessness Sleep problems Impaired concentration Tremor Weakness ```
55
Symptoms of hyperthyroid crisis
``` Restlessness Nausea Vomiting Stomach pain Fever Sweating Tachycardia CHF Stupor Coma Hypotension ```
56
Treatment for hypothyroid crisis
``` Propythiouracil KI Steroids Hydrocortisone Glucose CPR ```
57
What to avoid with untreated hyperthyroidism
Surgery Epinephrine Amine pressors Treat acute infections
58
Adult hypothyroidism | Child hypothyroidism
Adults- myxedema | Children- cretinism
59
Some symptoms of hypothyroidism
``` Pale Reduced intelligence Goiter Dry skin Large tongue Coarse brittle hair ```
60
Untreated hypothyroidism patients are sensitive to
``` Narcotics Tranquilizers Cold Stress Surgery Infections ```
61
How to deal with a myxedematous coma
Get medical help Hydrocortisone CPR IV glucose and saline
62
Symptoms of multiple myeloma
``` Bence jones proteins in urine Lambda and kappa light chains Skeletal related events- bones are damaged Fever, fatigue, malaise, weight loss Renal dysfunction Peripheral neuropathy Hypercoagulability ```
63
B- cell malignancy is called
Plasmacytoma if one location | Multiple myeloma if several
64
Leukemia that affects children and older adults
Acute lymphoblastic
65
Leukemia that affects mostly older adults
Acute myelogenous | Chronic myelogenous
66
Treatment for chronic myelogenous leukemia
Hematopoietic cell transplant
67
Three phases of chronic myelogenous leukemia
Chronic Accelerated Blast crisis
68
Leukemia that rarely progresses to acute form
Chronic lymphocytic leukemia
69
Which populations are most affected by Hodgkin's lymphoma?
Young adults | Older adults over 55
70
Signs of graft vs host disease
Itching, redness, rash Jaundice/ other liver problems Nausea and vomiting Dry itchy eyes