MIDTERM 03 - Dispensing Process Flashcards
2 examples of medications that interact with each other (PN)
Phosphodiesterase type 5 inhibitor (PDE5) and Nitrates
3 examples of nitrates (NII)
Nitroglycerin, ISMN, ISDN
Refers to situations where one drug affects the pharmacokinetics and pharmacodynamics of another drug when both are administered together
Drug-drug interaction
2 types of drug-drug interaction (PP)
Pharmacokinetic, Pharmacodynamic
Affects the absorption, distribution, metabolism, and excretion of drugs (Types of drug-drug interactions)
Pharmacokinetic interactions
Meaning of ADME (Pharmacokinetic interactions)
Absorption, Distribution, Metabolism, Excretion
Occurs when two drugs have the following interactions: potentiation, antagonism, synergism, and addition (Types of drug-drug interactions)
Pharmacodynamic interactions
Meaning of PASA (Pharmacodynamic interactions)
Potentiation, Antagonism, Synergism, Addition
The combined effect of two drugs is equal to the sum of their individual effects (1+1=2) (Pharmacodynamic interactions)
Addition interaction
One drug reduces or counteracts the effect of another drug; mostly used for toxicity/poisoning interactions (1+1=0) (Pharmacodynamic interactions)
Antagonistic interaction
The combined effect of two drugs is greater than the sum of their individual effects (1+1=>2) (Pharmacodynamic interactions)
Synergism interaction
One drug enhances the effect of another drug that has little or no effect on its own (1+0=2) (Pharmacodynamic interactions)
Potentiation interaction
Interaction of benzodiazepines and 1st generation antihistamines can lead to __________ (Example of addition reaction)
Increased sedation
Example of benzodiazepine
Diazepam
Example of 1st generation antihistamine
Diphenhydramine
Interaction of angiotensin II receptor blocker subtype 1 and calcium channel blockers can lead to __________ (Example of addition reaction)
Greater blood pressure lowering
Example of angiotensin II receptor blocker subtype 1
Losartan
Example of calcium channel blocker
Amlodipine
Interaction of ibuprofen and naproxen can lead to __________ (Example of addition reaction)
Greater anti-inflammatory effect