MIDTERM Flashcards
Ointments came from a latin word?
Unguentum
Semisolid preparations applied on skin and mucous membranes
OINTMENTS
Ointment Bases
Oleaginous Bases
Absorption Bases
Water-Removal Bases
Water-Soluble Bases
Other termed for oleaginous base
Hydrocarbon Base
It is greasy, anhydrous, emollient, occlusive effect, non-water washable
OLEAGINOUS BASE
Most common brand name of Petrolatum USP
VASELINE
Mixture if semisolid hydrocarbon from petrolatum
PETROLATUM USP/YELLOW PETROLATUM/ PETROLEUM JELLY
Bleached form of Petrolatum USP
WHITE PETROLATUM
From honeybees/ honeycomb of Apis Mellifera
YELLOW WAX/BEESWAX
Honeycomb of?
APIS MELLIFERA
Bleached form of yellow wax or bees wax
WHITE WAX
It is a combination of yellow petrolatum + yellow wax
YELLOW OINTMENT/SIMPLE OINTMENT
White Petrolatum + White Wax
WHITE OINTMENT
Greasy
Anhydrous
Emollient
Occlusive Effect
Non-water Washable
(Can absorb small amount of water > will form w/)
ABSORPTION BASE
Brand name example of hydrophilic petrolatum
AQUAPHOR
Contains:
White wax
White Petrolatum
Stearyl Alcohol
Cholesterol
HYDROPHILIC PETROLATUM (AQUAPHOR)
From wool of sheep (Ovis Aries)
ANHYDROUS LANOLIN (WOOLFAT)
It contains 0.25% moisture
ANHYDROUS LANOLIN (WOOLFAT)
NOTE: HYDROUS LANOLIN 25% MOISTURE
•o/w emulsions
• non greasy, non-occlusive, water washable
•can be diluted with large amount of water
WATER-REMOVABLE BASE
Example is Hydrophilic Ointment
WATER-REMOMABLE BASE
the wool of sheep (scientific name)
Ovis aries
lipid-free
greaseless
Non-occlusive
Water washable
WATER-SOLUBLE BASE
For incorporation of solid substances
WATER-SOLUBLE BASE
MW of less than 600 <600
CLEAR, COLORLESS LIQUID
CLEAR COLORLESS LIQUID
LESS THEN 600 (<600)
Molecular weight more than 1000
>1000
WAX-LIKE, WHITE SOLID
WAX LIKE, WHITE SOLID
MORE THEN 1000
>1000
Molecular weight 600-1000
SEMI SOLID
2 methods of manufacture of ointments
INCORPORATION
FUSION
Use of ointment roller mills to mix heat-sensitive ointment bases
INCORPORATION
Use of steam-jacketed kettles to melts anhydrous ointment bases and cooling gradually until congealed.
FUSION
Semi-solid creams form in which the drug is dissolved or dispersed in either o/w or w/o emulsion base or any type of water-removable base.
CREAMS
More liquid in consistency than ointment therefore more spreadable to the skin.
CREAMS