Mid Module Questions Practice Flashcards

1
Q

What is a partition coefficient?

A

Ability of drug to distribute into immiscible systems.

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2
Q

What are the challenges of drug absorption?

A

Drug needs to dissolved in aqueous media.

Drug needs to cross phospholipid bilayer and pass through non aqueous layer of PB- hence needs to be hydrophilic and to an extent hydrophobic.

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3
Q

How many solvents are used in partition coefficient studies???

A

Octanol
Propylene glycol-PGDP
Chloroform
Cyclohexane

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4
Q

What are the mechanisms of granulation?

A

Adhesion and cohesion forces in immobile films.

Interfacial forces in mobile liquid films.

Solid bridges.

Attractive forces between solid particles.

NTB (Nucleation, Transition, Ball Growth).

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5
Q

What’s Adsoption?

A

A surface effect.

Electrostatic interactions between compound and surface of the stationary phase.

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6
Q

What is Partition?

A

Applies to bonded phases.

Where the stationary phase is liquid coated onto a solid.

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7
Q

What is ion exchange?

A

Solute ions in the mobile phase can exchange with similarly charged ions bound to the stationary phase.

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