Midterm 1

Question 1

C5a

Answer 1

Neutrophil Chemotaxis

Question 2

C5b, C6,C7,8,9

Answer 2

Cell lysis by membrane attaching unit

Question 3

C1 esterase deficiency

Answer 3

Angioedema

Question 4

C3 deficiency

Answer 4

Sepsis due to staph. aureus

Question 5

C5b, C6, C7, C8 deficiency

Answer 5

Increase infection susceptibility with gonococci, and meningiococci

Question 6

Class I MHC

Answer 6

On surface of Nucleated somatic cells

Binds to CD8 cells (tumor, virus, allografts)

Question 7

Class II MHC

Answer 7

On surface of APCs in immune response

Binds to CD4 to recognize antigens

Question 8

HLA-B27

Answer 8

Ankylosing Spondylitis

Question 9

HLA-DR3

Answer 9

SLE

Question 10

HLA DR4

Answer 10

Rheumatoid Arthiritis

Question 11

Type I Hypersensitivity

Answer 11

Immediate Rxn (anaphylaxis) IgE
Allergen->IgE->mast cells &basophils release
Ex: Local response for allergy; Pollen, dust, etc (second response more potent)
Tx: antihistamine, epinephrine, cortisone

Question 12

Type II hypersensitivity

Answer 12

Cytotoxic IgG or IgM
Ig attaches to Ag in Fab region->cell lysis
Ex: ABO blood transfusion, rheumatic fever, etc

Question 13

Type III hypersensitivity

Answer 13

Immune Complex IgG or IgM
Ag reacts with AB -> C5a release neutrophils->lysozyme causes tissue damage
Ex: serum sickness, auto immune

Question 14

Type IV hypersensitivity

Answer 14

Delayed hypersensitivity Tcells and Macrophages
Ex: Tuberculosis test, contact dermatitis
Tcell recognize Ag->CD4 and macrophage release cytosine & CD8-> lasts for days

Question 15

alpha Interferon

Answer 15

produced by Leukocytes for Hep B and Hep C

Question 16

Beta Interferon

Answer 16

Produced by fibroblasts for Viruses

Question 17

Gamma interferon

Answer 17

Produced by T cells for granulomatous disease

Question 18

Carcinoembryonic Ag (CEA)

Answer 18

Found in fetal gut, reappears in adult life

Question 19

Alpha Fetoprotein (AFP)

Answer 19

Fetal liver Ag, reappears in hepatic carcinoma

Question 20

RA

Answer 20

AB against IgG = Type III hypersensitivity

Question 21

Rheumatic Fever

Answer 21

AB against M protein of Streptococci cross rxn w/ heart muscle sarcolemma

Question 22

SLE

Answer 22

ABs against DNA

HLA-DR3

Question 23

Reiters Sx

Answer 23

Predisposition to infection

HLA-B27 Ag

Question 24

Myasthenia Gravis

Answer 24

AB against ACh receptors on NMJ

Question 25

Hemolytic Disease

Answer 25

ABs against RBCs->cell lysis

Question 26

Pernicious Anemia

Answer 26

ABs against parietal cells-> decrease B12

Question 27

Graves Disease

Answer 27

ABs to TSH receptors->increase TSH

Question 28

Hashimotos

Answer 28

ABs against thyroglobulin (inflammation of thyroid)

Question 29

Thymic Dysplasia

Answer 29

Decrease thymus and parathyroid glands= decrease T cells

Question 30

Chronic Mucocutaneous Candidiasis

Answer 30

Fungal infection= decreased t cells

Question 31

Brutons Aggamglobulinemia

Answer 31

X linked recessive of b cells= decreased Ig

Question 32

Selective Immunoglobulin deficiency

Answer 32

Decrease IgA= increase sinus infection, URTI, etc

Question 33

Severe COmbined Immunodificeincy disease (SCID)

Answer 33

Recurrent infections, x linked or autosomal

Question 34

WIskott-Aldrich Syndrome

Answer 34

Recurrent infection, bleeding

Question 35

Ataxia Telangiectasia

Answer 35

Recurrent infection, dilated blood vessels

Question 36

Cheddick higashi syndrome

Answer 36

lysosome and neutrophil failure

Question 37

Chronic granulomatous disease

Answer 37

Decrease NADPH enzyme=decrease phagocytosis

Question 38

AIDs

Answer 38

Carninii-Most common cause of death

Opportunistic infections-lymphoma