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Blood Bank Rotation > Midterm > Flashcards

Midterm Flashcards

1
Q

Patient has colon cancer and a lower GI bleed
Anti-A : 4+
Anti-B : 1+
Anti-D : 4+
A1 : 0
B : 4+
What is the discrepancy? What is the blood type? What caused the discrepancy? What can be safely transfused?

A

Probable acquired B phenotype
A pos blood type
Discrepancy caused by GI bleed
Can receive A+, A=, O= and O+

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2
Q

Patient has pre-op labs before hysterectomy
Anti-A : 4+
Anti-B : 0
Anti-D : 4+
A1 : 2+
B : 4+
What is the discrepancy? What additional testing should be done? What is the blood type? What blood should be on hold?

A

A subgroup
A1 lectin
A2 pos
O+ AHG crossmatched

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3
Q

Patient has multiple myeloma
Anti-A : 4+
Anti-B : 4+
Anti-D : 4+
A1 : 1+
B : 1+
What discrepancy? How to resolve?

A

Rouleaux or cold auto antibody
Wash RBCs and repeat test, test for cold autoantibodies

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4
Q

Why is a history of multiple myeloma significant for blood bank?

A

it can cause rouleaux

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5
Q

What drug prescribed for multiple myeloma causes problems with antibody testing and Why? What would the screen and panel look like?

A

Darzalex is often mistaken as autoantibody or alloantibody and causes pan-reactivity. The DAT can be positive

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6
Q

Chimerism and how it affects blood typing

A

Chimerism is a mixture of donor and recipient cell populations after hematopoetic stem cell transplants. This determines if there was a successful transplant and if further testing in needed

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7
Q

R0

A

cDe

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8
Q

R1

A

CDe

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9
Q

R2

A

cDE

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10
Q

Rz

A

CDE

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11
Q

r

A

cde

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12
Q

r’

A

Cde

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13
Q

r’’

A

cdE

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14
Q

ry

A

CdE

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15
Q

A x B possible phenotypes

A

A, B, AB, O

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16
Q

AB x AB possible phenotypes

A

A, B, AB

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17
Q

B x B possible phenotypes

A

B, O

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18
Q

O x O possible phenotypes

A

O

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19
Q

Rr x rr possible phenotypes

A

Rr, rr

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20
Q

A x O possible phenotypes

A

A, O

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21
Q

AB x A possible phenotypes

A

A, B, AB

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22
Q

AB x O possible phenotypes

A

A, B

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23
Q

Why do we test for weak D?

A

To make sure the patient in negative and to see if patient is a candidate for Rhogam, and to make anti-D transfusion decisions

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24
Q

What testing method is used to test for weak D?

A

IAT

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25
Q

Why is it important to run a control sample along with the patient sample?

A

To make sure anti-sera is working and to make sure patient cells are not already coated with IgG

26
Q

Weak D

A

Quantitative change in D antigen expression, Rh positive

27
Q

Partial D

A

Qualitative change in D antigen usually from recombination wit C/E gene locus, can test as Rh positive but more alloantibodies to D antigen, transfuse with Rh negative blood and give RhD immune globulin to prevent hemolytic disease of the newborn

28
Q

What does in vivo mean?

A

The antibodies are bound to the RBCs inside the body

29
Q

What further testing does a positive adult DAT require?

A

monospecific DAT with Anti-IgG and anti-C3d

30
Q

What does the further testing in a positive adult DAT tell us?

A

If a person has autoimmune hemolytic anemia

31
Q

Elution

A

process that dissociates antigen-antibody complexes on RBCs, freed IgG antibody is tested for specificity

32
Q

Adsorption

A

technique using RBCs to remove RBC antibodies from a colution

33
Q

1 cause of transfusion reactions

A

Clerical errors

34
Q

HLA cause what kind of reaction?

A

Febrile

35
Q

ABO incompatibility causes what kind of reaction?

A

Acute hemolytic

36
Q

Alloantibody cause what kind of reaction?

A

Delayed hemolytic

37
Q

Transfusion of large volumes cause what kind of reaction?

A

TACO

38
Q

IgA deficiency cause what kind of reaction?

A

Anaphylactic

39
Q

O+ is compatible with

A

O+ and O=

40
Q

A+ is compatible with

A

A+, A=, O=, O+

41
Q

B+ is compatible with

A

B+, B=, O=, O+

42
Q

AB+ is compatible with

A

AB+. AB=, A+, A=, B+, B=, O+, O=

43
Q

O= is compatible with

A

O=

44
Q

A= is compatible with

A

A =, O=

45
Q

B= is compatible with

A

B=, O=

46
Q

AB= is compatible with

A

AB=, A=, B=, O=

47
Q

O plasma is compatible with

A

O, A, B, AB

48
Q

A plasma is compatible with

A

A, AB

49
Q

B plasma is compatible with

A

B, AB

50
Q

AB plasma is compatible with

A

AB

51
Q

How does a Rhogam injection affect patient panels?

A

Gives a passive anti-D

52
Q

Where are antigens located?

A

RBCs

53
Q

Where are antibodies located?

A

Serum

54
Q

Rh (D, C, E…)

A

IgG, dosage, warm, enzyme enhanced, HDFN

55
Q

Kell

A

IgG, no dosage, warm, HDFN

56
Q

Duffy

A

IgG, dosage, warm, enzyme suppressed, HDFN

57
Q

Kidd

A

IgG, dosage, warm enzyme enhanced, HDFN

58
Q

MNS

A

IgG or IgM, dosage, cold, enzyme suppressed

59
Q

Cold Auto/Anti-I

A

IgM, no dosage, cold, activate complement, may be seen at AHG phase if strong

60
Q

Warm Auto

A

IgG, no dosage, warm, pan-reactivity, associated with autoimmune disorders and certain drugs

Blood Bank Rotation (1 decks)

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