Midterm #1 Review Flashcards
In your own words, describe the size, location, and orientation of the heart
- The heart rests on the diaphragm, near the midline of the thoracic cavity.
- It lies in the mediastinum- an anatomical region that extends from the sternum to the vertebral column, from the first rib to the diaphragm, and between the lungs
The orientation of the heart
- The heart looks like a cone lying on its side. The pointed apex is formed by the tip of the left ventricle and rests on the diaphragm. It is directed anteriorly, inferiorly and to the left.
- The base of the heart is its posterior surface. Formed by the upper chambers of the heart, mostly the left atrium.
List the 4 valves of the heart – include all alternate names for each valve.
1) Tricuspid Valve: blood passing from the right atrium into the right ventricle.
Also called the Right atrioventricular valve
2) Bicuspid Valve: blood passes from left atrium into the left ventricle
Called Mitral valve and Left atrioventricular valve
3) Pulmonary Valve: blood passes from the right ventricle into a large artery called pulmonary trunk. It divides into right/left pulmonary arteries, carries to lungs
Semilunar Valve
4) Aortic Valve: blood passes from left ventricle through this valve, into the ascending aorta
Semilunar Valve
Cardiac Output
The amount of blood pumped by the ventricle (either right or left) in one minute
Cardiac Output (CO) = Stroke Volume (SV) X Heart rate (HR)
Cardiac Output (CO) = 70 mL X 75 bpm
Cardiac Output (CO) = 5250 mL/minute OR 5.25L/minute
Stroke Volume:
The volume of blood ejected by the ventricle during one contraction
EDV - ESV
The volume of blood in the ventricle after relaxation
End Diastolic Volume (EDV)
The volume of blood remaining in the ventricle after it contracts
End Systolic Volume (ESV)
Cardiac Reserve
he difference in cardiac output from the maximum output ( activity) to the minimum output ( activity).
The difference is usually 5-4 times the resting, or minimum, output
Cardiac Cycle:
Includes all the events associated with one heartbeat.
- Consists of systole and diastole of the atria plus systole and diastole of the ventricles.
- When a heart rate is 75 bpm, a cardiac cycle lasts 0.8 seconds
The cardiac muscle fibers are contracting isometrically, but they aren’t yet shortening. All 4 valves are closed, and there is no change in blood volume of any heart chambers at this point.
Isovolumetric Contraction
A brief period in the cardiac cycle when all 4 valves are closed and the heart wall is relaxed
Isovolumetric Relaxation
Depolarization
Contractile fibers have stable resting membrane potential close to -90 mV. When the fibers are brought to threshold by an action potential, its voltage-gated fast Na channels open. This allows Na inflow. This produces rapid depolarization. Within seconds Na channels inactivate and Na inflow decrease
Repolarization:
This is the recovery of the resting membrane potential
- After a delay, additional voltage-gated K channels open. Outflow of K restores the negative resting membrane potential (-90mV). At the same time, the Ca channels in the sarcolemma and the sarcoplasmic reticulum are closing which also contributes to repolarization.
Self-excitable specialized cardiac muscle fibers that is the source of electrical activity
- They repeatedly generate action potentials that trigger heart contractions
- Act as a pacemaker, and form cardiac conduction system
Autorhythmic fibres
Intercalated Discs
Irregular transverse thickenings of the sarcolemma connecting ends of cardiac muscle fibers
Gap Junctions:
Allow muscle action potentials to conduct from one muscle fiber to its neighbour
Purkinje Fibers
Rapidly conduct action potential beginning at the apex of the heart upward to the remainder of the ventricular myocardium. Then the ventricles contract, pushing blood up to semilunar valves
Preload:
How much stretch is placed on the fibers of the heart wall before contraction occurs.
(Think of a balloon - if the balloon is blown up to its maximum, that would be a higher preload. If the balloon was only blown up a little, that would mean a lower pre-load.
Afterload
The pressure required for the ventricles to eject the blood
What events will follow when the pressure within the atria is higher than that of the ventricles?
Atrial Contraction (Atrial Systole)
- Depolarization of SA node causes atrial depolarization, marked by P wave
- Atria contracts, expert pressure on blood within, forces blood through the open AV valves into ventricles
- Contributes final 25ml of blood to volume in each ventricle (105ml). At the end of martial systole it relaxes, it then contains 130ml in each ventricle
What events will follow when the pressure within the ventricles is higher than that of the atria?
Ventricular Depolarization (Ventricular Systole)
- Pressure rises inside ventricles and pushes blood up against the atrioventricular valves, forcing them shut. For 0.5 sec, both atrioventricular and semilunar valves are closed Isovolumetric contraction
- Continued contraction on ventricles causes pressure inside chambers to rise sharply. Left ventricle surpasses the aortic pressure of 80mmHg, Right ventricle rises above the pressure of the pulmonary trunk. Then both semilunar valves open ventricular ejection
- Ejection of blood from heart now begins, pressure of Left ventricle rises to about 120mmHg, Right ventricle climbs to 25-30mmHg
- Represents the T wave
What needs to happen for the semilunar valves to open? What is the term used to describe this event
Ventricular Ejection
- This is caused when the pressure inside chambers rise sharply
- Pressure in left and right ventricle climb above pressure in pulmonary trunk causes valves to open
What needs to happen for the Atrioventricular Valves to open?
- When ventricles begin to relax, and the pressure falls quickly below the atrial pressure, the AV valves then open.
- Ventricular Filling begins (blood flowing into the atria rushes rapidly into the ventricles after the AV valves open)
Describe Epicardium
-External Layer
Composed of 2 layers
-Outermost is visceral of serous pericardium
Innermost composed of delicate fibroelastic tissue and adipose tissue
-Contains blood vessels and lymphatic that supply myocardium
Describe Myocardium
- Middle Layer
- Responsible for pumping action of heart
- Composed of cardiac muscle tissue
- Makes up 95% of heart wall
Describe Endocardium
- Innermost Layer
- Thin layer of endothelium overlying a thing layer of connective tissue
- Smooth lining for chambers of the heart and covers valves
- Minimizes friction as blood passes
List and describe the 2 components of the pericardium:
- Fibrous -
- Tough inelastic, dense irregular connective tissue
- Prevents overstretching, protection, anchors the heart
- Serous-
- Thin, delicate membrane, double layer of heart
- Fused with fibrous pericardium on outside
- Inner visceral layal (epicardium), layer adheres tightly to surface of heart
- Pericardial fluid- reduces friction between layer as heart moves
- Pericardial cavity- has few ml of pericardial fluid
membrane surrounds and protects the heart. Anchors the heart in position in mediastinum
Pericardium
Sulci:
A series of grooves found on the surface of the heart
Contains coronary blood vessels and a variable amount of fat, each sulcus marks the external boundary between 2 chambers of the heart
Encircles most of the heart and marks the external boundary between the superior atria and inferior ventricles
Coronary Sulcus
Wrinkled pouch-like structure, slightly increase capacity of atrium so it can hold greater volume of blood
Auricles
What is the function of the heart valves? Without valves, what would happen?
The valves in the heart are to help close off the atrium to ventricles, and ventricles to the large artery. Without these valves the blood would flow back into the valve, and areas (backflow), and create things like a “leaky valve”
Which chamber of the heart receives deoxygenated blood from 3 major vessels?
The Right Atrium Receives blood from the 3 following veins: Superior Vena Cava Inferior Vena Cava Coronary Sinus
The pulmonary arteries project off of ______________ (which heart chamber) and carry _______ (oxygenated/deoxygenated) blood.
1) Right Ventricle
2) Oxygenated
The pulmonary veins project off of ______ (which heart chamber) and carry ______ (oxygenated/deoxygenated) blood.
1) Left Atrium
2) Oxygenated
Which structure begins as a passage between the atria in the fetal heart? If this passage does not close soon after birth, what complications do you think this could have for the baby?
- Fossa Ovalis: Oval depression that is the remnant of foramen ovale, opening of the interatrial septum of fetal heart and normally closes soon after birth
- If this doesn’t close, it would create what is called a “hole in the heart” meaning there would be blood flow between both atria’s, of deoxygenated and oxygenated blood causing issues with heart and blood flow
Compare the thickness of the myocardium for each of the four heart chambers – why does the thickness vary from each chamber?
Right Atrium: 2-3mm
Right Ventricle: 4-5 mm
Left Atrium: 2-3 mm
Left Ventricle: 10-15 mm
-Thickest varies because of what each chamber is doing, the amount of blood flow and how hard they are working.
-Because the Left Ventricle forms the apex of the heart and passes blood to the aorta, it is pumping blood to the entire body. It needs to be thicker because it is working much harder
List the surfaces of the heart
- Anterior surface- deep to the sternum and ribs
- Inferior surface- between the apex and right border
List the borders of the heart
- Right border- faces the lung and extends from the inferior surface to the base
- Left border- aka pulmonary border -faces the left lung and extends from the base to the apex
What structure of the heart acts as an electrical insulator between the atria and ventricles?
AV Nodes
Includes all arteries and arterioles that carry oxygenated blood from the left ventricle to systemic capillaries, plus the veins and venules that carry deoxygenated blood returning to the right atrium after flowing through body organs. Blood is bright red but becomes darker red
Systemic Circulation
Describe Pulmonary Circulation
- When blood is returned to the heart from the systemic route, it is pumped out of the right ventricle through the pulmonary trunk into the right and left pulmonary arteries to the lungs
- Bright red again, it returns to the left atrium of the heart and reenters the systemic circulation
How does the heart receive its blood supply?
Through the Coronary Arteries, via the Coronary circulation
At which point in the cardiac cycle do the coronary arteries fill?
When the heart relaxes after a contraction, the high pressure of blood in the aorta propels blood through the coronary arteries
Which arteries branch directly off the Arch of Aorta?
Brachiocephalic Trunk
Left Common Carotid Artery
Left Subclavian Artery
What is the name of the specific structure the aorta must pass through when it transitions from the thoracic aorta to the abdominal aorta? At which vertebral level does this transition happen?
Aortic Hiatus
Happens at level of T12 and ends at L4
List and describe the coronary arteries
1) Right Coronary Artery
Arises from the ascending aorta
Divides into the posterior interventricular and marginal branches
Supplies small branches to the right atrium.
2) Left Coronary Artery
Arises from the ascending aorta
Divides into the anterior interventricular and circumflex branches
3) Anterior Interventricular Branch (aka left anterior descending)
Arises from the left coronary artery
Supplies the walls of both ventricles
4) Circumflex Branch
Arises from the left coronary artery
Supplies the walls of the left ventricle and left atrium
5) Posterior interventricular branch
Arises from the right coronary artery
Supplies the walls of both ventricles
6) Marginal branch
Arises from the right coronary artery
Supplies the myocardium of right ventricle
List and describe the coronary veins
1)Coronary Sinus
Arises from the posterior surface of the heart in the coronary sulcus.
Empties into the right atrium
Remove deoxygenated blood from the heart
2) Great Cardiac Vein
Arise in the anterior interventricular sulcus
Removes deoxygenated blood from the left & right ventricles and left atrium
3) Middle Cardiac Vein
Arises in the posterior interventricular sulcus
Removes deoxygenated blood from the left and right ventricles
4) Small Cardiac Vein
Arises in the coronary sulcus
Removes deoxygenated blood from the right atrium and right ventricle
5) Anterior Cardiac Vein
Removes deoxygenated blood from the right ventricle and opens directly into the right atrium
What is Anastomosis?
This allows for alternate routes called “collateral circulation,” for blood to reach a particular organ or tissue. (Especially if there is damage or injury)
List and describe the 4 divisions of the aorta (include the vertebral levels)
1) Ascending Aorta
Emerges from left ventricle to pulmonary trunk
2) Aortic Arch
Emerges as the ascending aorta bends to the left and continues to level of IVD between T4-T5
3) Thoracic Aorta
Emerges from Aortic Arch to bottom of thorax, passes through aortic hiatus to diaphragm level T12
4) Abdominal Aorta
Emerges at aortic hiatus of diaphragm and ends at the level of L4, divides into common iliac arteries
List and describe (including the areas they supply) the 7 arterial branches that arise from the thoracic aorta
1) Pericardial Arteries
supplies the pericardium
2) Bronchial Arteries
supplies the bronchi of the lungs
3) Esophageal Arteries
supplies the esophagus
4) Mediastinal Arteries
supplies the structures in the mediastinum
5) Posterior Intercostal Arteries
supplies the intercostals and chest muscles
6) Subcostal Arteries
supplies the intercostals and chest muscles
7) Superior Phrenic Arteries
supplies the sup. & post. surface of diaphragm
Which arteries branch off the brachiocephalic trunk?
Right Subclavian artery
Right Common Carotid artery
Why is there no left brachiocephalic trunk?
Because the left common carotid and left subclavian arteries both arise directly from the aortic arch, which is on the Right side
The external carotid and internal carotid arteries are branches of which artery?
Left Common Carotid
What is the function of the vertebral arteries?
They unite to form the Basilar artery, which supplies blood to posterior part of the Circle of Willis
What are the paired parietal branches of the abdominal aorta?
Inferior Phrenic Arteries
Lumbar Arteries
What are the 6 visceral branches of the abdominal aorta?
–3 Paired–
Suprarenal Artery
Renal Artery
Gonadal Artery
–3 Unpaired–
Celiac Trunk
Superior Mesenteric Artery
Inferior Mesenteric Artery
Which parietal branch of the abdominal aorta is unpaired?
Median Sacral Artery
Which arteries unite to form the basilar artery?
Left the Right Vertebral Arteries
What are the branches of the left subclavian artery?
Left Vertebral
Left Axillary
What is the most appropriate positioning for a very pregnant client during massage? Why?
Side Lying on their left, or on their back with pillow propping up the left right side
Due to Inferior Vena Cava (IVC) and aorta on your right side, to ensure there is proper flow from the area and not compressing these structures
Which major vessel of the heart drains the head, neck, and upper limbs?
Superior Vena Cava (SVC)
Which major vessel of the heart drains the abdomen, pelvis, and lower limbs?
Inferior Vena Cava (IVC)
Explain the pathway of blood as it drains from the cranial cavity to the heart
All veins drain into Dural Venous Sinuses (Include: Sup. Sagittal, Inf. Sagittal, Straight, Sigmoid, Cavernous Sinuses) -> Internal Jugular Vein -> Subclavian vein -> Brachiocephalic vein -> SVC
- External Jugular vein -> Subclavian
- Vertebral vein -> Brachiocephalic -> SVC
Which three veins drain into the brachiocephalic vein?
Internal Jugular Vein
Subclavian Vein
Vertebral Vein
Explain the Lubb Sound
The first sound (S1) Lubb
- It is a bit longer than the second sound. It is caused by blood turbulence associated with closure of the AV valves soon after ventricular systole begins
Explain Dupp Sound
The second sound (S2) Dupp
-It is shorter and not as loud. It is caused by blood turbulence associated with closure of the SL valves at the beginning of ventricular diastole.
What is the function of Sodium (Na), Calcium (Ca) and Potassium (K) in the electrical conductivity of the heart?
1) Depolarization: due to Na inflow when voltage-gated fast Na channels open
- Resting membrane at -90mV
- Fibers are brought to threshold by action potential, voltage-gated fast Na channels open.
- Na inflows, producing rapid depolarization
- Within seconds Na channels inactivate and Na inflow decreases
2) Plateau: due to Ca inflow when voltage-gated slow Ca channels open and K outflow when some K channels open
- Opening voltage-gated slows Ca channels
- Ca ions move from interstitial into cytosol, causing even more Ca to pour out of sarcoplasmic reticulum into the cytosol through additional Ca channels
- This causes contraction
- Just before plateau begins, some K channels open, allowing Potassium to leave
- Depolarization is sustained during plateau because Ca inflow balance K outflow
- Membrane potential is at 0mV
3) Repolarization: due to closure of Ca channels and K outflow when additional voltage-gated K channels open
- Recovery of resting membrane potential
- Additional K channel open, outflow of K restores the negative resting membrane (-90mV)
- Ca channels are closing in sarcolemma and sarcoplasmic reticulum which also contributes to repolarization
What does an electrocardiogram record?
Records actions potentials produced by all the heart muscle fibers during each heartbeat
- -Can Determine:–
- Conducting pathway is abnormal
- Heart is enlarged
- Certain regions of heart is damaged
- Cause of chest pain