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Pharmacokinetics > Midterm 1 > Flashcards

Midterm 1 Flashcards

1
Q

What is Biopharmaceutics?

A

Physical and chemical properties of a drug in a dose form and the pharmacologic response after administration

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2
Q

What factors determine Biopharmaceutics?

A
  1. Chemical nature
  2. Physical state
  3. Dosage form
  4. Excipients
  5. pharmaceutical process
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3
Q

Pharmacokinetics is?

A

Study of ADME and the intensity and time of therapy and adverse effects

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4
Q

Bioavailability is?

A

rate and extent that a drug is absorbed into the body or site of action

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5
Q

Clinical pharmacokinetics is?

A

application in pharmacokinetics to individually optimize dosing based on PT disease states

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6
Q

Pharmacodynamics is?

A

Relationship btw drug concentration at site of actinon and the response to the body

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7
Q

Factors affecting absorption of drugs

A
  1. Age
  2. Blood Flow
  3. pH
  4. food
  5. drugs
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8
Q

Factors that increase rate of gastric emptying

A
  1. larger starting volume
  2. Solutions or suspensions empty faster
  3. Metoclopromide
  4. Aggressiveness increases
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9
Q

Factors that decrease rate of gastric emptying

A
  1. Anticholinergics
  2. Narcotic analgesics
  3. Ethanol
  4. Lying on LEFT side of body
  5. increase viscosity of the fluid
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10
Q

Factors affecting Dissolution rate

A
  1. Solubility
  2. Solvation
  3. Crystalline
  4. Particle size
  5. Complexation
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11
Q

Factors affecting Metabolism

A
  1. Age
  2. genetics
  3. disease state
  4. Drug drug interactions
  5. Food
  6. species
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12
Q

Factors affecting variability in drug response

A
  1. Genetics
  2. weight
  3. ethnicity
  4. diet
  5. gender
  6. compliance
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13
Q

Total body water (TBW)

A

60% of weight

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14
Q

Intracellular fluid (ICF)

A

40% of weight

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15
Q

Extracellular fluid (ECF)

A

20% of weight

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16
Q

Plasma fluid

A

4% of weight

17
Q

Total Blood volume (TBV)

A

7% of weight

18
Q

GFR is determine by

A
  1. Creatinine clearance
  2. PAH (filtered and secreted by kidney)
  3. Inulin (filtered but not secreted by kidney) 120mL/min is normal

Pharmacokinetics (1 decks)

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