Midterm Flashcards
Imatinib mechanism of action
Inhibit BCR-Abl tyrosine kinase in Philadelphia chromosome positive cancer cells
What do cytostatic cancer drugs do?
Target mechanisms involved in growth of cancer cells- as opposed to cytotoxic drugs, which randomly kill all cells.
Under what conditions are a hematopoietic cell transplant made?
- Recovery requires new marrow/ immune cells
2. Chemo/radiation treatment will destroy the marrow
Sources of hematopoietic stem cells for transplantation
- Self
2. HLA (human leukocyte antigen) matched donor- twin, relative, other
Types of stem cell transplant conditioning therapy
- Myeloablative- destroys stem cells
2. Nonmyeloablative- doesn’t kill stem cells
Treatment goals before chemotherapy
- Reduce infection risk- perio
- Stabilize dentition, function
- Eliminate trauma, irritation
- Reduce bleeding risk
Concerns in treating patients who are undergoing chemo
- Bleeding problems
- Infection control
- Wound healing
Preventing spread of infection in chemo patients
- Prophylactic antibiotics
- Dental treatment
- slow speed hand piece
- rubber dam
- high power suction
Precaution against bleeding problems in chemo patients
Administer platelets, coagulation agents
Sites most susceptible to oral mucositis
Non keratinized mucosa:
- labial
- buccal
- lateral, ventral tongue
- soft palate, oropharynx
Prevention of oral mucositis
Cryotherapy
Palifermin
Low energy laser
Basic care of oral mucositis
Bland rinses
Oral hygiene
Prophylactic antifungal and antiviral
Symptom management for oral mucositis
Topical anesthetics
Coating agents
Systemic analgesics
Causes of salivary gland dysfunction in cancer patients
Radiation
Chemo
Anti cholinergic medications
Dental developmental abnormalities associated with cancer
- agenesis of teeth
- microdontia
Most common causes of renal failure
Diabetes
Hypertension
Chronic glomuleronephritis
Signs of uremia
Nausea Vomiting Headache Vertigo Visual changes Seizures Azotemic breath
Electrolyte disturbances in renal failure
Metabolic acidosis
Hyperkalemia
PO4+
NA+
Renal failure- cardiovascular disease connection
Fluid buildup
Pulmonary edema
Hypertension
Blood disorders and renal failure
Anemia- decreased erythropoietin production
Coagulopathy- anticoagulant medication
How does renal failure lead to osteodystrophy?
Increased PO4++ retention leads to hyperparathyroidism, causing increased serum ca++, resorted from bone
Three conditions found in osteodystrophy in renal failure patients
Osteomalacia
Osteosclerosis
Osteitis fibrosa
Conservative renal failure management
Control fluid intake
Remove parathyroid
Medications
Limit protein intake
Two types of dialysis
Peritoneal- fluid placed in perotineal cavity to draw toxins, then drained.
Hemodialysis- blood is removed, filtered, and returned