midterm Flashcards

1
Q

INTRO

how is global hunger changing over time? where is it increasing/decreasing? what forms of malnutrition are increasing/decreasing?

A
  • global hunger is increasing and food insecurity and malnutrition is worsening
  • increasing most in south asia and subsaharan africa, improving in south america
  • forms of malnutrition increasing: obesity
  • forms of malnutrition decreasing: stunting, wasting, breastfeeding
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2
Q

INTRO

ways to boost finance productivity to improve global nutrition

A
  1. need to enhance coordination and consensus among stakeholders
  2. increase risk tolerance among donors
  3. more blended and innovative financing solutions
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3
Q

INTRO

4C’s

do we produce enough food?

A

contributory factors to the sharp rise in global hunger in 2019-2021
1. covid (supply chain disruptions)
2. cost (inflation, imports, exports)
3. climate crisis
4. conflict (war)

yes, we produce way more food than neededd

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4
Q

INTRO

population-level consequences of iron deficiency, malnutrition

WASH

A

reduced GDP → 2.8% lower than with good nutritional status
increased morbidity and mortality

WASH = water, sanitaton, hygiene

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5
Q

INTRO

proxy, undernutrition, overnutrition, malnutrition

what is food security?

A

undernutrition: not enough calories, protein, vitamins and minerals
overnutrition: too many calories, overconsumption of specific nutrients
malnutrition: both

food security: when all people, at all times, have physical and economic access to sufficient, safe, and nutritious food that meets their dietary needs and food preferences for an active and healthy life

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6
Q

MACROS

energy + how it’s measured, bomb calorimeter, kilocalorie

A

energy: ability to do work
* burns food in container surrounded by water, called a bomb calorimeter; measures energy released by burning food as heat, by measuring the increase in water temp
* 1 kcal = amount of energy required to raise 1 kg water by 1ºC

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7
Q

MACROS

what do we need food for: basal metabolism, physical activity, dietary thermogenesis

what tissues require more/less energy to sustain?

A

basal metabolism: energy required to maintain normal body functions while at rest; 60-75% of total kcal needs
physical activity: energy needed for muscular work; most variable, voluntary in Western contexts
dietary thermogenesis: energy to ingest and digest food
peristalsis: moving food through GI tract → contraction of muscles

body fat = less metabolically active, brain/liver/kidneys/muscle = more

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8
Q

MACROS

digestion: mechanical, chemical, absorption

A

mechanical: chewing, stomach breaking the food down physically
chemical: chemically breaking it down
absorption: process by which nutrients + other substances are transferred from digestive system into body fluids for transport throughout the body

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9
Q

MACROS

macronutrients: how much energy they contribute per g

what’s the other source of energy?

A

fat: 9 kcal/g
carbohydrates: 4 kcal/g
protein: 4 kcal/g

ALCOHOLLLLLL

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10
Q

MACROS

simple sugars: monosaccharides, disaccharides; famine foods

A

monosaccharides: glucose, fructose, galactose; can be absorbed as is without being broken down by digestive enzymes
disaccharides: sucrose (gl + fr), maltose (gl + gl), lactose (gl + gal), must be broken down into monosaccharides
famine food: foods that would otherwise be considered inedible, but are eaten during times of extreme food scarcity

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11
Q

MACROS

complex carbohydrates (polysaccharides): starch, glycogen, dietary fibre

A

starches: glucose molecules linked together
glycogen: storage form of glucose in liver and muscle → “animal starch”
dietary fibre: polysaccharide that can’t be digested bc we lack the enzymes → for preventing constipation, helps prevent cardiovascular disease on an epidemiological level → doesn’t add to energy

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12
Q

MACROS

functions of protein

what is protein made of? what factors to consider for protein intake

A
  • structural material in muscles, connective tissue, organs, hemoglobin
  • basic component of enzymes, hormones, transport, immune system
  • maintains and repairs protein-containing tissues
  • energy source

20 diff amino acids, 9 essential; quantity (ADMR) + quality (amino var)

soy is a complete plant protein → contains all the essential amino acids in sufficient quantity

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13
Q

MACROS

when are protein requirements increased? define limiting amino acid, complimentary protein

A

protein requirements are increased in some circumstances
* infections, burns, fever, surgery
* pregnancy
* breastfeeding
* infants and young children

limiting amino acid: amino acid in an incomplete protein that is present in least amount relative to the requirement for that amino acid, ex. lysine for cereal grains
complimentary proteins: a protein that is incomplete on its own, but becomes complete when combined with another protein source with a complimentary amino acid content

ex. legumes + cereals → falafel, rice + beans

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14
Q

MACROS

what if the diet contains too little protein? what if too much protein?

AMDR for protein

A

what if the diet contains too little protein?
* nutrient deficiencies are usually multiple
* ex. protein deficiency → vitamin B12, zinc, niacin, iron deficiencies

what if the diet contains too much protein?
* adults can consume up to 35% from protein without will effect
* if intake > 45%: nausea, weakness, diarrhea, and eventually death
* higher intakes linked to osteoporosis, kidney stones, cancer, heart disease, obesity

1-3 yrs: 5-20, 3-18 yrs: 10-30, 19+ yrs: 10-35

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15
Q

MACROS

functions of fat

A
  • concentrated energy source
  • carrier for essential fatty acids, fat soluble vitamins (D, E, A, K)
  • adds flavour and palatability to food
  • contributes to feeling of satiety
  • component of cell membranes, vitamin D, sex hormones

children have higher fat intake bc it’s energy-dense

higher fat intakes associated with lower risk of overall mortality

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16
Q

MACROS

types of fat: triglycerides, saturated fat

AMDR for fat

A

triglycerides
* 98% of dietary fat intake
* glycerol backbone + 3 fatty acids, which are either saturated or unsaturated
* used by cells for energy and tissue maintenance

saturated fat
* carbon atoms are attached to as many hydrogen atoms as possible → saturated with hydrogen
* solid at room temp
* usually found in animal products, ex. marbling of beef; exceptions are palm oil, coconut oil

1-3 yrs: 30-40, 4-18 yrs: 25-35, 19+ yrs: 10-35

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17
Q

MACROS

types of fat: unsaturated fat, cholesterol

A

unsaturated fat
* contain fewer than the maximum hydrogens
* at least 1 double bond between carbons
* liquid at room temp, ex. plant food
* monounsaturated: only 1 double bond between carbons
* polyunsaturated: >1 double bond between carbons → omega-3 (alpha-linoleic acid), omega-6 (linoleic acid)
* polyunsatutrated includes EPA, DHA, trans fats

cholesterol: animal fat

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18
Q

MACROS

vitamins, water-soluble, fat-soluble

why does B12 deficiency take longer to develop?

A

vitamins: chemical substances that perform specific functions in the body
* 13 vitamins: 4 fat-soluble, 9 water-soluble
* must be consumed in small amounts; body can’t produce them in sufficient amounts
* vitamin D → produced by body in the presence of sunlight

water-soluble vitamins: C, B vitamins
* only small amounts stored in body
* intake beyond body’s needs is excreted in the urine
* deficiencies can develop quickly if intake is insufficient, EXCEPT B12 → takes a long time because B12 is re-circulated throughout the body → cognitive symptoms; irreversible

fat-soluble vitamins: D, E, A, K
* stored in body, primarily in fat and the liver
* because extra is stored in the body, symptoms of deficiency take a longer time to develop
* can overconsume since it’s stored in the body

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19
Q

MACROS

minerals + how they’re absorbed and used

how many are essential? define bioavailability

A

minerals: specific, single atoms that perform particular functions in the body
* human body contains 40+ minerals; only 15 are essential
* bc minerals are charged, they can combine w minerals with the opposite charge, and form stable compounds that become parts of tissue
* their electric charge can stipulate muscles to contract and nerves to fire
* can combine with other substances in food to form stable compounds that are not easily absorbed
* ex. tannic acid from tea binds to iron in the small intestine, preventing absoption

bioavailability: % that is absorbed and used by body

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20
Q

NUTRITION ASSESSMENT

nutrition assessment, nutritional status, ABCD

A

nutrition assessment: measures impact of nutritional programs; provides baseline for nutritional status
nutritional status: measurement of the extent to which the indiv’s physiologic need for nutrients is being met
A = anthropometric (H, W, MUAC)
B = biochemical
C = clinical
D = dietary

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21
Q

NUTRITION ASSESSMENT

define SAM and MAM. how do we know if someone has SAM or MAM?

what does MUAC reveal?

A

compare to WHO standards, which are universal across ethnic groups
SAM = severe acute malnutrition; weight for height is >= -3 SD below standard; MUAC < 11.5 cm
MAM = moderate acute malnutrition; w/h is between -2 and -3 SD below WHO standard; MUAC < 12.5 cm

MUAC only reveals wasting, not stunting!

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22
Q

NUTRITION ASSESSMENT

stunting vs wasting vs underweight, what it reflects + how stunting is measured

A

stunting = low height for age; reflects chronic malnutrition
* -2 SD below WHO standard
* also stunts cognitive growth
* measured using recumbent length

wasting = low weight for height; reflects acute malnutrition
underweight = low weight for age; reflects chronic OR acute malnutrition

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23
Q

NUTRITION ASSESSMENT

biochemical measurements

A

measures a nutrient or its metabolite in blood, urine, feces; or measures other components related to nutritional status

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24
Q

NUTRITION ASSESSMENT

clinical measurements, signs, symptoms

limitations of physical exams

A

Clinical: uses medical history and physical exam to detect and interpret the signs and symptoms of malnutrition
signs: observed by a trained examiner; affected person is usually unaware of them
symptoms: subjective, reported by affected person
* not specific enough to a specific deficiency
* can be non-nutritional factors
* examiner inconsistencies
* inter-individual variability

25
# NUTRITION ASSESSMENT signs of protein deficiency + how to test for edema
depigmentation of hair, traverse ridging on nails, edema (swelling due to excess fluid accumulation) **bilateral pitting edema:** sign of SAM; press feet gently with thumbs for 3 seconds → if there’s a dent on both feet, then pitting edema
26
# NUTRITION ASSESSMENT dietary measurements, 24 hour recall
**Dietary:** measurements of foods and beverages consumed by a person in 1 day, several days, or a longer time period **24-hour recall:** participant asked for quick list of foods/beverages consumed in the past 24 hours; quick/cheap/easy/doesn't alter diet, but relies on memory accuracy + labour intensive data entry + not representative
27
# NUTRITION ASSESSMENT dietary measurements: food records, food frequency questionnaires
**food records:** records type and amount of food/beverage consumed for a period of time; more detailed + representative but requires literacy + might alter diet/not represent usual intake **FFQ:** can determine how often person consumes a limited number of foods; can be self-administered + machine readable, but might not include usually consumed foods/portion size info, requires literacy
28
# HUNGER AND MALNUTRITION IN THE 21ST CENTURY malnutrition, undernutrition, maternal underweight, overweight and obesity
**malnutrition** = hunger, micronutrient deficiencies, overweight/obesity **undernutrition** = nutritional deficiency, maternal underweight. child stuntint + wasting, micronutrient deficiencies **maternal underweight:** BMI < 18.5 among women of reproductive age; prevalence > 20% = serious health problems **overweight and obesity:** BMI >= 25 = overweight, BMI >= 30 = obesity
29
# HUNGER AND MALNUTRITION IN THE 21ST CENTURY hunger + how it is linked to global disease risk
**hunger:** individual sensations, behavioural responses, food scarcity (actual or feared), national food balance sheets based on kcal * dietary risk factors + physical inactivity accounts for 10% of global burden of disease * 6/11 of global disease risk factors related to diet: incl undernutrition, high BMI, high cholesterol
30
# HUNGER AND MALNUTRITION IN THE 21ST CENTURY where is undernutrition decreasing?
undernutrition decreasing in china, brazil, ethiopia, bangladesh * brazil: maternal and child health services in underserved regions, social reform and safety net programs, equitable poverty reduction, food supplementation * ethiopia: increased enrolment and retention of girls in school, agricultural productivity, employment based safety net; treating nutrition as a multisector challenge, improved sanitation * bangladesh: economic growth policies, girls’ education, improved sanitation, agricultural investment
31
# HUNGER AND MALNUTRITION IN THE 21ST CENTURY what causes famine? where has the greatest risk of famine?
africa and asia have highest extreme poverty; greatest risk of famine * famine mostly due to human induced crises, like political mismanagement, armed conflict, discrimination of marginalized political/ethnic groups → compounded the effects of environmental shocks like droughts, locust invasions * cause of mortality in famines: wasting in children
32
# HUNGER AND MALNUTRITION IN THE 21ST CENTURY triple purpose
* eradicate hunger * resolve all forms of undernutrition * tackle obesity * need triple duty investments bc wealth and food sufficiency won’t resolve low quality diets
33
# HUNGER AND MALNUTRITION IN THE 21ST CENTURY effective actions to tackle hunger and malnutrition
* equitable growth policies → reduce poverty overall * targeted safety nets for the poor, invest in accessible services (education, clean water, healthcare) * govs should assume responsibility for responding to shocks (economic, environmental, conflict) * nutrition-specific programming → preventing, resolving defined nutrition problems (price support interventions, support for women farmers) * healthcare investment esp in maternity care
34
# NUTRITION ASSESSMENT nutrition transition + double burden of malnutrition
**nutrition transition:** notable changes in dietary intake and physical activity that, together, increase the prevalence of overweight and obesity in a society **double burden of malnutrition:** over- and undernutrition coexisting within the same country, family, or person
35
# MALNUTRITION causes and consequences of hagirso's undernutrition
causes * mother was malnourished during pregnancy * rationed food during hunger season * drought of 2003 → mother left vulnerable consequences * physically stunted * possibly cognitively stunted * economic cost of stunting: $3.5 tril in diminished education, lost * productivity, higher healthcare costs * stunted ambitions
36
# UNICEF FRAMEWORK basic causes, underlying causes, immediate causes | double burden of disease and malnutrition
**basic causes:** act upon society, * sociocultural, economic, political context * inadequate financial/human/physical/social capital * lack of access to resources (land, education, employment, income, tech) **underlying causes:** act upon communities * household food insecurity * inadequate care and feeding practices * unhealthy household environment + inadequate health services **immediate causes:** act upon the individual * inadequate dietary intake * disease > impairs absorption of nutrients, reduces appetite
37
# UNICEF FRAMEWORK short-term & long-term consequences
**short-term consequences:** mortality, morbidity, disability **long-term consequences:** adult height, cognitive ability, economic productivity, reproductive performance, metabolic and cardiovascular disease
38
# UNICEF FRAMEWORK updated version: differences | how to find upstream causes
1. positive narrative, focuses on positive outcomes 2. more about determinants and outcomes, not causes and consequences | ask WHY 5 times
39
# MICRONUTRIENT MALNUTRITION iron deficiency: biochemical and clinical markers
**biochemical markers:** hemoglobin (less oxygen carried to tissues), serum ferritin (storage form of iron) **clinical markers:** pale conjunctiva (less blood), anemia
40
# MICRONUTRIENT MALNUTRITION causes and consequences of iron deficiency | iron req for men vs women
causes of iron deficiency: * low dietary intake → plus underlying and basic causes * poor absorption → phys reasons, ex. diarrhea, or dietary reasons, ex. low bioavailability in plant foods, ex. black tea limits absorption * increased need → growth, pregnancy, lactation * infections → malaria, hookworms, tuberculosis consequences * children born from iron-deficient mother: premature birth, low birthweight, incr risk of infections, death, impaired physical growth * impaired cognitive development, negative impact on learning * reduced productivity, incr likelihood of death during childbirth → blood loss can be fatal * accounts for 20% of all maternal deaths | 8 mg/day vs 18 mg > 1000 kcal of a mixed diet provides 6 mg of iron
41
# MICRONUTRIENT MALNUTRITION what can be done about iron deficiency
change diet to increase iron intake * dietary diversification * increase enhancers, and reduce inhibitors of iron fortification * industrial: ex. wheat flour; ROI is $15000 per person per lifetime, only costs $2 to fortify wheat flour * household: micronutrient powder (sprinkles); easy, highly acceptable, can be added to any soft cooked food, encapsulated in lipid to prevent transfer of taste to other food control hookworm and other infections that cause anemia * lives in the small intestine of host * wear shoes
42
# MICRONUTRIENT MALNUTRITION types of iron
**heme:** part of hemoglobin and myoglobin, only in blood and muscle * more absorbable; 25% of iron absorbed, but only 10% of iron present in mixed diet **non-heme:** found in both animal and plant foods, not in hemoglobin and myoglobin * animal tissue is 40% heme, 60% non-home * eggs and dairy only have non-heme
43
# MICRONUTRIENT MALNUTRITION zinc deficiency consequences + foods it is found in | how to treat diarrheal infection
* contributes to growth failure, weakened immunity * 800K child deaths per year → from diarrhea, pneumonia, malaria * negative health consequences: central nervous system , skeleton, digestive system, immune system * found in whole grains, beans fortified cereals, meat, fish, poultry, and seafood | oral rehydration salts (ORS), zinc supplements ## Footnote zinc supplements can help reduce diarrheal mortality by 50%
44
# MICRONUTRIENT MALNUTRITION iodine deficiency: consequences, cretinism
* major preventable cause of intellectual disability * iodine deficiency in pregnancy leads to ~20 mil infants born with cognitive and growth impairments * **cretinism:** severely stunted physical and mental growth due to maternal hypothyroidism * goiter: swelling in thyroid gland
45
# MICRONUTRIENT MALNUTRITION sources of iodine
seafood cereals grown in iodine-rich soils milk → if soil is iodine-rich fortified foods > salt
46
# MALNUTRITION marasmus, kwashiorkor, marasmic-kwashiorkor
**marasmus:** wasting, severe weight loss; results in losing >30% of protein → less strength for breathing, susceptibility to infections, abnormal organ function, death * body becoming more efficient w energy usage; can be easier to recover from **kwashiorkor:** nutritional edema, bilateral pitting edema, bloated/water retention * can obscure wasting occurring concurrently → prevents early diagnosis of growth failure **marasmic-kwashiorkor:** combination of wasting (low MUAC) and bilateral edema; form of SAM
47
# MICRONUTRIENT MALNUTRITION anemia + geographic prevalence | who is at greatest risk of developing micronutrient deficiencies?
**anemia:** iron or vitamin B12 deficiency * individual’s blood lacks enough red blood cells to carry oxygen efficiently around the body * anemia in women/children: ⅓ are anemic * highest in south asia, sub-saharan africa | pregnant women and young children
48
# MICRONUTRIENT MALNUTRITION vitamin A deficiency: consequences, who is most vulnerable | in what foods is it found?
* leading cause of preventable blindness in children → starts as night blindness and progresses to permanent blindness * exacerbates serious disease and illness → leads to incr rates of maternal and childhood mortality * children under the age of 5 are most vulnerable * highest across Africa and Asia incl east Asia, North Africa; night blindness has the same pattern | leafy veg, yellow veg, dairy, fish, eggs, palm oil; BREAST MILK
49
# MICRONUTRIENT MALNUTRITION global hidden hunger index + where it's high
* metric used to indicate the severity of micro-malnutrition * used commonly for preschool children * average of prevalence of stunting, anemia, and vitamin A deficiency * alarmingly high in sub-saharan Africa and South Asia
50
# MICRONUTRIENT MALNUTRITION preventing and treating micronutrient deficiency + examples of each | what demographic factors influence micronutrient deficiency?
**supplementation:** use of concentrated micronutrients in pill, powder, or liquid form * vitamin A supplementation: countries provide at least 2 high-dose capsules over a year → relatively common in Africa and South Asia * oral rehydration salts to treat diarrhea **food fortification:** small amounts of micronutrients added to common food products used by the general population, such as cereals, wheat flour, and rice * ex. iodized salt supply **biofortification:** agronomic and plant-breeding approaches in agriculture are used to increase the concentration of particular micronutrients in staple food crops * ex golden rice → high concentration of vitamin A | poor dietary diversity (higher share of cereals/roots/tubers), income
51
# BREASTFEEDING describe the cycle of malnutriton in women
1. infant girls: low birth weight, growth restriction in womb, risk diarrhea, learning difficulties 2. girls are breastfed 6-8 weeks less, in the hope that the mother will become pregnant sooner with a boy 2. young girls have stunted growth, wasting, rickets, learning difficulties 3. teen: delayed menarche, narrow pelvis 4. women begin having babies as soon as puberty is reached; high risk of micronutrient deficiencies esp anemia; goiter, infection 5. pregnancy: more birth complications, risk anemia → goes back to infant girls | only 42% are exclusively breastfed for the first 6 months
52
# BREASTFEEDING how breast milk composition changes over time | how breast milk contributes micronutrients
1. colostrum → thick honey-like, secreted for first 2-3 days; nutritious, concentrated, mild laxative, contains growth factors and antibodies; only consumes ~1 tsp of colostrum in a feeding 2. transitional milk → until infant ~2 weeks old 3. mature milk → 2 wks - 6 months 4. extended lactation → beyond 6 months | high bioavail of iron, immunoglobulins, WBC, lysozymes, lactoferrin
53
# BREASTFEEDING how breast milk composition changes within a feeding | feeding tips
foremilk → watery hindmilk → high fat; more energy and vitamin A dense | drain one breast before offering the other one
54
# BREASTFEEDING WHO guidelines (1-6-24) + challenges | complementary foods?
exclusive breastfeeding from 1 hour - 6 months, introduce complementary foods at 6 months but continue breastfeeding until 24+ months * timing of introduction: too early/lae * may not be nutritionally adequate * may be unsafe | iron-rich, fatty (energy-dense)
55
# BREASTFEEDING benefits for mother and child
reduced risk of infant mortality * following WHO recommendations would save 800,000 child lives + 300 bil USD every year * better breastfeeding practices reduces all-cause mortality among infants reduced risk of postpartum hemorrhage * if mother can breastfeed shortly after delivery increased birth spacing → interval of at least 24 months between birth and next conception → better health outcomes * lactational amenorrhea → 98% protection against pregnancy for 6 months, if the baby feeds frequently day and night, and not given any other food, drinks, or a pacifier * also reduces ovarian cancer
56
# BREASTFEEDING should HIV+ women breastfeed their infant? | ARVs
if a safe alternative to breastmilk is available, use that safe alternative * formula w safe water, or safe donor breast milk if not available: breastfeed + ARV, follow WHO guidelines * but breastfeeding should stop once nutritionally adequate and safe diet without breast milk can be provided * much higher risks if not breastfeeding esp if diarrhea, pneumonia etc is common | antiretroviral medications
57
# NUTRITION TRANSITION 5 stages of the nutrition transition
1. hunter-gatherer 2. modern agriculture and famine 3. receding famine (as incomes grow) 4. changes in activity levels and diet lead to increased levels of noncommunicable diseases 5. behavioural change in which populations reduce their fat, increase fiber intake, and do meaningful physical activity that extends mortality and reduces NCDs * fiber bc it increases satiety
58
# MICRONUTRIENT DEFICIENCIES who is most vulnerable to vitamin A deficiency?
children under 5, people in poverty, rice-dominant countries, pregnant and lactating women (higher vitamin A req)
59
# BREASTFEEDING difference between canadian and mongolian breastfeeding cultures
canada: * very private * weaning is the goal * associated with dependency mongolia: * very public, encouraged, celebrated, normalized * weaning is not the goal * not associated with dependency; associated with strength and good wrestling * only stop when the child wants to stop * even adults drink breast milk; used medicinally * used to pacify children