Midterm 2 Flashcards
Class I
dsDNA genome, -DNA > +RNA
Rolling circle replication
Class II
+ssDNA genome L, -ssDNA forms > +mRNA. -DNA degrades before assembly
Class III
dsRNA genome, > +RNA. Pre packed with replicase.
Class IV
+ssRNA genome, Replicase synthesizes -RNA > +RNA
Class V
-ssRNA genome, synthesizes +RNA, +strand replicates genome
Class VI
+ssRNA retrovirus, RT makes dsDNA > +RNA (& genome)
Class VII
dsDNA genome, +RNA from -DNA strand. RT makes genome from +RNA strand
B19
Class II, Parvovirus/5th disease, aerosol/contact and endocytosis, naked, icosahedral, hairpin that encodes 2 enzymes
Rotavirus
Class III, diarrhea, attenuated vaccine, naked + segmented, genome rep in nucleocapsule, assembled in viroplasm, fills lumen with electrolytes
Poliovirus
Class IV, airborne/fecal, 1:100 target CNS, vaccine inactive/attenuated, genome has PolyATail, lyses, VPg primer/facilitates binding, creates huge polyprotein
Influenza
Class V, aerosols, endempic, pandemic every 10 years, pneumonia, inactive/attenuated/mRNA vaccine, Spike Proteins (HA/NA), enveloped, virions bud from membrane
Retrovirus
Class VI, HIV, delayed provirus, enveloped, 2 genome copies, 4 Enzymes (RT, Integrase, protease, viral +RNA), gSP binds to T Cells. Genome > dsDNA, integrates w/host
Hepatitis B
Class VII, blood contact, recombinant vaccine, partial circular genome w/overlapping, RNA transcribes whole genome, translated or RT’ed in capsule
T4
Terminally redundant, make long cocatamer, cut at dif sites so each progeny is unique, avoid host defence by modifying cytosine
Lytic vs Lysogenic
Lytic has the genome replicate itself and then burst, while lysogenic has the virus integrate into the host genome so the cell replicates before going to the Lytic cycle
