Midterm 1 Practice Exam Flashcards

1
Q

Bright daylight can influence:

a. Amount of melatonin secreted in humans
b. Phase of onset of melatonin secreted in humans
c. Phase of onset of activity in hamsters
d. All of the above

A

d.

All of the above

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

If free running hamsters in constant lighting conditions are given a light pulse during the middle of the subjective day, this will:

a. Phase advance the activity rhythm
b. Phase delay the activity rhythm
c. Have little or no effect on the activity rhythm
d. Cause the activity rhythm to be disrupted for 24 hours

A

c.

Have little or no effect on the activity rhythm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q
  1. Evidence from hamsters suggests that the activity-rest circadian rhythm can be entrained to any period within:
    a. 10-50 hours
    b. 18-26 hours
    c. 23-25 hours
    e. 16-36 hours
    f. Any period is entrainable, if the light is bright enough.
A

b.

18-26 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Biological rhythms observed in constant environmental conditions are said to be __________(4).

If an appropriate ___________(5) is given, the rhythm is said to become ___________ (6) to environmental conditions.

A

Biological rhythms observed in constant environmental conditions are said to be *Free-running (4).

If an appropriate *Zeitgeber (5) is given, the rhythm is said to become *Entrained (6) to environmental conditions.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

cdsc

A

cdsCd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

cds

A

cdscds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

In an early experiment by de Mairan, a mimosa plant was placed in a dark cabinet and temperature was held approximately constant.
The plant continued to show a daily rhythm of leaf movements, with leaves open during the day and folded at night.
This result indicates most conclusively that:

a. the natural daily rhythms of light and temperature are not required for rhythmic leaf movements.
b. chlorophyll is not involved in the mechanism of leaf movements.
c. the plant must be capable of using some environmental cue other than light or temperature to regulate its leaf movements.
d. leaf movements do not have any adaptive value to the plant.

A

a.

The natural daily rhythms of light and temperature are not required for rhythmic leaf movements.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

An experiment by de Candolle showed that the rhythmic leaf movements of the mimosa plant continued in constant darkness with a period length that was not exactly 24h.
This type of observation helped to convince biologists that:

a. plants have less accurate biological clocks than animals
b. biological clocks cannot continue to express consistent oscillations in the absence of time cues from the environment
c. the leaf movements of mimosa are fundamentally different from those of most plants
d. some daily rhythms are driven by internal, self-sustained oscillators
e. none of the above

A

d.

Some daily rhythms are driven by internal, self-sustained oscillators.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

A common feature of circadian, circannual, circatidal, and circalunar rhythms is that all of them:

a. are related to the period of the earth’s rotation about its own axis
b. are related to geophysical rhythms that may have some importance to organisms
c. have period lengths that usually vary in some regular relationship to an organism’s body size
d. have period lengths that are always shorter than the corresponding geophysical rhythm
e. all the above

A

b.

Are related to geophysical rhythms that may have some importance to organisms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

As compared to homeostatic processes, biological rhythms seem to be much less dependent on:

a. internal negative feedback mechanisms
b. genetically transmitted information
c. coordination between many cells
d. timekeeping mechanisms
e. the nervous system

A

a.

Internal negative feedback mechanisms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

For a nocturnal animal that is freerunning under constant conditions, the beginning of the active phase (locomotor activity) corresponds approximately to:

a. beginning of subjective day
b. beginning of subjective night
c. alpha
d. rho
e. mid-point of subjective day

A

b.

beginning of subjective night

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The term “temperature compensation” is most clearly illustrated by the observation that:

a. organisms are unable to entrain to daily cycles of environmental temperature
b. organisms are able to entrain to daily cycles of environmental temperature
c. mean environmental temperature has little effect on taudd
d. the phase angle of entrainment is not affected by environmental temperature
e. none of the above

A

mean environmental temperature has little effect on taudd

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Differences between individuals of a species with respect to tau:

a. may result from genetic differences
b. may be a result of different photoperiod histories of the individuals
c. may be related to age
d. do not exist
e. “a” , “b”, and “c”

A

e.

“a” , “b”, and “c”

a. may result from genetic differences
b. may be a result of different photoperiod histories of the individuals
c. may be related to age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Rodents are most likely to become arrhythmic (non-rhythmic) when exposed to:

a. continuous darkness (DD)
b. continuous light (LL)
c. a 24h light/dark cycle
d. constant (unvarying) temperature

A

b.

continuous light (LL)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

If you wanted to estimate the limits of entrainment to light/dark cycles for a particular species, which of the following would provide helpful information:

a. the degree of temperature compensation of its circadian clock
b. the phase response curve and tau
c. the phase angle of entrainment to a 12L:12D cycle (12h light and 12h dark)
d. all the above
e. none of the above

A

b.

The phase response curve and tau

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

For people on a normal day-night schedule, cortisol levels peak in the______________ and are lowest in_________________.

a. Early afternoon; late evening
b. Early morning; early evening
c. Early evening; early morning
d. Middle of the night; late afternoon

A

b. Early morning; early evening

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

The last link in the pathway to the pineal gland comes from the:

a. Superior cervical ganglia
b. Suprachiasmatic nuclei
c. Retinohypothalamic tract
d. Contralateral pineal gland

A

a.

Superior cervical ganglia

18
Q

All of the following are involved with mammalian photoperiodism except the

a. Pineal gland
b. Suprachiasmatic nucleus (SCN)
c. GnRH neurons
d. Hippocampus

A

Hippocampus

19
Q

The Aschoff Rule states that

a. light intensity affects the period of a rhythm
b. all circadian rhythms cycle at about 24 h
c. change in ambient temperature does not affect the period of the rhythm
d. a circadian rhythm is responsible for photoperiod time measurement

A

a.

light intensity affects the period of a rhythm

20
Q

A phase response curve (PRC) best describes

a. the period (=tau) of the rhythm
b. a rhythm’s entrainment properties
c. a rhythm’s response to changing temperature
d. the duration of the activity bout

A

b.

a rhythm’s entrainment properties

21
Q

Which of the following exhibits clock properties in birds?

a. Suprachiasmatic nucleus
b. Pineal gland
c. The retina of the eye
d. both a and b
e. a, b, and c

A

b. Pineal gland

???

22
Q

In general, seasonal reproduction in various avian and mammalian species is usually regulated by one of the following factors, but not

a. photoperiod
b. food availability
c. a circannual rhythm
d. temperature

A

temperature

23
Q

The critical feature of pineal gland function that causes short-day-induced gonadal regression in rodents is:

a. the duration of the daily melatonin rhythm
b. the amplitude of the daily melatonin rhythm
c. the secretion of melatonin pulses after dusk and before dawn
d. heightened receptor sensitivity to melatonin about 12 hours after dawn

A

a.

the duration of the daily melatonin rhythm

24
Q

Biological clocks are involved in all of the following events, except

a. the sun-arc hypothesis
b. photoperiod time measurement
c. night orientation to star patterns
d. the hibernation cycle of the ground squirrel
e. the feeding cycles of voles

A

c.

night orientation to star patterns

25
Q

Infradian rhythms refer to those rhythms with a period

a. of 24 hours
b. that is less than 24 hours
c. that is more than 24 hours
d. of 1 year

A

c.

that is more than 24 hours

26
Q

What is the single most defining characteristic of a true biological rhythm?

a. that it can be entrained by environmental cues
b. that it is self sustaining
c. that it requires a zeitgeber
d. all true biological rhythms are circadian

A

b.

that it is self sustaining

27
Q

Which region of the mammalian brain is viewed as the master clock that organizes all circadian rhythms?

a. preoptic area of the hypothalamus
b. hippocampus
c. pineal gland
d. suprachiasmatic nucleus

A

d.

suprachiasmatic nucleus

28
Q

Which of the following list of biological rhythms is ordered from most frequent to least frequent?

a. ultradian, circannual, circadian, infradian
b. ultradian, infradian, circadian, circannual
c. infradian, circadian, ultradian, circannual
d. ultradian, circadian, infradian, circannual

A

d.

ultradian, circadian, infradian, circannual

29
Q

What is photoperiodism?

a. the ability of light to entrain circadian rhythms
b. the ability to use day length to time annual cycles
c. the stimulation of the pineal gland of birds by light reflecting through the skull
e. the ability of light to entrain ultradian rhythms

A

b.

the ability to use day length to time annual cycles

30
Q

List 5 characteristics of biological clocks (10 points)

A
  1. Inherited
  2. Temperature Independent
  3. Relatively Resistant to the Influence of Chemicals
  4. Entrainment is Limited to Specific Ranges.
  5. Independent from Behavioral Feedback
  6. Biological clocks are found at Every Level of Organization within an organism.
31
Q

Describe the 2 ways that biological clocks allow animals to adapt to temporal fluctuations.

(4 points)

A

??

Anticipation of an Organisms Environment.
By registering local time and events (such as high and low tide), biological clocks allow organisms to prepare for and anticipate their environment.

Predictive Homeostasis is a good example of this:
An organism can activate certain systems preempting the changes that will occur in the environment.
E.g. in humans, cortisol levels are raised before we wake up, increasing the metabolic rate so we have the energy necessary for the day ahead.

Example: clocks coordinate when males and females of the same species become fertile so that the period of maximum fertility coincides, thus establishing a breeding season.

32
Q

What is the relationship of the circadian system to the ovulatory cycle in rats and hamsters?

(4 points)

A

??
Female hamsters display a pattern of activity onset called “scalloping.”

Every 4th night, coincident with estrus, females show a spontaneous phase advance in their activity onset.

Hamsters are solitary creatures, and it is speculated that the earlier onset of locomotor activity during estrus increases the female’s odds of locating a
male.

Phase shifts of entrainment were accompanied by
proportionate shifts in estrous cycle.
If the light-dark cycle changed to 25h, then estrous cycle changed to 100h; if reduced to 20h, then estrous cycle switched to 80h).

33
Q

Briefly describe and evaluate the experimental evidence that the SCN is an important neural clock in mammals.

A

??

a. SCNx (destruction of SCN by lesion)
- —> arrhythmicity

b. electrical or chemical stimulation of SCN
- —>phase shifts

c. rhythm of neural firing activity and 2DG uptake in SCN in vivo
1. rhythm of neural firing persists after surgical
isolation of SCN from neural connections with brain
2. rhythm of neural firing persists in vitro
3. rhythm of 2DG (2-deoxyglucose) uptake indicates
rhythm in metabolic rate.

SCN transplant studies:
Transplanted SCN restores locomotor activity rhythm in SCN lesioned hamsters

Lesions of the SCN abolish
circadian rhythms

SCN maintains rhythms in vitro

34
Q

In the 2nd part of your answer, propose what you think is the most important next step to understand SCN function as a neural pacemaker.
Defend your choice and provide a brief experimental approach as to how you would address the problem.

Use one page only.
(10 points)

A

The most important next step to understand SCN function as a neural pacemaker, at least as it pertains to medical application for human patients, is understanding how SCN function changes as humans age and what can be done to slow down the geriatric sleep changes that cause older people to sleep fewer hours and experience excessive phase shifting.

To improve treatment options for patients, experimental studies that expose the SCN, and just the SCN, of rodents with different neuroprotective substances could be conducted.
In these studies, the rodents could receive one neuroprotective substance consistently until its death, perhaps starting at the half-point of the average lifetime of the species (to correspond with middle-aged human).
The study would evaluate differences in the SCN aging in the treated rodents versus the untreated controls.
The study would evaluate changes in tau and phase shifts from birth to death, and compare the different neuroprotectve factors to the controls. Whichever substamce was most effective in slowing down the aging process of the SCN could be tried in human trials.

35
Q

FROM NOTES:

Describe behavior thoroughly

A
  • By action
  • By consequence
  • Simple system approach
  • Generate hypotheses about mechanisms underlying relevant behaviors.
36
Q

FROM NOTES:

Tinbergen’s Questions About Causes of Behavior:
4 LEVELS OF ANALYSIS

A

– IMMEDIATE CAUSATION

– DEVELOPMENT

– EVOLUTION/NATURAL SELECTION

– ADAPTIVE FUNCTION

37
Q

FROM NOTES:

7 Advantages of Animal Models

A
  • Continuity of behavior from one species to another through evolution.
  • Simplest system with qualities of interest.
  • More economical to develop methods on animals that may be useful for people.
  • Ethical considerations; some manipulation are not permissible in humans.
  • Function of behavior often becomes clearer when viewed in a comparative manner.
  • Places human system in perspective.
  • Generalizations can be gained from animal models then tested in humans.
38
Q

FROM NOTES:

Disadvantages of Animal Models

A

• Enormous Species Differences.
*Behaviors may represent adaptations to very specific environments.

• Huge Behavioral Gap between Animals & Humans.

  • Language & Cultural Evolution.
  • To get the “cleanest” answers about simplest analyses, the less cognition, the better.

• Ethical Considerations.

39
Q

FROM NOTES:

STRONG INFERENCE.
4 Steps

A

1) Devise alternative/multiple hypotheses.
2) Design & execute experiment that will permit rejection of as many of the hypotheses as possible.
3) Retain surviving hypotheses.

4) Recycle.
*Science advances only by disproofs.
Common Misconception: that goal of scientific enterprise is to develop theories that cannot be disproved.
Wrong.
Marxist, Freudian, Darwinian theories cannot be disproved.

40
Q

FROM NOTES:

COMPARISON OF
BIOLOGICAL RHYTHMS

A

• Circadian,
Revolution of planet
– 24 h (22-26h)

• Circatidal,
Tides
– 12.4 h (11-14 h)

• Circalunar,
Phases of the moon.
– 29.5 days (26-32 days)

• Circannual,
Seasons of the year.
– 365.25 days (300-400 days)

41
Q

FROM NOTES:

Peripheral Targets of the SCN

A
  • Kidney
  • Liver
  • Thyroid
  • Bladder
  • Spleen
  • Adrenal
  • Pancreas
  • Adipose (fat) Tissue