Midterm 1 Flashcards
Three components of behaviour
- Input system (sensory)
- Integrator (CNS)
- Output/effector (muscles)
Cytokines
Chemical signals produced by immune system; hormones interact with them
Pigeon crop sac
Determine prolactin dose by injecting it to pigeon crop sac and measuring epithelial cell height
Rabbit test
Determine presence of hCG by injecting urine into rabbit. Present if forms corpora lutea
Intracrine
Intracellular
Autocrine
Self regulation
Paracrine
Influence nearby cells
Endocrine
Release into blood, affect distant cells
Ectocrine
Release into the environment, affect other animals
Endocrine glands
Ductless, have rich blood supply
Exocrine gland
Have ducts into which their products are released
E.g. Salivary, sweat, mammary glands
Exocytosis
Water-soluble hormones stored in vesicles, and when signalled to secrete, they fuse with the cell membrane and get released into extracellular space
Carrier protein
Carries lipid-soluble hormone through bloodstream
TRH
Thyrotropin releasing, hypothalamic, stimulates prolactin
GHRH
Growth hormone releasing, hypothalamic, release growth hormone
GnRH
Gonadotropin releasing, hypothalamic, stimulate FSH & LH
MRH
Melanotropin releasing, hypothalamic
CRH
Corticotropin releasing, hypothalamic, stimulate ACTH in anterior pituitary -> release of cortisol(glucocorticoid) in adrenal gland
GHIH
Growth hormone inhibiting, hypothalamic
GnIH
Gonadotropin inhibiting, hypothalamic
Dopamine
Hypothalamic, inhibit prolactin and melanotropin
Glycoproteins
Class of proteins that have carbohydrate groups attached; in anterior pituitary
Gonadotropins
Luteinizing hormone & follicle stimulating hormone
Steroidgenesis and maturation of gonads
Growth hormone
Anterior pituitary, stimulate release of somatomedin, cause bone growth
Prolactin
Anterior pituitary, stimulated by TRH or prolactin releasing factor such as oxytocin
Oxytocin
Posterior pituitary, milk letdown, uterine contraction
Vasopressin
Posterior pituitary, water balance, blood pressure
Calcitonin
Thyroid gland, reduces blood calcium level, oppose PTH
PTH
Parathyroid hormone, increase blood calcium level, oppose calcitonin
Insulin
Pancreatic peptide, beta, reduce blood glucose level by storing glucose as glycerin, oppose glucagon
Glucagon
Pancreatic, alpha, increase blood glucose level by breaking down glycogen in liver, oppose insulin
Somatostatin
Pancreatic, delta, inhibit insulin and glucagon
Steroid hormone
Formed from cholesterol, fat-soluble
TSH
Thyroid stimulating, anterior pituitary, stimulate thyroid gland to produce T4 –> T3, which regulates metabolism
Thyroid hormones
T4, T3, derived from tyrosine, metabolism
Adrenal medullary monoamine hormones
Tyrosine -> DA -> norepinephrine -> epinephrine
Pineal gland monoamine hormone
Tryptophan -> 5HT -> Melatonin (night), serotonin (day)
Anterior pituitary origin
Rathke’s pouch, outgrowth of roof of mouth
Adrenal medulla of adrenal gland
Release 3 monoamine hormones, DA, NE, epinephrine
Two compartmentalizations function of gonads
- Steroidgenesis, production of hormone
2. Gametogenesis, production of gametes
Semi-niferous tubules
Produces sperms in testes
Sertoli cells
Where sperms are embedded, provide nutrients
Leydig interstitial cells
Hormone producing cells in testes, in between tubules
Follicle
Contains egg in ovary
Corpora lutea
Structure that develops fro follicles after egg is released
Thecal cells
Secrete estrogens, have receptors for LH and can produce androgen from cholesterol in response to LH
Granulosa cells
Surround oocytes(immature egg), convert androgen to estrogen in response to FSH, and produce progesterone in response to LH
SRY
Encodes testis determination factor, which causes medulla of germinal ridge to develop into a testis
Dual anlagen
Presence of both accessory sex organs at the beginning
Müllerian duct
No hormone, then develop into Fallopian tubes, cervix, uterus
Wolffian duct
In presence of testosterone and MIH, develop into seminal vesicles and vas deferens
MIH
Mullerian inhibitory hormone, makes Müllerian duct regress
DHT
5-a dihydrotestosterone, converted from testosterone by enzyme 5a-reductase, necessary for development of penis
CAH
Congenital adrenal hyperplasia, adrenal glands produce too much androgen as opposed to cortisol, masculinization of genitals in females
CAIS
Complete androgen insensitivity syndrome, androgen receptors don’t function, XY males have female genitalia but with testes, raised as girls but sterile
5a- reductase deficiency
XY males born with ambiguous genitalia, raised as girls, but become men at puberty