Midterm 1 Review Flashcards
Which of these develops from lymphoid stem cells?
Both T and B lymphocytes arise from lymphoid stem cells. Plasma cells are cloned from activated B lymphocytes.
What are functional characteristics of leukocytes?
positive chemotaxis, diapedesis, amoeboid motion
Which type of leukocyte provides protection against parasitic worms?
eosinophil
Which granular leukocytes act as our body’s bacteria killers and would dramatically increase in number during a bacterial infection?
Neutrophils
You are awaiting the white blood cell differential results for a patient who presented with a ruptured appendix and peritonitis. Which type of leukocyte do you expect to be most elevated over its normal value?
Neutrophils are the body’s bacteria slayers, so you would expect more of them to be present during a serious acute bacterial infection like the one your unfortunate patient has.
Which of the following mechanisms is NOT used to propel lymph through lymphatic vessels?
small, heart-like pumps
What is the unique structural modification in lymphatic capillaries that increases their permeability?
Minivalves
Which of the following promotes closure of the minivalves associated with lymph capillaries?
increasing pressure inside the lymph capillary. Minivalves will allow fluid in when external pressure exceeds internal pressure but will prevent fluid loss when the pressures are reversed.
Lymph from the right leg ultimately is delivered to which duct in the thoracic region?
The thoracic duct. It seems like odd plumbing, but lymph from the entire body below the diaphragm (both the right and left sides) enters the venous circulation via the thoracic duct.
Which of the following is NOT a function of the lymphatic system?
to return excess interstitial fluid to the bloodstream
to transport absorbed lipids from the small intestine to the bloodstream
to participate in gas exchange at capillaries
to carry pathogens towards lymph nodes
to participate in gas exchange at capillaries
Lymphatic capillaries are NOT found in __________.
Bone marrow. Lymphatic vessels are absent from bone marrow and teeth, as well as most of the central nervous system.
Which statement correctly describes the origin of lymph fluid?
Lymph is secreted into the lymph vessels.
Lymph is excess tissue fluid formed from plasma that has leaked from capillaries
Lymph is fluid collected from arteriovenous anastomoses.
Lymph is collected from fluid that accumulates in veins as blood slowly circulates back toward the heart.
Lymph is excess tissue fluid formed from plasma that has leaked from capillaries
As blood circulates through the body, nutrients, wastes, and gases are exchanged between the blood and the interstitial fluid. The hydrostatic and colloid osmotic pressures operating at capillary beds force fluid (plasma) out of the blood at the arterial ends of the beds and cause most of it to be reabsorbed at the venous ends. The fluid that remains behind in the tissue spaces, as much as 3 L daily, becomes part of the interstitial fluid. The lymphatic vessels collect this excess interstitial fluid (now called lymph) and return it to the bloodstream.
Which of these lymphoid organs is part of a collection of tissues called the mucosa-associated lymphoid tissues (MALT) and removes pathogens entering the pharynx (throat)?
The tonsils function to protect the throat and surrounding tissues from infection via the mouth and nose.
Which of these lymphoid organs is organized with trabeculae and compartments containing white pulp and red pulp?
The spleen is a large lymphoid organ containing areas of lymphocytes on reticular fibers (white pulp) and areas of reticular connective tissue cords and blood-filled sinuses (red pulp).
Which of the following lymphoid tissues/organs do(es) NOT contain reticular connective tissue?
The thymus is the only lymphoid organ that does not contain reticular connective tissue. The stroma of the thymus consists of epithelial cells rather than reticular fibers. These epithelial cells provide the physical and chemical environment in which T lymphocytes mature.
What region of the lymph node contains follicles filled with dividing B cells?
The cortex. The lymphoid follicles of the cortex contain germinal centers dominated by B cells, which produce antibodies against antigenic agents.
Which of the following is a role of lymph nodes?
They filter lymph.
They produce red blood cells.
They produce lymph.
They return lymph to circulation.
They filter lymph. Lymph nodes are rich with macrophages, B cells, and T cells; therefore, the lymph nodes are primed for activating the immune system. Structurally, lymph nodes have a capsule and medullary chords and sinuses that serve to filter lymph fluid.
Where is the spleen located?
The spleen is located in the left side of the abdominal cavity just beneath the diaphragm and is curled around the anterior aspect of the stomach. Its position leaves it vulnerable to damage in certain vehicle collisions.
Which tonsil is located in the posterior wall of the nasopharynx and is referred to as the adenoids if it is enlarged?
The pharyngeal tonsil is located in the posterior wall of the nasopharynx and is referred to as the adenoids if it is enlarged.
Which of the following organs or locations do(es) not contain MALT (mucosa-associated lymphoid tissue)?
Lymph nodes. Lymph nodes are not a component of MALT, as they are not associated with mucous membranes.
With what does our immune system coat pathogens to facilitate their capture and accelerate phagocytosis?
Opsonins. Opsonins are needed to provide a gripping point on some cells that have capsules or other defenses against adherence by phagocytes.
What characterizes the chemotaxis phase of phagocyte mobilization?
Neutrophils and other WBCs migrate up the gradient of chemotactic agents to the site of injury.
How do interferons protect against viral infection in healthy cells?
Interferons encourage the production of antiviral proteins. These antiviral proteins are coded in the cell’s DNA. These proteins can degrade viral RNA and interfere with viral protein synthesis.
Which of the following events is not directly associated with inflammatory responses?
antibody production. Inflammation is a component of the body’s innate defenses. Antibody-mediated (humoral) immunity is a component of adaptive defenses.
Which type of chemical induces fever?
Pyrogens target neurons in the hypothalamus to increase the set point for thermoregulation, raising body temperature above normal (37°C).
Which of the following is an effect of complement activation?
fever
tissue repair
T cell activation
opsonization
opsonization. Complement proteins stimulate inflammation, serve as opsonins to aid in the phagocytosis of targeted antigens, and facilitate cytolysis.
The percentage of blood volume occupied by erythrocytes is called the:
Hematocrit
The buffy coat that appears after a sample of blood has been centrifuged contains
White blood cells
Which of the following is not a role of albumin?
It acts as a blood buffer
It contributes to plasma osmotic pressure
It serves an immune system function
It acts as a carrier molecule
It serves an immune system function
Match the component of plasma with its description and/or importance: Globulins.
Involved in transport of lipids; involved in immune response
Match the component of plasma with its description and/or importance: Electrolytes
Sodium, calcium, potassium, chloride, phosphate, sulfate
Match the following function of blood with the correct example: Transport.
Delivering oxygen from the lungs
Match the component of plasma with its description and/or importance: Water
Ninety percent of plasma volume; dissolving and suspending medium for solutes of blood
Which of the following is a protective function of blood?
Preventing infection
A healthy adult male has approximately __________ liters of blood.
5 to 6
A major plasma protein that maintains the blood osmotic pressure is __________.
Albumin
Match the following part of separated blood with its definition: Hematocrit.
Erythrocyte portion of centrifuged blood
Match the following function of blood with the correct example: Regulation.
Match the following function of blood with the correct example: Regulation.
Match the component of plasma with its description and/or importance: Albumin.
Produced by liver; exerts osmotic pressure to maintain water balance between blood and tissues
Match the following part of separated blood with its definition: Plasma.
The liquid portion of centrifuged blood that sits atop everything else
Match the following disorder with the appropriate description: Sickle-cell anemia.
Caused by abnormal hemoglobin from a change in DNA, resulting in a change in one of the 146 amino acids of the beta chain of the globin molecule
Individuals with malaria have a better chance of surviving if they have which type of anemia?
Sickle-cell anemia
Erythropoietin is made primarily by the __________.
Kidneys
Which of the following factors has the greatest effect on making red blood cells (RBCs) very efficient oxygen transporters?
They generate ATP by anaerobic mechanisms and do not consume any of the oxygen they carry.
Aging red blood cells are fragmented and trapped mainly in the __________.
Capillaries of the spleen
One molecule of hemoglobin can bind a maximum of __________ oxygen molecules.
Four
Pernicious anemia may result from __________.
the lack of vitamin B12 in the diet or a deficiency of the intrinsic factor needed to absorb B12
Erythropoiesis is best defined as __________.
Red blood cell production
Mature red blood cells in the circulating blood are filled with __________.
Hemoglobin molecules
Choose the true statement about fetal hemoglobin.
Fetal hemoglobin is called hemoglobin A.
Fetal hemoglobin contains four alpha chains.
Fetal hemoglobin has a higher affinity for oxygen than does adult hemoglobin.
Fetal hemoglobin is produced until the baby is one year old.
Fetal hemoglobin has a higher affinity for oxygen than does adult hemoglobin.
The terms biconcave and anucleate apply to __________.
Red blood cells
Match the following disorder with the appropriate description: Hemorrhagic anemias.
Result from blood loss
Which type of anemia results from the destruction or inhibition of the red marrow by drugs, chemicals, ionizing radiation, or viruses?
Aplastic anemia
Match the following disorder with the appropriate description: Iron-deficiency anemia.
Can be a secondary result of hemorrhagic anemia, but it also results from inadequate diet or impaired absorption
Another term for reduced hemoglobin is __________.
deoxyhemoglobin
Erythroblastosis fetalis is caused by __________.
an Rh incompatibility between an Rh-negative mother and her Rh-positive baby during pregnancy
Match the following term with its correct description: Lymphocyte.
Small agranulocyte with a lifespan that varies from a few hours to decades
What is a function of neutrophils?
Phagocytize bacteria
The process of actively metabolizing oxygen by neutrophils to produce bleach and hydrogen to kill bacteria is known as __________.
the respiratory burst
The most numerous leukocyte is the __________.
neutrophil
Which of the following is a function of basophils?
Release histamine during an allergic reaction
Match the following term with its correct description: Basophil.
Bilobed nucleus and dark-staining cytoplasmic granules
Match the following term with its correct description: Macrophage.
Highly phagocytic cell with a U or kidney shaped nucleus
Which cell would be expected to be elevated in a chronic infection like tuberculosis?
Monocytes (macrophages). Macrophages are actively phagocytic, and they are crucial in the body’s defense against viruses, certain intracellular bacterial parasites, and chronic infections such as tuberculosis.
Which of the cells might rise in an illness associated with eating raw shellfish?
Eosinophils
The migration of white blood cells out of the capillary blood vessels is called __________.
Diapedesis
Overproduction of white blood cells is called __________.
Leukocytosis
Match the following term with its function: Play a critical role in immunity.
Lymphocytes
Match the following term with its correct description: Platelet-derived growth factor.
Stimulates blood vessel healing
Platelets are derived from __________.
Megakaryocytes
Match the following term with its function: Increase in number significantly during bacterial infections.
Neutrophils
Which of the following is considered a type of lymphocyte?
Neutrophils
Basophils
Macrophages
B-cells
B-cells
Match the following type of blood cell formed element with the appropriate description: Eosinophils.
Their deep purple nucleus has two lobes connected by a broad band of nuclear material; their large, coarse granules stain red with acid dyes.
Which cell would be expected to be elevated in a viral infection?
Lymphocytes
Which of the following types of white blood cells kills parasitic worms, destroys antibody complexes, and modulates the immune response?
Eosinophils
Match the following term with its function: Differentiate into macrophages
Monocytes
The most numerous leukocyte is the __________.
Neutrophil
Which of the following is a function of neutrophils?
Phagocytize bacteria
Which of the following types of white blood cells kills parasitic worms, destroys antibody complexes, and modulates the immune response?
Eosinophils
Which of the following is a function of lymphocytes?
Destruction of virus-containing cells
Diapedesis refers to __________.
the movement of leukocytes from blood vessels into tissue spaces
Match the following type of blood cell formed element with the appropriate description: Platelets.
Not complete cells, but fragments of cells; they are very small compared to other cellular components.
Which property do white blood cells (WBCs) have in common?
WBCs are nucleated and have a protective function.
The lining of the heart chambers is called the __________.
Endocardium
The vessels that carry oxygen to the myocardium are called __________.
Coronary arteries
The walls of the __________ are thicker than the walls of any other heart chamber.
Left ventricle
The endocardium is composed of __________.
Squamous epithelium