Midterm 1

Question 1

AIDS requirements by def

Answer 1

Seropositivity (usually w ELISA test), <200 CD4 cell count per mm^3 blood, and one aids related illness

Question 2

Early immune failure diseases

Answer 2

Candida, shingles, hairy leukoplakia, TB (or something similar)

Question 3

Fungal infections

Answer 3

PCP and systemic mycosis

Question 4

Protozoan infections

Answer 4

Gastroenteritis and toxoplasma

Question 5

Bacterial

Answer 5

Mycobacterium

Question 6

Viral infections

Answer 6

Hepatitis, cytomegalovirus, herpes, JC virus

Question 7

Gag gene

Answer 7

Coat proteins

Question 8

Pol gene

Answer 8

RT, integrase (viral DNA), protease (proteins)

Question 9

Env gene

Answer 9

Viral envelope

Gp120 protein (binds to CD4)
Gp41 protein (fusion)

Question 10

CD4 vs. macrophage (CD4)

Answer 10

Has CXCR4
Can be lytic (dies)
Can be latent or active infected

Question 11

CD4 vs macrophage (macrophage)

Answer 11

CCR5 co receptor

Latent or active infection

Question 12

MHC-I

Answer 12

All cells, shows antigens, killer cells bind to it

Question 13

MHC-II

Answer 13

Extra cellular pathogen receptor, antigen presenting cell (Macros and B’s)

PAMP binds to PRR

Question 14

Recombination diversity

Answer 14

Mix and match antibody variable section, one will work

Question 15

Mutation in gp120 envelope

Answer 15

Good for HIV

Question 16

Berlin man

Answer 16

CCR5 missing so he cured

Question 17

Koch postulates

Answer 17

Has disease, isolate disease, introduce to healthy person, healthy person gets same disease