Midterm Flashcards
Endogenous acetylcholine effects which site(s)?
muscarinic, ganglionic, somatic motor
Muscarine effects which sites?
muscarinic
Pilocarpine effects which sites?
muscarinic (main), ganglionic (mild)
Arecoline effects which sites?
muscarinic, ganglionic
Physostigmine effects which sites?
muscarinic, ganglionic, somatic motor
Nicotine effects which sites?
ganglionic, somatic motor
Lobeline effects which sites?
ganglionic somatic motor
Endogenous norepineohrine effects which sites?
adrenergic
Ephedrine effects which sites?
adrenergic
Cocaine effects which sites?
adrenergic
Endogenous ach mechanism of action?
direct agonist
muscarine mechanism of action?
direct agonist
arecoline mechanism of action?
direct agonist
physostigmine mechanism of action?
inhibits the enzyme that breaks down ach
nicotine mechanism of action
direct agonist
lobeline mechanism of action
direct agonist
endogenous norepinephrine mechanism of action
direct agonist
ephedrine mechanism of action
direct agonist & also increases the release of norepinephrine from nerve terminus
cocaine mechanism of action
norepinephrine re-uptake inhibitor
pilocarpine mechanism of action
direct agonist
Scopolamine, atropine, ipatropium effects which sites?
Muscarinic
d-tubocurarine effects which sites?
ganglionic, somatic motor
botulinum toxin effects which sites?
muscarinic, ganglionic somatic
reserpine effects which sites?
adrenergic
nicotine (high doses) effects which sites?
ganglionic
nicotine (high doses) mechanism of action
Direct antagonist causing persistent depolarization that causes receptor to shut down
reserpine mechanism of action
damages vesicles that contain catecholamines and tryptamines in nerve terminus
botulinum toxin mechanism of action
decreases relealse of ach from nerve terminus
d-tubocurarine mechanism of action
direct antagonist at nicotonic receptors
scopolamine, atropine, ipatropium mechanism of action
direct antagonist
increased heart rate, dialted pupils, decreased GI motility, increased sweating
endogenous sympathetic response
increased heart rate, dilated pupils, decreased GI motility
Ephedrine, cocaine
increased heart rate, dilated pupils, increased mouth secretions, decreased GI motility, decreased sweating
Atropine, scopolamine
normal, heart rate, pupils, moth secretion and GI motility
Endogenous parasympathetic response
decreased heart rate, constricted pupils. increased mouth secretions, increased GI motility, increased sweating
muscarine, pilocarpinem arecoline, physostigmine
endogneous seratonin mechanism of action
direct agonist
endogenous DMT mechanism of action
direct agonist
DMT-Psychotria viridis mechanism of action
direct tryptamine agonist
LSD mechanism of action
direct agonist, re-uptake inhibitor, indolemine
Lysergol from Calviceps purpurea mechanism of action
direct tryptamine agonist, indolemine
Psilocybin & psilocin
direct tryptamine agonist, indolemine
Mescaline from Lophophora & Echinopsis
Direct tryptamine agonist, phenethylamine
MDMA (ectasy)
Direct agonist, phenethylamine
MDA
Direct agonist, phenethylamine
Ibogaine from Tabernanthe iboga
Direct tryaptamine agonist & kappa opioid receptor agonist
Hyperforin from Hypericum perforatum
re-uptake inhibitor
harmine, harmalie from Banisteriopsos caapi
Re-uptake inhibitor (MAO)
Gabtril
GABA re-uptake inhibitor
Valerian
GABA direct agonist
Kava
GABA agonist
Thujone
GABA antagoist
Picrotoxin
GABA antagonist
Illex paraguariensis
Contains chllorogenic acids
Forskalin
increases adenylate cyclase enzyme
caffeine
blocks adenosine receptor
cathinone
increase # of NT from nerve terminus
Methamphetamine and other derivatives
Increase release of NT from nerve terminus
bromocriptine & pergolide
direct agonist
salvinorin A
kappa opioid receptor agonist