Midterm 3 Flashcards
functions of the heart (4)
- generate blood pressure
- route blood - right side of heart brings blood to the lungs, left side to the rest of the body
- ensure one-way flow of blood - valves to prevent back flow
- regulate blood supply
pathway of blood through heart
enter right atrium from body through superior vena cava -> goes through tricuspid (AV) valve -> moves into right ventricle -> goes through pulmonary semilunar valve -> pushed into pulmonary arteries -> travels through lungs to be oxygenated -> enter into pulmonary veins -> enters into left atrium -> goes through bicuspid valve -> moves into left ventricle -> goes through aortic semilunar valve -> out to body tissues through aorta
conducting system of the heart
- autorhythmicity: heart can contract on its own without any neural or hormonal input
- achieved by the cardiac conduction system
- sinoatrial node (SA) node: group of conduction cells found in right atrium, distributes energy to network using conducting cells
- atrioventricular node (AV): group of conduction cells located in right atrium, sends signal from atrium to ventricle
- conducting cells: wires throughout the heart, responsible for sending signal from one place to another
internal pathways: pathways between SA and AV node - Purkinje fibres act as conduction pathway of signal along ventricles
- Bundle of His conducts signal to left atrium and ventricle
- maximum conduction rate at the AV node = 230 bpm
- pumping efficiency decreases at 180 bpm
- rates over 230 bpm can occur when the conduction system is damaged
- max limit is about 300-400 bpm
sinoatrial (SA) node
- located in right atrium
- contains pacemaker cells that maintain rhythm of heart beat
- connected to the AV node via the internal pathways in the atrial wall
- determines resting heart rate
- changes in membrane potential of pacemaker cells in the SA node affect the heart rate, faster heart beat causes it to reach threshold (-40 mV) faster, prepotential is steeper
atrioventricular (AV) node
- located in right atrium, take rhythm from SA node and sends it to ventricles
- slows impulse down, can’t have atria and ventricles contracting at the same time, giving atria time to finish contraction and blood to flow into ventricles before contracting them
- moves impulse to the atrioventricular (AV) bundle
pathway of conduction in the heart
- SA node activity and atrial activation begin, time 0ms
- stimulus spreads across the atrial surfaces and reaches the AV node, top of atria squeeze first, time 50ms
- there is a 100ms delay at the AV node, atrial contraction begins, time 150ms
- impulse travels along the inter ventricular septum within the AV bundle and the bundle branches of the Purkinje fibres and, by the moderator band, to the papillary muscles of the right ventricle, time 175ms
- impulse is distributed by Purkinje fibres and relayed throughout the ventricular myocardium, atrial contraction is completed, and ventricular contraction begins, time 225ms
AV bundle, bundle branches and Purkinje fibres
- AV bundle = bundle of His
- right and left bundle branches feed into left and right ventricles
- Purkinje fibres connect with muscle cells of ventricles
electrocardiogram main waves
- P wave: atrial depolarization caused by SA node
- atrial repolarization but QRS complex covers it
- QRS complex: ventricular depolarization caused by AV node
- T wave: ventricular repolarization
- PR interval: time between onset of P wave and QRS complex
arrhythmias
- abnormal heart rhythm
- SA node develops abnormal rhythm
- conduction pathway interrupted
- ectopic pacemaker
atrial fibrillation (AF)
- the impulses move over the atrial surface at rates of up to 500 bpm, the atrial wall quivers instead of producing an organized contraction
- the ventricular rate cannot follow the atrial rate and may remain within normal limits, even though the atria are now non-functional, their contribution to ventricular end-diastolic volume is so small the condition may go unnoticed in older individuals
- blood may start to clot in atria if it stays stationary for too long, clot then falls into ventricle and is pumped into lungs or to the body
ventricular tachycardia (VT)
- defined as four or more premature ventricular contractions (PVCs), arising from an ectopic source, without intervening normal beats
ventricular fibrillation (VF)
- responsible for the condition known as cardiac arrest
- VF is rapidly fatal because the ventricle quiver and stop pumping blood
heart block
- related to the P-R interval, measures performance of AV node
- first degree: P-R interval is extended
- second degree: P-R interval is skipped, dropped heart beat
- third degree: no AV node function, ventricles rendered useless
the cardiac cycle
- beginning of one heartbeat to the beginning of the next heartbeat
- contraction (systole) phase and relaxation (diastole) phase
- blood will move from high pressure to low pressure
- pressure increases during contraction phase
- valves open and close due to pressure
1. atrial systole
2. atrial diastole
3. ventricular systole
4. ventricular diastole
atrial systole
- atria begin to contract due to SA node
- pressure increases
- atria push blood into ventricle, 30% of volume of ventricle
- “topping up” ventricle
atrial diastole
- atria begin to relax
- continually filling while relaxed
ventricular systole
- two phases: isovolumetric ventricular contraction and ventricular ejection
isovolumetric ventricular contraction
- occurs during ventricular systole
- end-diastolic volume (EDV, 120 mL), amount of blood at end of diastole
- ventricular contraction
- heart valves remain closed, pressure increases
ventricular ejection
- occurs during ventricular systole
- pressure in ventricle exceeds pressure in aorta or pulmonary trunk, causes aortic and pulmonary valves to open
- valve opens, this is when arterial pressure is measured
- ventricles continue to contract
- pressure continues to increase, peaks, then decreases
- volume of blood ejected = stroke volume (SV), typically 70-80 mL, around 60% of EDV at rest
- blood remaining in ventricle at end of contraction = end systolic volume (ESV, 40 mL)
ventricular diastole
- all valves closed
- isovolumetric ventricular relaxation
- ventricular pressure decreases
- AV valves open and passive filling occurs (70%)
Wiggers diagram
look at it and practice labelling
heart sounds
- ausculation
- “Lubb” = start of ventricular contraction, AV valve closes
- “Dupp” = start of ventricular filling, semilunar (aortic and pulmonary) valve closes
cardiac output
- cardiac function over time
- cardiac output = amount of blood pumped by the left ventricle per minute
- Q (mL/min) = HR (beats/min) x SV (mL/beat)
- at rest, average Q is 6 L/min
- normal range of Q during heavy exercise is 20 L/min
- maximum for trained athletes exercising at peak levels is 40 L/min
factors affecting cardiac output
- heart rate (chronotropic factors): autonomic innervation and hormones
- stroke volume (inotropic factors): EDV -ESV