Midterm 1 Flashcards
Define pharmacology
The study of drugs
Define medical pharmacology
concerned with the use of chemical in the prevention, diagnosis, and treatment of disease
What is the definition of a drug
a chemical substance when administered to a biological organism produces a biological effect
What are the two pillars of pharmacology
pharmacokinetics and pharmacodynamics
Define pharmacokinetics
The effect of the body on the drug (absorption, metabolism, excretion and elimination) OR
The movement of drugs in the body
Define pharmacodynamics
The effect of the drug on the body (mechanism of action, therapeutic and toxic effects) OR the body’s biological response to the drug
What are the 4 ways drugs can be classified
effect, chemical origin (precursor), receptor, chemical structure
What is are examples of drugs classified by their effect?
Blood thinners and anti-inflammatories
What are the limitations of classifying drugs by their effect?
Does not acknowledge their side effects or drug interactions. Drugs can have similar effects but act on different receptors
What is the limitation of classifying drugs by their precursors
There is no information on their actual effect
What is are examples of drugs classified by their precursors?
Opiates are derived from the opium poppy whereas opioids are made in a lab but they work on the same receptor
What is the benefit of using receptor classification for drugs?
Can be applied for almost all drugs and looks at receptor occupancy (stimulates of inhibition)
What are the two types of adrenoreceptors? Where are they found
alpha and beta
Alpha 1 and 2: blood vessels
Beta 1: heart
Beta 2: lungs
What is the importance of receptors?
They determine the quantitative relations between dose or concentration of drug and pharmacologic effect, responsible for selectivity, mediate agonist and antagonist
What are some types of receptors
ion channel, G protein coupled, kinase kinked, intracellular, enzymes, voltage gated ion channels
