Midterm 1 Cards

Question 1

DaunoXome

Answer 1

Preservative Free single use Doxorubicin for IV
indication: kaposis sarcoma
Dose: 40mg/m^2/ in 60 min, every 2 weeks
Storage: 2-8 C
Advantage: decreased cardiotoxicity

Question 2

Trastuzumab

Answer 2

Humanized Ab

Targets HER2

Question 3

Antioxidants

Answer 3

alpha-tocopherol

hydroxytoluene (BHT)

Question 4

Vitravene

Answer 4

21mer phosphorothioate ASO

for cytomegalovirus induced retinitis in AIDS pts

Question 5

Cerumenlytic agents

Answer 5

triethanolamine polypeptide oleate condensate

carbamide peroxide

Question 6

Muromonab

Answer 6

Murine Ab

Attacks CD3 of T cell for transplant

Question 7

stable in glaass of PVC

Answer 7

aldesleukin

Question 8

Lyophilized and can be stored at room temp

Answer 8

Alteplase

Question 9

Local Intranasal drugs

Answer 9

beclometasone
mometasone
mupirosin

Question 10

Wetting Agent and Cosolvent

Answer 10

Glycerin

Question 11

Ophthalmic Preservatives

Answer 11

benzalkonium Chloride
Chlorobutanol
Phenylmercuric Acetate (nitrate)
Thimerosal

Question 12

Ophthalmic Ointment Bases

Answer 12

White petrolatum

Water soluble base

Question 13

Humira (adalimumab)

Answer 13

Binds TNF alpha

Question 14

Doxil

Answer 14

Stealth Liposome Doxorubicin for IV
10 ml red liquid in glass, single use
indication: anthracycline antineoplastic for Kaposi’s Sarcoma
Dose: 20 mg/m^2 in 30 min, once every 3 weeks
Preparation: up to 90 mg in 250 ml D5W
Storage: Use within 24 hour after reconstiution. Store in 2-8 C
Advantage: 90% drug retention, 55h T1/2

Question 15

Ambisome

Answer 15

Lyophilized Amphoterocin B suspension for IV
indication: antifungal
Dose: Administer for 2 hours
Preparation: sterile water
Storage: 2-8 C at 24 h or 6 h at room temp

Question 16

Abcelet

Answer 16

Sterile pyrogen free Amphoterocin B suspension for IV
indication: antifungal
Dose: 2.5mg/kg/h for 2 hours
Preparation: d5w
Storage: 2-8 C at 48 h or 6 h at room temp
Advantage: decreased nephrotoxicity

Question 17

thickening agent

Answer 17

carbomer copolymer type A
Cetyl alcohol
Methylcellulose
Hydrocymethylcellulose
Polyvinyl alcohol

Question 18

Liposome Charge Imparters

Answer 18

stearylamine (positive)

dicetyl-phosphate (negative)

Question 19

Rituximab

Answer 19

Binds CD20 on B-cell lymphoma

Causes CDC and ADCC

Question 20

Surfactant

Answer 20

Polysorbate 80
Cetyl alcohol
glyceryl monostearate
polyoxyl 40 stearate

Question 21

Stable in plastic syringe

Answer 21

somatropin and erythropoietin

Question 22

Ophthalmic Preservatives effective against p. aeruginosa

Answer 22

Benzalkonium Chloride and Polymyxin B

Benzalkonium Chloride and disodium EDTA

Question 23

systemic intranasal drugs

Answer 23

sumatriptan
salmon calcitonin
nicotine

Question 24

Sensitive to light

Answer 24

Dornase-alpha