Midterm 2 Review Qs Flashcards
Which antibody is NOT known to fix compliment?
A. anti-Jka
B. anti-P
C. anti-B
D. anti-k
D. anti-k
All Kidd Need Pretransfusion
Which antithetical pair is NOT a high/low incidence pair?
A. Lua/Lub
B. Dia/Dib
C.Fya/Fyb
D.K/k
C. Fya/Fyb
Even distribution in the Duffy antithetical pair
Which antibody is known to demonstrate dosage?
A. anti-Jka
B. anti-P
C. anti-Lea
D. Anti-U
A. anti - Jka
The dosage effect is most prominently identified in antibodies associated with the Duffy, Kidd, Rh and MNS blood group systems.
Which antigen system is the entry point for Plasmodium Falciparum?
A. MNS
B. Lutheran
C. Duffy
D. Rhesus
A. MNS
Duffy is P.vivax
Secretor status is coded on chromosome 19, which of the following systems is also on this chromosome?
A. Kell
B. Duffy
C. Lutheran
D. P/Glob
C. Lutheran
Which antigen system is involved in urea transport in the cell?
A. Duffy
B. Kell
C. Kidd
D. P
C. Kidd
Chromosome 18 codes for a multiphase human erythrocyte urea transport gene called HUT II. Important for urine concentration. Jk null red cells resist 2M urea lysis
Which antibody is associated with paroxysmal cold hemoglobinuria?
A. anti-P1
B. anti-P
C. anti-M
D. Anti-I
B. anti-P
anti-P1 has no special features. anti-M’s special feature is malaria, anti-I has no special features.
Which antibody classically gibes mixed field agglutination reactions?
A. anti-Lea
B. anti-Lub
C. anti-I
D. Anti-D
B. anti-Lub
Which antibody is considered a warm acting antibody?
A. anti-M
B. anti-N
C. anti-S
D. Anti-Lua
C. anti-S
Which phenotype is NOT a null phenotype
A. JK3-
B. U-
C. Fy(a-b-)
D. k-
D. k-
This is an antithetical pair of K.
Which antibody is most commonly associated with delayed hemolytic transfusion reactions?
A. anti-s
B. anti-k
C. anti-Lua
D. Anti-Jka
D. Anti-Jka
Kidd are mostly cause delayed hemolytic transfusion reactions.
Kidd antibodies are notorious for two things, having a high titer that goes away fast and for showing adage. This means a homozygous Jkb+ person could get a transfusion that immunizes them to make an anti-jha that would react with the transfused cells and then become not detectible within 3 weeks after it is formed. As the serological detectability of this antibody weakens, it will have stronger reactivity with homozygous cells than with heterozygous cells. This change in titer makes them a common cause of delayed hemolytic transfusion reactions because they often are not detectable serologically until the patient has been given incompatible blood.
Which of the following phenotypes may make an allo-anti-U?
A. M+N+,S+,s-
B. M+N-S-,s-
C. M-N+S-s+
D.M+N-S+s+
B. M+N-S-s-
Weiner found that all S-s- patients were also U- in 1953. high prevalence U antigen named for “universal prevalence.
Which phenotype is considered homozygous?
A. R1r”
B. Fy(a+b+)
C. JK(a-b+)
D. K+k+
C. JK (a-b+)
Your facility has a rule to not phenotype units for antigens that are <10% prevalent in the populations. Which clinically significant antibody might they miss?
A. E
B. Lea
C. S
D. K
D. K
E is 30%, Lea is 70%, and S is 50%.
Which Duffy phenotype is prevalent in the black population but nearly non-existent in caucasians?
A. Fy(a+b+)
B. Fy(a+b-)
C. Fy(a-b+)
D. Fy(a-b-)
D. Fy(a-b-)
This is rare in the white population. 68% in the black population and 0% in the asian population.
Of significance is the fact that Duffy null red cells are VERY common on African American cells. This ACKR1 is a receptor for pro inflammatory cytokine that are involved in activation of white blood cells, binding molecules responsible for cell-to-cell communication, and essentially acting as a biological sponge for excess chemokines.
Which antigen of the Kell system is more frequent in the black population?
A. K
B. Kpa
C. Jsa
D. Jka
C. Jsa
Jsa antigen prevalence is unique to African population - 20%. (Caucasian less than 0.1%)
The antigens that are rare for Black populations are K and Kpa.
Which antibody is produced by the p null phenotype?
A. anti-p
B. anti-P
C. anti-P1
D. Anti-PP1Pk
D. Anti-PP1Pk
This is the antibody that is against all in the P system.
This is naturally occurring in p(null) individuals, causes spontaneous abortions, cytotoxic properties (hemolysin), bind complement efficiency, wide thermic range.
Which antigen is created by the transferase that competes with Pk transferase?
A. I
B. N
C. Lea
D. H
D. H
I is just there. N and Lea are not part of the P system.
Which antigen is NOT strongly expressed at birth in cord blood?
A. K
B. I
C. Fya
D. M
B. I
reacts strong with adults, weak or negative with baby.
Babies start with little i and it becomes big I as they grow.
Which antigen activity is enhanced with treatment with enzymes?
A. MN
B. Duffy
C. Rh
D. None of them
C. Rh
Remember: Destroy No Luck a.k.a Duffy, MNS, Lutheran
Which antigen would NOT be found on glycophorin B?
A. M
B. N
C. S
D. s
A. M
You will see anti-M if you work with gel or tube screens. Anti-M is a common annoyance but not really clinically significant. Mostly you will try to warm it away. Anit-N is far less common mainly b/c of the antigen’s partial presence on the glycophorin B. Most common you will see anti-N formed after dialysis. You will see S/s in glycophorin B.
Which red cell morphology occurs commonly when Kell antigens are missing from the red cell surface?
A. Spherocytes
B. Acanthocytes
C. Hypochromasia
D. Resistance to lysis in 2M urea
B. Acanthocytes
Spherocytes are seen in Rh nulls, urea is seen in Kidd
How many units should you test to find 2 compatible blood units for a patient who has an anti-Fya?
A. 1
B. 3
C. 5
D. 10
C. 5
The frequency of Fya is 60%. 100%-60%= 40%. The calculation is 100/40 = 2.5 x 2 units = 5
How many units should you test to find 1 compatible blood unit for a patient who has an anti-K, anti-E and anti-S?
A.1
B. 3
C. 9
D. 5
B. 3
anti-K is 9%, anti-E is 30%, and anti-S is 50%. So .90x.50x.70 = 0.315 —> 100/0.315 = 3 X 1unit = 3
