Midterm 2 Review Qs Flashcards
Which antibody is NOT known to fix compliment?
A. anti-Jka
B. anti-P
C. anti-B
D. anti-k
D. anti-k
All Kidd Need Pretransfusion
Which antithetical pair is NOT a high/low incidence pair?
A. Lua/Lub
B. Dia/Dib
C.Fya/Fyb
D.K/k
C. Fya/Fyb
Even distribution in the Duffy antithetical pair
Which antibody is known to demonstrate dosage?
A. anti-Jka
B. anti-P
C. anti-Lea
D. Anti-U
A. anti - Jka
The dosage effect is most prominently identified in antibodies associated with the Duffy, Kidd, Rh and MNS blood group systems.
Which antigen system is the entry point for Plasmodium Falciparum?
A. MNS
B. Lutheran
C. Duffy
D. Rhesus
A. MNS
Duffy is P.vivax
Secretor status is coded on chromosome 19, which of the following systems is also on this chromosome?
A. Kell
B. Duffy
C. Lutheran
D. P/Glob
C. Lutheran
Which antigen system is involved in urea transport in the cell?
A. Duffy
B. Kell
C. Kidd
D. P
C. Kidd
Chromosome 18 codes for a multiphase human erythrocyte urea transport gene called HUT II. Important for urine concentration. Jk null red cells resist 2M urea lysis
Which antibody is associated with paroxysmal cold hemoglobinuria?
A. anti-P1
B. anti-P
C. anti-M
D. Anti-I
B. anti-P
anti-P1 has no special features. anti-M’s special feature is malaria, anti-I has no special features.
Which antibody classically gibes mixed field agglutination reactions?
A. anti-Lea
B. anti-Lub
C. anti-I
D. Anti-D
B. anti-Lub
Which antibody is considered a warm acting antibody?
A. anti-M
B. anti-N
C. anti-S
D. Anti-Lua
C. anti-S
Which phenotype is NOT a null phenotype
A. JK3-
B. U-
C. Fy(a-b-)
D. k-
D. k-
This is an antithetical pair of K.
Which antibody is most commonly associated with delayed hemolytic transfusion reactions?
A. anti-s
B. anti-k
C. anti-Lua
D. Anti-Jka
D. Anti-Jka
Kidd are mostly cause delayed hemolytic transfusion reactions.
Kidd antibodies are notorious for two things, having a high titer that goes away fast and for showing adage. This means a homozygous Jkb+ person could get a transfusion that immunizes them to make an anti-jha that would react with the transfused cells and then become not detectible within 3 weeks after it is formed. As the serological detectability of this antibody weakens, it will have stronger reactivity with homozygous cells than with heterozygous cells. This change in titer makes them a common cause of delayed hemolytic transfusion reactions because they often are not detectable serologically until the patient has been given incompatible blood.
Which of the following phenotypes may make an allo-anti-U?
A. M+N+,S+,s-
B. M+N-S-,s-
C. M-N+S-s+
D.M+N-S+s+
B. M+N-S-s-
Weiner found that all S-s- patients were also U- in 1953. high prevalence U antigen named for “universal prevalence.
Which phenotype is considered homozygous?
A. R1r”
B. Fy(a+b+)
C. JK(a-b+)
D. K+k+
C. JK (a-b+)
Your facility has a rule to not phenotype units for antigens that are <10% prevalent in the populations. Which clinically significant antibody might they miss?
A. E
B. Lea
C. S
D. K
D. K
E is 30%, Lea is 70%, and S is 50%.
Which Duffy phenotype is prevalent in the black population but nearly non-existent in caucasians?
A. Fy(a+b+)
B. Fy(a+b-)
C. Fy(a-b+)
D. Fy(a-b-)
D. Fy(a-b-)
This is rare in the white population. 68% in the black population and 0% in the asian population.
Of significance is the fact that Duffy null red cells are VERY common on African American cells. This ACKR1 is a receptor for pro inflammatory cytokine that are involved in activation of white blood cells, binding molecules responsible for cell-to-cell communication, and essentially acting as a biological sponge for excess chemokines.
